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The relationship between the laboratory parameters (Neutrophil-lymphocyte ratio (NLR) and Platelete-lymphocyte ratio (PLR), fibrinogen, D-dimer, procalcitonin, ferritin, and C-reactive protein, blood urea nitrogen (BUN), creatinine (Crea)), and COVID-19 mortality was examined by comparison with the survival group. Logistic regression analysis was performed to investigate the independent factors affecting mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1519 COVID-19 patients were analyzed. Mortality was observed in 799 patients (52.6%), and survival was observed in799 patients (52.6%). Neutrophil-lymphocyte ratio (NLR) and Platelete-lymphocyte ratio (PLR) averages were found to be higher and more significant in the mortality group compared to the survival group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The levels of fibrinogen, D-dimer, procalcitonin, ferritin, and C-reactive protein (CRP), which are acute-phase reactants, were found to be higher and statistically significant in the mortality group than in the survival group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and blood urea nitrogen (BUN), creatinine (Crea), aspartate aminotransferase (AST), and C-reactive protein (CRP) were found to be independent factors affecting mortality in patients with COVID-19 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SII and CAR cannot be used as independent predictors of mortality in COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-026-13730-8","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:23:44Z","timestamp":1780669424000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of CAR and SII values in determining mortality in COVID-19 patients: a retrospective observational study"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8470-8529","authenticated-orcid":false,"given":"Sedat","family":"\u00d6zbay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-504X","authenticated-orcid":false,"given":"Orhan","family":"\u00d6zsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-7442","authenticated-orcid":false,"given":"Tansu","family":"Gen\u00e7er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-1601","authenticated-orcid":false,"given":"Mustafa","family":"Korkut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3823-2929","authenticated-orcid":false,"given":"Cihan","family":"Bedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-4721","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Kavalc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-2946","authenticated-orcid":false,"given":"Cemil","family":"Kavalc\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"issue":"10225","key":"13730_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0140-6736(20)30260-9","volume":"395","author":"JT Wu","year":"2020","unstructured":"Wu JT, Leung K, Leung GM. 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