{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:14:40Z","timestamp":1788315280552,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":98,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Anhui Provincial Center for Disease Control and Prevention"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-026-13652-5","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T01:54:44Z","timestamp":1779846884000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic hepatitis C infection status among HCV-Ab positive patients above 50 years old in Anhui Province from 2004 to 2022"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1166-3961","authenticated-orcid":false,"given":"Liping","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7050-3612","authenticated-orcid":false,"given":"Zeyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0724-9033","authenticated-orcid":false,"given":"Yangguang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0546-5439","authenticated-orcid":false,"given":"Meng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1443-1594","authenticated-orcid":false,"given":"Yongsheng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9112-0384","authenticated-orcid":false,"given":"Ziwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-9974","authenticated-orcid":false,"given":"Seying","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-8082","authenticated-orcid":false,"given":"Yinguang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"issue":"1","key":"13652_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1055\/s-2007-1007260","volume":"15","author":"CJ Mansell","year":"1995","unstructured":"Mansell CJ, Locarnini SA. Epidemiology of hepatitis C in the East. Semin Liver Dis. 1995;15(1):15\u201332. https:\/\/doi.org\/10.1055\/s-2007-1007260.","journal-title":"Semin Liver Dis"},{"key":"13652_CR2","unstructured":"WHO, Hepatitis, C [EB\/OL]. (2024-04-26). [2025-01-16]. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-c"},{"key":"13652_CR3","unstructured":"Wu HB, Zhou ZX, Huang YX. Analysis of epidemiological characteristics of viral hepatitis C in China, 2004\u20132011[J]. Mod Prev Med. 2015;42:1173\u20135."},{"key":"13652_CR4","unstructured":"WHO. Global health sector strategy on viral hepatitis 2016\u20132021. Towards ending viral hepatitis [EB\/OL]. (2016-05-17). [2025-01-26]. https:\/\/www.who.int\/publications\/i\/item\/WHO-HIV-2016.06"},{"issue":"12","key":"13652_CR5","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","volume":"3","author":"T Akinyemiju","year":"2017","unstructured":"Akinyemiju T, Abera S, Ahmed M, et al. The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015 [J]. JAMA Oncol. 2017;3(12):1683\u201391.","journal-title":"JAMA Oncol"},{"issue":"12","key":"13652_CR6","first-page":"e75902","volume":"16","author":"R Chowdhury","year":"2024","unstructured":"Chowdhury R, Rashid W, Singh T, et al. Outcomes of Direct-Acting Antivirals Versus Interferon-Based Therapy in Chronic Hepatitis C Infection [J]. Cureus. 2024;16(12):e75902.","journal-title":"Cureus"},{"issue":"10","key":"13652_CR7","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.jsps.2022.07.005","volume":"30","author":"SJ Alarfaj","year":"2022","unstructured":"Alarfaj SJ, Alzahrani A, Alotaibi A, et al. The effectiveness and safety of direct-acting antivirals for hepatitis C virus treatment: A single-center experience in Saudi Arabia [J]. Saudi Pharm J. 2022;30(10):1448\u201353.","journal-title":"Saudi Pharm J"},{"key":"13652_CR8","first-page":"29","volume":"41","author":"Chinese Society of Hepatology, Chinese Society of Infectious Diseases","year":"2023","unstructured":"Chinese Society of Hepatology, Chinese Society of Infectious Diseases. Guidelines for the Prevention and Treatment of hepatitis C (2022 Edition) [J]. Chin J Infect Dis. 2023;41:29\u201346.","journal-title":"Chin J Infect Dis"},{"key":"13652_CR9","unstructured":"Li N, Liu L, Ji XY, et al. Infection status of hepatitis C cases previously reported in Henan Province from 2004 to 2021[J]. Chin J AIDS STD. 2024:683\u20137."},{"issue":"5","key":"13652_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1111\/jvh.13062","volume":"26","author":"R Xu","year":"2019","unstructured":"Xu R, Yu Y, Leitch EC, M, et al. HCV genotype 6 prevalence, spontaneous clearance and diversity among elderly members of the Li ethnic minority in Baisha County, China [J]. J Viral Hepat. 2019;26(5):529\u201340.","journal-title":"J Viral Hepat"},{"key":"13652_CR11","first-page":"1367","volume":"42","author":"D Wang","year":"2015","unstructured":"Wang D, Wu JB, Shi G. Q.Analysis on the changes of proportion and epidemiological characteristics of hepatitis C from 2004 to 2012 in Anhui province[J]. Mod Prev Med. 2015;42:1367\u20139.","journal-title":"Mod Prev Med"},{"key":"13652_CR12","unstructured":"Pan HY, He JC, Tao R, et al. Investigation on the characteristics of 261 cases of hepatitis C and the awareness of prevention and treatment in Jiulongpo District of Chongqing from 2006 to 2023[J]. J Prev Med Inf. 2024:1\u20136."