{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:39Z","timestamp":1772165679299,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-025-11914-2","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T18:32:37Z","timestamp":1763404357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case report of pancreatic tuberculosis: arterial infusion of isoniazid as an adjunct to oral antituberculosis medications has demonstrated promising therapeutic efficacy"],"prefix":"10.1186","volume":"25","author":[{"given":"Yipan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sicheng","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"11914_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ijid.2022.12.005","volume":"128","author":"T Li","year":"2023","unstructured":"Li T, Yan X, Du X, Huang F, Wang N, Ni N, et al. Extrapulmonary tuberculosis in china: a National survey. Int J Infect Dis. 2023;128:69\u201377.","journal-title":"Int J Infect Dis"},{"key":"11914_CR2","unstructured":"World Health O. Global tuberculosis report 2024. Geneva: World Health Organization. 2024;2024."},{"issue":"11","key":"11914_CR3","first-page":"CD012163","volume":"11","author":"S Jullien","year":"2016","unstructured":"Jullien S, Jain S, Ryan H, Ahuja V. Six-month therapy for abdominal tuberculosis. Cochrane Database Syst Rev. 2016;11(11):CD012163.","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"11914_CR4","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s00535-018-1452-4","volume":"53","author":"A Endo","year":"2018","unstructured":"Endo A, Shiraishi A, Fushimi K, Murata K, Otomo Y. Impact of continuous regional arterial infusion in the treatment of acute necrotizing pancreatitis: analysis of a National administrative database. J Gastroenterol. 2018;53(9):1098\u2013106.","journal-title":"J Gastroenterol"},{"issue":"1","key":"11914_CR5","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1186\/s12885-024-12695-8","volume":"24","author":"C Huang","year":"2024","unstructured":"Huang C, Cheng CS, Shen Y, Chen H, Lin J, Hua Y, et al. Digital Subtraction angiography-guided pancreatic arterial infusion of GEMOX chemotherapy in advanced pancreatic adenocarcinoma: a phase II, open-label, randomized controlled trial comparing with intravenous chemotherapy. BMC Cancer. 2024;24(1):941.","journal-title":"BMC Cancer"},{"key":"11914_CR6","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1016\/j.tube.2019.04.012","volume":"116S","author":"ER Erwin","year":"2019","unstructured":"Erwin ER, Addison AP, John SF, Olaleye OA, Rosell RC. Pharmacokinetics of isoniazid: the good, the bad, and the alternatives. Tuberculosis (Edinb). 2019;116S:S66\u201370.","journal-title":"Tuberculosis (Edinb)"},{"issue":"1","key":"11914_CR7","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0041-3879(90)90064-F","volume":"71","author":"KF Knowles","year":"1990","unstructured":"Knowles KF, Saltman D, Robson HG, Lalonde R. Tuberculous pancreatitis. Tubercle. 1990;71(1):65\u20138.","journal-title":"Tubercle"},{"issue":"2","key":"11914_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.gtc.2021.02.004","volume":"50","author":"H Eraksoy","year":"2021","unstructured":"Eraksoy H. Gastrointestinal and abdominal tuberculosis. Gastroenterol Clin North Am. 2021;50(2):341\u201360.","journal-title":"Gastroenterol Clin North Am"},{"issue":"9","key":"11914_CR9","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1111\/j.1572-0241.1999.01389.x","volume":"94","author":"CH Chen","year":"1999","unstructured":"Chen CH, Yang CC, Yeh YH, Yang JC, Chou DA. Pancreatic tuberculosis with obstructive jaundice\u2013a case report. Am J Gastroenterol. 1999;94(9):2534\u20136.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"11914_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.2214\/ajr.184.1.01840050","volume":"184","author":"AI De Backer","year":"2005","unstructured":"De Backer AI, Mortel\u00e9 KJ, Bomans P, De Keulenaer BL, Vanschoubroeck IJ, Kockx MM. Tuberculosis of the pancreas: MRI features. AJR Am J Roentgenol. 2005;184(1):50\u20134.","journal-title":"AJR Am J Roentgenol"},{"issue":"4","key":"11914_CR11","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/2050640620902353","volume":"8","author":"N Panic","year":"2020","unstructured":"Panic N, Maetzel H, Bulajic M, Radovanovic M, L\u00f6hr JM. Pancreatic tuberculosis: A systematic review of symptoms, diagnosis and treatment. United Eur Gastroenterol J. 2020;8(4):396\u2013402.","journal-title":"United Eur Gastroenterol J"},{"issue":"7","key":"11914_CR12","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3748\/wjg.v18.i7.720","volume":"18","author":"S Meesiri","year":"2012","unstructured":"Meesiri S. Pancreatic tuberculosis with acquired immunodeficiency syndrome: a case report and systematic review. World J Gastroenterol. 