{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:35:39Z","timestamp":1787510139820,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chagas disease is a global public health issue, life-threatening parasitic disease, affecting mostly underserved communities in Latin America. Yet, 10% of infected individuals are diagnosed, and 1% receive etiological treatment. Priority actions for disease elimination by 2030 are streamlining diagnostic methods and evaluating and developing point-of-care diagnostics. We convened 44 researchers, test developers, and health authorities, to provide scientific advice and reach consensus on\n                    <jats:italic>(i)<\/jats:italic>\n                    a harmonized protocol for evaluation of rapid diagnostic tests;\n                    <jats:italic>(ii)<\/jats:italic>\n                    preferred molecular diagnostics characteristics (scope, performance, operational features, pricing, and evaluation standards); and\n                    <jats:italic>(iii)<\/jats:italic>\n                    economic impact evidence needed to have a transformational impact in primary healthcare. We considered global and national perspectives with discordant evidence from multiple disciplines. Our outcomes provide a reference on practical applications and recommendations to promote test development and evaluation. Finally, we debate about the appropriate approach moving forward to meet the diagnostic gap, and propose how investments could be stimulated.\n                  <\/jats:p>","DOI":"10.1186\/s12879-026-13565-3","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:39:06Z","timestamp":1781696346000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Advancing diagnostics for Chagas disease: key product characteristics and harmonized evaluation strategies - an expert meeting report"],"prefix":"10.1186","volume":"26","author":[{"given":"Laura C.","family":"Bohorquez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro G.","family":"Schijman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Coto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marchiol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Jesus","family":"Pinazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"issue":"4","key":"13565_CR1","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","volume":"13","author":"BY Lee","year":"2013","unstructured":"Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: A computational simulation model. Lancet Infect Dis. 2013;13(4):342\u20138.","journal-title":"Lancet Infect Dis"},{"key":"13565_CR2","doi-asserted-by":"crossref","unstructured":"Costa Chaves G, Abi-Saab Arrieche M, Rode J, Mechali D, Ouverney Reis P, Alves RV, Stobbaerts E. Gir\u00f3n Aguilar N RI. Estimaci\u00f3n de la demanda de medicamentos antichag\u00e1sicos: Una contribuci\u00f3n para el acceso en Am\u00e9rica Latina (Estimating demand for anti-Chagas drugs: a contribution for access in Latin America) | DNDi. 2017.","DOI":"10.26633\/RPSP.2017.45"},{"key":"13565_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.socscimed.2017.01.002","volume":"175","author":"ZM Cucunub\u00e1","year":"2017","unstructured":"Cucunub\u00e1 ZM, Manne-Goehler JM, D\u00edaz D, Nouvellet P, Bernal O, Marchiol A, et al. How universal is coverage and access to diagnosis and treatment for Chagas disease in Colombia? A health systems analysis. Soc Sci Med. 2017;175:187\u201398.","journal-title":"Soc Sci Med"},{"issue":"10","key":"13565_CR4","doi-asserted-by":"publisher","first-page":"724","DOI":"10.7326\/0003-4819-144-10-200605160-00006","volume":"144","author":"R Viotti","year":"2006","unstructured":"Viotti R, Vigliano C, Lococo B, Bertocchi G, Petti M, Alvarez MG, et al. Long-term cardiac outcomes of treating chronic chagas disease with benznidazole versus no treatment: A nonrandomized trial. Ann Intern Med. 2006;144(10):724\u201334.","journal-title":"Ann Intern Med"},{"issue":"11","key":"13565_CR5","doi-asserted-by":"publisher","first-page":"e3312","DOI":"10.1371\/journal.pntd.0003312","volume":"8","author":"DL Fabbro","year":"2014","unstructured":"Fabbro DL, Danesi E, Olivera V, Codeb\u00f3 MO, Denner S, Heredia C, et al. Trypanocide treatment of women infected with Trypanosoma cruzi and its effect on preventing congenital Chagas. PLoS Negl Trop Dis. 2014;8(11):e3312.","journal-title":"PLoS Negl Trop Dis"},{"key":"13565_CR6","unstructured":"Gobierno de Chile. Norma general t\u00e9cnica control y prevenci\u00f3n nacional de la enfermedad de Chagas. Departamento de Enfermedad de Enfermedades Transmisibles Divisi\u00f3n de Prevenci\u00f3n y Control de Enfermedades Subsecretar\u00eda de Salud P\u00fablica. 