},{"key":"13652_CR13","unstructured":"Chinese medical association hepatology branch. Infectious Diseases Branch of the Chinese Medical Association. Guideline for the prevention and treatment of hepatitis C (2022 version)[J]. Chin J Infect Dis. 2023;41: 29\u201346."},{"key":"13652_CR14","first-page":"1420","volume":"28","author":"ZW Wang","year":"2024","unstructured":"Wang ZW, Li Y, Huang ZJ, et al. Awareness and testing willingness of Hepatitis C among people aged 50 and above in Anhui Province[J]. Chin J Dis Control Prev. 2024;28:1420\u20135.","journal-title":"Chin J Dis Control Prev"},{"key":"13652_CR15","unstructured":"Guan SH, Rao ZY, Yi LC, et al. Analysis of antiviral treatment status and influencing factors of previous hepatitis C patients in Linchuan District, Fuzhou City from 2004 to 2022[J]. Appl Prev Med. 2024;30:490\u20134."},{"key":"13652_CR16","doi-asserted-by":"crossref","unstructured":"Ebermeyer T, Cognasse F, Berthelot P, et al. Platelet innate immune receptors and TLRs: a double-edged sword [J]. Int J Mol Sci. 2021;22(15).","DOI":"10.3390\/ijms22157894"},{"key":"13652_CR17","unstructured":"Wang Y, Han J, Yang MR. Twenty-four month follow-up for patients with chronic hepatitis C after sustained virological response to different DAAs treatment regimen[J]. J Pract Hepatol. 2024;27:32\u20135."},{"key":"13652_CR18","unstructured":"Cao Y. Analysis of the efficacy of DAAs in treating special populations with HCV infection and related influencing factors [D]. 2024."},{"issue":"1","key":"13652_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/hep.26639","volume":"59","author":"J Grebely","year":"2014","unstructured":"Grebely J, Page K, Sacks-Davis R, et al. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection [J]. Hepatology. 2014;59(1):109\u201320.","journal-title":"Hepatology"},{"issue":"6","key":"13652_CR20","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1002\/hep.20463","volume":"40","author":"V Di Martino","year":"2004","unstructured":"Di Martino V, Lebray P, Myers RP, et al. Progression of liver fibrosis in women infected with hepatitis C: long-term benefit of estrogen exposure [J]. Hepatology. 2004;40(6):1426\u201333.","journal-title":"Hepatology"},{"issue":"1","key":"13652_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/heapol\/16.1.41","volume":"16","author":"Z Wu","year":"2001","unstructured":"Wu Z, Rou K, Detels R. Prevalence of HIV infection among former commercial plasma donors in rural eastern China [J]. Health Policy Plan. 2001;16(1):41\u20136.","journal-title":"Health Policy Plan"},{"key":"13652_CR22","unstructured":"Li T, Ji GP, Yan XH. Status and gender difference of elderly people living with AIDS transmitted through paid blood donation in rural areas of North Anhui Province[J]. Med Society. 2023;36:66\u201371."},{"key":"13652_CR23","unstructured":"Wei WE. Analysis on HIV infector in Xinyang City[J]. Occup Health. 2008:880\u20131."},{"key":"13652_CR24","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.2147\/RMHP.S459173","volume":"17","author":"Z Xie","year":"2024","unstructured":"Xie Z, Duan Z. Evolving Challenges in the Implementation of China\u2019s Four Frees and One Care Policy for HIV\/AIDS [J]. Risk Manag Healthc Policy. 2024;17:1315\u201321.","journal-title":"Risk Manag Healthc Policy"},{"issue":"8","key":"13652_CR25","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S2468-1253(21)00218-1","volume":"6","author":"U Samarasekera","year":"2021","unstructured":"Samarasekera U. Urgent action needed to eliminate viral hepatitis by 2030. Lancet Gastroenterol Hepatol. 2021;6(8):611.","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"13652_CR26","unstructured":"HIV\/AIDS Treatment and Care. World Health Organization (WHO)."},{"key":"13652_CR27","doi-asserted-by":"crossref","unstructured":"Al-Naamani KM, Omar H, Al Busafi SA, et al. Real-world experience, effectiveness, and safety of direct-acting antivirals for the treatment of hepatitis C in Oman: a cross-sectional, multicenter study [J]. J Clin Med. 2024;13(23).","DOI":"10.3390\/jcm13237411"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-13652-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13652-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-13652-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:26:03Z","timestamp":1788312363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12879-026-13652-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["13652"],"URL":"https:\/\/doi.org\/10.1186\/s12879-026-13652-5","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"18 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Anhui Medical University (Ethical approval number: 83230107). Written informed consent was obtained from all individual participants included in the study.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This manuscript does not contain any individual person\u2019s data in any form.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1593"}}