2012;18(7):720\u20136.","journal-title":"World J Gastroenterol"},{"issue":"2","key":"11914_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1111\/jgh.12410","volume":"29","author":"JB Kim","year":"2014","unstructured":"Kim JB, Lee SS, Kim SH, Byun JH, Park DH, Lee TY, et al. Peripancreatic tuberculous lymphadenopathy masquerading as pancreatic malignancy: a single-center experience. J Gastroenterol Hepatol. 2014;29(2):409\u201316.","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"11914_CR14","first-page":"395","volume":"27","author":"SS Rana","year":"2014","unstructured":"Rana SS, Sharma V, Sampath S, Sharma R, Mittal BR, Bhasin DK. Vascular invasion does not discriminate between pancreatic tuberculosis and pancreatic malignancy: a case series. Ann Gastroenterol. 2014;27(4):395\u20138.","journal-title":"Ann Gastroenterol"},{"key":"11914_CR15","doi-asserted-by":"publisher","first-page":"860740","DOI":"10.3389\/fonc.2022.860740","volume":"12","author":"F Hu","year":"2022","unstructured":"Hu F, Hu Y, Wang D, Ma X, Yue Y, Tang W, et al. Cystic neoplasms of the pancreas: differential diagnosis and radiology correlation. Front Oncol. 2022;12:860740.","journal-title":"Front Oncol"},{"issue":"52","key":"11914_CR16","doi-asserted-by":"publisher","first-page":"e13858","DOI":"10.1097\/MD.0000000000013858","volume":"97","author":"PJ Sun","year":"2018","unstructured":"Sun PJ, Lin Y, Cui XJ. Isolated pancreatic tuberculosis with elevated CA 19\u2009\u2013\u20099 levels masquerading as a malignancy: A rare case report and literature review. Med (Baltim). 2018;97(52):e13858.","journal-title":"Med (Baltim)"},{"issue":"8","key":"11914_CR17","doi-asserted-by":"publisher","first-page":"300060523118913","DOI":"10.1177\/03000605231189134","volume":"51","author":"Y Gu","year":"2023","unstructured":"Gu Y, Xiao M, Wan Z, Li Q. Isolated pancreatic tuberculosis masquerading as malignancy in an immunocompetent host: a case report and review of the literature. J Int Med Res. 2023;51(8):3000605231189134.","journal-title":"J Int Med Res"},{"issue":"2","key":"11914_CR18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1111\/jgh.13174","volume":"31","author":"V Sharma","year":"2016","unstructured":"Sharma V, Rana SS, Kumar A, Bhasin DK. Pancreatic tuberculosis. J Gastroenterol Hepatol. 2016;31(2):310\u20138.","journal-title":"J Gastroenterol Hepatol"},{"issue":"5","key":"11914_CR19","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.gie.2011.12.032","volume":"75","author":"R Puri","year":"2012","unstructured":"Puri R, Mangla R, Eloubeidi M, Vilmann P, Thandassery R, Sud R. Diagnostic yield of EUS-guided FNA and cytology in suspected tubercular intra-abdominal lymphadenopathy. Gastrointest Endosc. 2012;75(5):1005\u201310.","journal-title":"Gastrointest Endosc"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-11914-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-025-11914-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-025-11914-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T07:02:28Z","timestamp":1763449348000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-025-11914-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["11914"],"URL":"https:\/\/doi.org\/10.1186\/s12879-025-11914-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4503910\/v1","asserted-by":"object"}]},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"30 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The publication of this case report was approved by the Medical Ethics Committee of Zhongnan Hospital of Wuhan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The progressively worsening upper abdominal distension and pain had significantly disrupted my daily life. After seeking medical attention, my attending physicians conducted a thorough analysis and diagnosis of my condition. I was quite surprised to learn that the pancreatic mass was caused by a tuberculosis infection. However, after listening to the doctors\u2019 professional explanation, I agreed to undergo arterial infusion therapy. My abdominal pain was quickly relieved in a short period of time, which allowed me to return to normal work and life soon afterward. Following my discharge, I continued to take anti-tuberculosis medication regularly at home as prescribed. During this period, I did not experience any discomfort and felt no different from when I was in good health. I am truly grateful to the medical team for their dedication and care.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patient perspective"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1597"}}