{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:14:40Z","timestamp":1772165680666,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early-onset prosthetic valve endocarditis (EO-PVE) is linked to poor in-hospital outcomes. Staphylococcus spp. poses a significant concern due to its higher mortality rates compared to other major infectious agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Provide a more detailed, comprehensive evaluation of the clinical characteristics and in-hospital mortality predictors related to staphylococcal EO-PVE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational, retrospective, single-center study was conducted at a tertiary hospital in Brazil from 1997 to 2019, spanning a 22-year period. A total of 105 consecutive cases of left-heart staphylococcal EO-PVE were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a predominance of coagulase-negative staphylococci prosthetic valve endocarditis (CoNS PVE) over Staphylococcus aureus prosthetic valve endocarditis (SAPVE) (76% and 24%, respectively). Prosthetic valve replacement for EO-PVE treatment was performed in 73% of cases. In-hospital mortality was 49%, with SAPVE associated with a higher in-hospital mortality than CoNS PVE (80% versus 43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In-hospital mortality predictors identified by univariate analysis included older age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), aortic prosthetic endocarditis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), peri-annular abscess (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), SAPVE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), NYHA functional class III\/IV (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), previous combined myocardial revascularization with valve replacement surgery (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), left ventricular dysfunction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), leukocytosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02), and higher C-reactive protein levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). In a multivariate analysis, SAPVE was identified as an independent risk factor for in-hospital mortality (odds ratio [OR] 10.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), whereas prosthetic valve replacement was associated with improved in-hospital survival (OR 0.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Staphylococcal EO-PVE is associated with increased in-hospital mortality, particularly in SAPVE cases. In this study, all non-operated SAPVE patients died primarily due to fulminant septic shock. Prosthetic valve replacement was significantly linked to in-hospital survival, and only 5.7% of the study population survived without cardiac surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-025-11999-9","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T02:24:45Z","timestamp":1766111085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Staphylococcal early-onset prosthetic valve endocarditis: a condition bound for surgery"],"prefix":"10.1186","volume":"26","author":[{"given":"Antonio de","family":"Santis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Cukierkorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Tarasoutchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roney Orismar","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tshimbalanga","family":"Merite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena R.","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Manuel","family":"A. 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Ethical approval was obtained from the Ethics Committee for the Analysis of Research Projects of the Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo (Comiss\u00e3o de \u00c9tica para An\u00e1lise de Projetos de Pesquisa do HCFMUSP) (Approval No. 6,151,073; CAAE 70,354,523.10000.0068). As this was a retrospective study using data from medical records, the Ethics Committee for the Analysis of Research Projects of the Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo waived the requirement for informed consent. The approved study period was from July 1, 2023, to November 30, 2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"122"}}