{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:04:07Z","timestamp":1792800247619,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding"},{"name":"Chinese National Key Technology R&D Program, Ministry of Science and Technology","id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"CAMS Innovation Fund for Medical Sciences"},{"name":"The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","id":[{"id":"https:\/\/ror.org\/02drdmm93","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-026-13359-7","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T15:48:11Z","timestamp":1776786491000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rhino-orbito-cerebral Rhizopus delemar infection in a patient with anti-melanoma differentiation-associated-5-positive dermatomyositis diagnosed by metagenomic next-generation sequencing: a case report"],"prefix":"10.1186","volume":"26","author":[{"given":"Zhao","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"1","key":"13359_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s12879-023-08192-1","volume":"23","author":"S XIE","year":"2023","unstructured":"XIE S, LAI Z, XIA H, et al. A case report of brainstem hemorrhage due to Rhizopus delemar-induced encephalitis diagnosed by metagenomic next-generation sequencing (mNGS) [J]. BMC Infect Dis. 2023;23(1):235.","journal-title":"BMC Infect Dis"},{"issue":"2","key":"13359_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.idc.2021.03.009","volume":"35","author":"JM STEINBRINK","year":"2021","unstructured":"STEINBRINK JM, MICELI MH. Mucormycosis [J]. Infect Dis Clin North Am. 2021;35(2):435\u201352.","journal-title":"Infect Dis Clin North Am"},{"issue":"1","key":"13359_CR3","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cmi.2018.07.011","volume":"25","author":"W JEONG","year":"2019","unstructured":"JEONG W, KEIGHLEY C, WOLFE R, et al. The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports [J]. Clin Microbiol Infect. 2019;25(1):26\u201334.","journal-title":"Clin Microbiol Infect"},{"key":"13359_CR4","doi-asserted-by":"crossref","unstructured":"Lu X. Peng Q, Wang G. Anti-MDA5 antibody-positive dermatomyositis: pathogenesis and clinical progress [J]. Nat Rev Rheumatol. 2023.","DOI":"10.1038\/s41584-023-01054-9"},{"key":"13359_CR5","doi-asserted-by":"publisher","first-page":"747116","DOI":"10.3389\/fimmu.2021.747116","volume":"12","author":"J QIAN","year":"2021","unstructured":"QIAN J, XU H. COVID-19 Disease and Dermatomyositis: A Mini-Review [J]. Front Immunol. 2021;12:747116.","journal-title":"Front Immunol"},{"issue":"1","key":"13359_CR6","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10753-023-01903-5","volume":"47","author":"Y CHEN","year":"2024","unstructured":"CHEN Y, JIANG Q, QING F, et al. MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis\/Killing Functions [J]. Inflammation. 2024;47(1):191\u2013208.","journal-title":"Inflammation"},{"issue":"8","key":"13359_CR7","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1007\/s10875-020-00847-x","volume":"40","author":"S OKADA","year":"2020","unstructured":"OKADA S, ASANO T, MORIYA K, et al. Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy [J]. J Clin Immunol. 2020;40(8):1065\u201381.","journal-title":"J Clin Immunol"},{"issue":"9","key":"13359_CR8","first-page":"e44768","volume":"15","author":"S EL HAKKOUNI A, HARRAR","year":"2023","unstructured":"EL HAKKOUNI A, HARRAR S, HACHIMI A, et al. Rhino-Orbito-Cerebral Mucormycosis: A Challenging Case [J]. Cureus. 2023;15(9):e44768.","journal-title":"Cureus"},{"issue":"1","key":"13359_CR9","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13244-021-01109-z","volume":"12","author":"V PAI","year":"2021","unstructured":"PAI V, SANSI R, KHARCHE R, et al. Rhino-orbito-cerebral Mucormycosis. Pict Rev [J] Insights Imaging. 2021;12(1):167.","journal-title":"Pict Rev [J] Insights Imaging"},{"key":"13359_CR10","doi-asserted-by":"crossref","unstructured":"REID G, LYNCH J P 3RD, FISHBEIN M C. CLARK N M. Mucormycosis [J]. Semin Respir Crit Care Med. 2020;41(1):99\u2013114.","DOI":"10.1055\/s-0039-3401992"},{"issue":"1","key":"13359_CR11","doi-asserted-by":"publisher","first-page":"5243","DOI":"10.1038\/s41598-018-23611-z","volume":"8","author":"M LIU","year":"2018","unstructured":"LIU M, BRUNI G O, TAYLOR C M, et al. Comparative genome-wide analysis of extracellular small RNAs from the mucormycosis pathogen Rhizopus delemar [J]. Sci Rep. 2018;8(1):5243.","journal-title":"Sci Rep"},{"key":"13359_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fcimb.2020.00088","volume":"10","author":"XING X W","year":"2020","unstructured":"XING X W, ZHANG J T, MA Y B, et al. Metagenomic Next-Generation Sequencing for Diagnosis of Infectious Encephalitis and Meningitis: A Large, Prospective Case Series of 213 Patients [J]. Front Cell Infect Microbiol. 2020;10:88.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"13359_CR13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/mmy\/myx017","volume":"56","author":"CORZO-LEON D E","year":"2018","unstructured":"CORZO-LEON D E, CHORA-HERNANDEZ L D, RODRIGUEZ-ZULUETA A P, WALSH T J. Diabetes mellitus as the major risk factor for mucormycosis in Mexico: Epidemiology, diagnosis, and outcomes of reported cases [J]. Med Mycol. 2018;56(1):29\u201343.","journal-title":"Med Mycol"},{"key":"13359_CR14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ejim.2022.03.008","volume":"100","author":"Y CAG","year":"2022","unstructured":"CAG Y, ERDEM H, GUNDUZ M, et al. Survival in rhino-orbito-cerebral mucormycosis: An international, multicenter ID-IRI study [J]. Eur J Intern Med. 2022;100:56\u201361.","journal-title":"Eur J Intern Med"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-13359-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13359-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13359-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:46:43Z","timestamp":1780530403000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12879-026-13359-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["13359"],"URL":"https:\/\/doi.org\/10.1186\/s12879-026-13359-7","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"16 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient lacked decision-making capacity due to critical illness and CNS involvement. Written informed consent was obtained from her legally authorized representative in accordance with her prior directives and ethical guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"1079"}}