{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:54:57Z","timestamp":1781636097988,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paragonimiasis is a parasitic disease characterized by diverse clinical manifestations, among which pulmonary involvement is the most frequently observed. However, there are no documented cases of paragonimiasis presenting as a mediastinal mass. We report a case of paragonimiasis associated with such a presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A large mediastinal mass was identified in a 13-year-old child. Due to the limited efficacy of antibiotics and indeterminate diagnosis, thoracoscopic surgery was performed. Histopathological findings were consistent with paragonimiasis. The patient responded well to praziquantel treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This report reveals a novel, mediastinal presentation of paragonimiasis, a neglected disease, which posed a significant diagnostic dilemma due to its atypical features. Diagnostic thoracoscopy was essential for obtaining a definitive diagnosis, highlighting the importance of considering invasive diagnostic procedures when conventional approaches fail. The present case serves to remind clinicians to include paragonimiasis in the differential diagnosis of a mediastinal mass with chronic cough, especially in endemic areas or with a relevant dietary history.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-026-12893-8","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:04:15Z","timestamp":1771232655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediastinal mass as an unusual presentation of paragonimiasis in a child: a case report and review of diagnostic challenges"],"prefix":"10.1186","volume":"26","author":[{"given":"Shuchun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"issue":"2","key":"12893_CR1","doi-asserted-by":"publisher","first-page":"e0009120","DOI":"10.1371\/journal.pntd.0009120","volume":"15","author":"M Rabone","year":"2021","unstructured":"Rabone M, Wiethase J, Clark PF, Rollinson D, Cumberlidge N, Emery AM. Endemicity of Paragonimus and paragonimiasis in Sub-Saharan africa: A systematic review and mapping reveals stability of transmission in endemic foci for a multi-host parasite system. PLoS Negl Trop Dis. 2021;15(2):e0009120. https:\/\/doi.org\/10.1371\/journal.pntd.0009120.","journal-title":"PLoS Negl Trop Dis"},{"issue":"10","key":"12893_CR2","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.3201\/eid2810.220927","volume":"28","author":"JCN Diaz","year":"2022","unstructured":"Diaz JCN, Anselmi M, Calvopi\u00f1a M, Vera MEP, Cabrera YLC, Perlaza JJ, Cabezas LAO, Gaspar COR, Buonfrate D. Pulmonary paragonimiasis in native Community, Esmeraldas Province, Ecuador, 2022. Emerg Infect Dis. 2022;28(10):2114\u20136. https:\/\/doi.org\/10.3201\/eid2810.220927.","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"12893_CR3","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1038\/s41598-021-81694-7","volume":"11","author":"M Qian","year":"2021","unstructured":"Qian M, Li F, Zhang Y, Qiao Z, Shi Y, Shen J. A retrospective clinical analysis of pediatric paragonimiasis in a Chinese children\u2019s hospital from 2011 to 2019. Sci Rep. 2021;11(1):2005. https:\/\/doi.org\/10.1038\/s41598-021-81694-7.","journal-title":"Sci Rep"},{"issue":"5","key":"12893_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1212\/wnl.0000000000004896","volume":"90","author":"M Wang","year":"2018","unstructured":"Wang M, Ju Y, Liu X, Lv L, Wang Z, Jiang S. Hemorrhagic intraspinal paragonimiasis. 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This study was approved by the Medical Ethics Committee of Jinan Children\u2019s Hospital(QLET-IRB\/P-2024007).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian for the publication of this case report, including images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"620"}}