2014."},{"key":"13565_CR7","unstructured":"Ministerio de Salud de Argentina. Algoritmos de diagn\u00f3stico y tratamiento para el control de las infecciones perinatales por VIH, s\u00edfilis, hepatitis B y Chagas Iniciativa ETMI-PLUS. 2024."},{"key":"13565_CR8","unstructured":"Conselleria de sanitat - Comunitat Valenciana. Enfermedad De Chagas Importada Protocolo De Actuaci\u00f3n En La Comunitat Valenciana. 2009."},{"issue":"4","key":"13565_CR9","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3201\/1504.080438","volume":"15","author":"Y Jackson","year":"2009","unstructured":"Jackson Y, Myers C, Diana A, Marti HP, Wolff H, Chappuis F, et al. Congenital transmission of Chagas disease in Latin American immigrants in Switzerland. Emerg Infect Dis. 2009;15(4):601\u20133.","journal-title":"Emerg Infect Dis"},{"key":"13565_CR10","unstructured":"Public Health Agency of Catalonia. Ministry of Health. Protocol for screening, diagnosis and treatment of Chagas disease in pregnant Latin American women, their newborns and other children. 2018."},{"key":"13565_CR11","unstructured":"WHO. Ending the neglect to attain the Sustainable Development Goals: A road map for neglected tropical diseases 2021\u20132030 [Internet]. 2021. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240010352."},{"key":"13565_CR12","doi-asserted-by":"publisher","unstructured":"PAHO. Uso de pruebas de diagn\u00f3stico r\u00e1pido para la enfermedad de Chagas en las Am\u00e9ricas [Internet], Washington DC. 2024. Available from: https:\/\/doi.org\/10.37774\/9789275329382.","DOI":"10.37774\/9789275329382"},{"key":"13565_CR13","doi-asserted-by":"crossref","unstructured":"Rivero R, Albizu C, Rodriguez M, Esteva M, Oliveto A, Santini S et al. Comparative evaluation of four rapid diagnostic tests that detect human Trypanosoma cruzi-specific antibodies to support territorial case diagnosis of Chagas Disease in Buenos Aires, Argentina. Manuscr Submitt Publ. 2023.","DOI":"10.1371\/journal.pntd.0011997"},{"key":"13565_CR14","doi-asserted-by":"crossref","unstructured":"L\u00f3pez R, Garc\u00eda A, Aruni Chura JJ, Balboa V, Rodr\u00edguez A, Erkosar B, et al. Comparative evaluation of lateral flow assays to diagnose chronic Trypanosoma cruzi infection in Bolivia. Manuscr Submitt Publ. 2023.","DOI":"10.1371\/journal.pntd.0012016"},{"key":"13565_CR15","doi-asserted-by":"crossref","unstructured":"Marchiol A, Florez C, Caicedo A, Segura M, Bautista J, Ayala M, et al. Laboratory evaluation of 11 rapid diagnostic tests for serological diagnosis of Chagas disease in Colombia. Accept Manuscr Publ. 2023.","DOI":"10.1371\/journal.pntd.0011547"},{"key":"13565_CR16","doi-asserted-by":"publisher","first-page":"1031455","DOI":"10.3389\/fmed.2023.1031455","volume":"10","author":"JAD Iturra","year":"2023","unstructured":"Iturra JAD, Leony LM, Medeiros FAC, de Souza Filho JA, Siriano Lda, Tavares R. A multicenter comparative study of the performance of four rapid immunochromatographic tests for the detection of anti-Trypanosoma cruzi antibodies in Brazil. Front Med. 2023;10:1031455.","journal-title":"Front Med"},{"key":"13565_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.12688\/gatesopenres.12817.1","volume":"2","author":"R Young","year":"2018","unstructured":"Young R, Bekele T, Gunn A, Chapman N, Chowdhary V, Corrigan K, et al. Developing new health technologies for neglected diseases: a pipeline portfolio review and cost model. Gates open Res. 2018;2:23.","journal-title":"Gates open Res"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13565-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-13565-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13565-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:20:55Z","timestamp":1781742055000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12879-026-13565-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":17,"journal-issue":{"issue":"S1","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["13565"],"URL":"https:\/\/doi.org\/10.1186\/s12879-026-13565-3","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"assertion":[{"value":"17 June 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"1160"}}