{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:56:38Z","timestamp":1791219398110,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To systematically analyze the epidemiological characteristics and genotype distribution of low-risk human papillomavirus (LR-HPV) infection in Jingzhou, China, and to provide evidence for optimizing regional strategies for the prevention and control of HPV-related diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cross-sectional study included 24,027 women who underwent cervical cancer screening and concurrent HPV genotyping at Jingzhou Hospital Affiliated to Yangtze University between October 2022 and September 2025. A flow-through hybridization technique was employed to detect 27 HPV genotypes (17 high-risk and 10 low-risk types). The prevalence and genotype distribution of LR-HPV were analyzed, with further stratification by age and season.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall HPV infection rate among the 24,027 participants was 25.94% (6,233\/24,027), with a LR-HPV infection rate of 10.06% (2,416\/24,027). The predominant LR-HPV genotypes were HPV81 (3.33%), HPV61 (2.55%), and HPV44 (1.63%), which differed from the detection rates of the traditionally common LR-HPV types HPV6 (0.82%) and HPV11 (0.32%). The age stratification analysis revealed a U-shaped bimodal distribution of LR-HPV prevalence, with peaks in women aged\u2009\u2264\u200920 years (16.02%) and over 60 years (19.15%) (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Single genotype infections predominated. Seasonally, LR-HPV prevalence was highest in autumn (10.78%) and lowest in summer (9.50%), but the differences were not statistically significant (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LR-HPV infection among women in Jingzhou is characterized by a unique regional genotype distribution dominated by HPV81, 61, and 44, with a bimodal age-specific prevalence pattern involving women aged\u2009\u2264\u200920 years and &gt;\u200960 years. This genotype profile differs from those reported in other regions of China, underscoring the importance of incorporating local epidemiological data into the formulation of regional HPV-related disease prevention and screening strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-026-13885-4","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:45:03Z","timestamp":1782391503000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiological characteristics and genotype distribution of low-risk human papillomavirus infection among women in Jingzhou, Central China: a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"given":"Shangjie","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-9366","authenticated-orcid":false,"given":"Ping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"6","key":"13885_CR1","first-page":"394","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 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