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However, it remains a major public-health concern in Colombia, where healthcare authorities have suggested that the main issue is the incorrect implementation of the clinical practice guidelines (CPG). This study aimed to understand why this preventable disease cannot be prevented in Choc\u00f3 and Caldas, two regions of Colombia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A qualitative online study, using a multi-method approach following interpretative and ethnographic online research principles, was conducted in two regions of Colombia (Choc\u00f3 and Caldas) during the COVID-19 pandemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Besides the difficulties of, and barriers to, implementing the CPG identified in other studies in Colombia and elsewhere, three main gaps are highlighted as results of the study. (1) The CPG is usually implemented in a fragmented system. It specifies timelines and trajectories to be met in dynamic, inter-connected and under-resourced systems. (2) The CPG\u2019s implementation requires measures and activities that go before and beyond prenatal care and involve more than pregnant women and healthcare workers. (3) The CPG are for preventing the specific disease, but the implementation is enacted in relation to other diseases (HIV, COVID-19, hepatitis B, hypertension, diabetes) and their protocols and clinical guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The implementation of the CPG is important but insufficient for CS prevention. The CPG does not operate in isolation. In addition to the knowledge of the CPG and the provision of the necessary resources, it is crucial to consider the activities and processes before and after prenatal care to address the fragmentation of the healthcare system and healthcare services provision. Moreover, it is essential to coordinate the activities and practices for other diseases (HIV, COVID-19, hypertension, hepatitis B, diabetes) with those of the CPG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-026-12652-9","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:34:08Z","timestamp":1769700848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Difficulties with clinical practice guidelines for congenital syphilis prevention in Colombia: a qualitative study"],"prefix":"10.1186","volume":"26","author":[{"given":"Ana","family":"Estrada-Jaramillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Farrimond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"12652_CR1","unstructured":"Ministerio de Salud y Protecci\u00f3n Social y Fondo de Poblaci\u00f3n de las Naciones Unidas. 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Available from: http:\/\/iris.paho.org\/xmlui\/bitstream\/handle\/123456789\/34306\/PAHOCHA17009-eng.pdf?sequence=1&isAllowed=y"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-12652-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-12652-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-12652-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:21:25Z","timestamp":1781630485000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12879-026-12652-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["12652"],"URL":"https:\/\/doi.org\/10.1186\/s12879-026-12652-9","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"assertion":[{"value":"12 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The University of Exeter Ethical Committee approved and monitored this study (Approval number: 202021-018). Written informed consent was obtained from healthcare workers and administrators participants. Oral informed consent from the participants who were pregnant women and recent mothers, their partners and the traditional midwives was obtained by following a script and recorded as voice or text messages. Oral informed-consent was sought due to the mistrust that some ethnic groups have regarding signing documents and the large number of scams occurring in Colombia via WhatsApp and mobile phones.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable, because no individual data is included.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"435"}}