{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:37:01Z","timestamp":1792787821812,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":88,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Institut Pasteur","award":["E- 024519"],"award-info":[{"award-number":["E- 024519"]}],"id":[{"id":"https:\/\/ror.org\/0495fxg12","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Infect Dis"],"DOI":"10.1186\/s12879-026-14031-w","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:14:46Z","timestamp":1784286886000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abdominal symptoms of invasive meningococcal disease are associated with the induction of plasminogen activator inhibitor-1 in omental adipocytes"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0716-3174","authenticated-orcid":false,"given":"Muhamed-Kheir","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Gros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Aouiti-Trabelsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala-Eddine","family":"Deghmane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"issue":"18","key":"14031_CR1","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1056\/NEJM200105033441807","volume":"344","author":"NE Rosenstein","year":"2001","unstructured":"Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM. Meningococcal disease. N Engl J Med. 2001;344(18):1378\u201388.","journal-title":"N Engl J Med"},{"issue":"Pt 9","key":"14031_CR2","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1099\/jmm.0.45529-0","volume":"53","author":"SP Yazdankhah","year":"2004","unstructured":"Yazdankhah SP, Caugant DA. Neisseria meningitidis: an overview of the carriage state. J Med Microbiol. 2004;53(Pt 9):821\u201332.","journal-title":"J Med Microbiol"},{"issue":"12","key":"14031_CR3","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S1473-3099(10)70251-6","volume":"10","author":"H Christensen","year":"2010","unstructured":"Christensen H, May M, Bowen L, Hickman M, Trotter CL. Meningococcal carriage by age: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10(12):853\u201361.","journal-title":"Lancet Infect Dis"},{"key":"14031_CR4","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s40121-021-00468-w","volume":"10","author":"C Weil-Olivier","year":"2021","unstructured":"Weil-Olivier C, Taha MK, Emery C, Bouee S, Beck E, Aris E, Loncle-Provot V, Nachbaur G, Pribil C. Healthcare Resource Consumption and Cost of Invasive Meningococcal Disease in France: A Study of the National Health Insurance Database. Infect Dis Ther. 2021;10:1607\u201323.","journal-title":"Infect Dis Ther"},{"issue":"1","key":"14031_CR5","doi-asserted-by":"publisher","first-page":"2021764","DOI":"10.1080\/21645515.2021.2021764","volume":"18","author":"C Weil-Olivier","year":"2022","unstructured":"Weil-Olivier C, Taha MK, Bouee S, Emery C, Loncle-Provot V, Nachbaur G, Beck E, Pribil C. Care pathways in invasive meningococcal disease: a retrospective analysis of the French national public health insurance database. Hum Vaccin Immunother. 2022;18(1):2021764.","journal-title":"Hum Vaccin Immunother"},{"issue":"6","key":"14031_CR6","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1080\/21645515.2020.1849518","volume":"17","author":"MK Taha","year":"2021","unstructured":"Taha MK, Weil-Olivier C, Bouee S, Emery C, Nachbaur G, Pribil C, Loncle-Provot V. Risk factors for invasive meningococcal disease: a retrospective analysis of the French national public health insurance database. Hum Vaccin Immunother. 2021;17(6):1858\u201366.","journal-title":"Hum Vaccin Immunother"},{"issue":"5","key":"14031_CR7","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.tim.2007.03.005","volume":"15","author":"MC Schneider","year":"2007","unstructured":"Schneider MC, Exley RM, Ram S, Sim RB, Tang CM. Interactions between Neisseria meningitidis and the complement system. Trends Microbiol. 2007;15(5):233\u201340.","journal-title":"Trends Microbiol"},{"issue":"1","key":"14031_CR8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/14760584.2019.1557520","volume":"18","author":"R Acevedo","year":"2019","unstructured":"Acevedo R, Bai X, Borrow R, Caugant DA, Carlos J, Ceyhan M, Christensen H, Climent Y, De Wals P, Dinleyici EC, et al. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations. Expert Rev Vaccines. 2019;18(1):15\u201330.","journal-title":"Expert Rev Vaccines"},{"issue":"5","key":"14031_CR9","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.jinf.2015.07.007","volume":"71","author":"J Lucidarme","year":"2015","unstructured":"Lucidarme J, Hill DM, Bratcher HB, Gray SJ, du Plessis M, Tsang RS, Vazquez JA, Taha MK, Ceyhan M, Efron AM, et al. Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage. J Infect. 2015;71(5):544\u201352.","journal-title":"J Infect"},{"issue":"8","key":"14031_CR10","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1093\/cid\/ciy257","volume":"67","author":"T Guiddir","year":"2018","unstructured":"Guiddir T, Gros M, Hong E, Terrade A, Denizon M, Deghmane AE, Taha MK. Unusual initial abdominal presentations of invasive meningococcal disease. Clin Infect Dis. 2018;67(8):1220\u20137.","journal-title":"Clin Infect Dis"},{"key":"14031_CR11","doi-asserted-by":"crossref","unstructured":"Campbell H, Parikh SR, Borrow R, Kaczmarski E, Ramsay ME, Ladhani SN. Presentation with gastrointestinal symptoms and high case fatality associated with group W meningococcal disease (MenW) in teenagers, England, July 2015 to January 2016. Euro Surveill. 2016;21(12).","DOI":"10.2807\/1560-7917.ES.2016.21.12.30175"},{"key":"14031_CR12","doi-asserted-by":"publisher","first-page":"e126","DOI":"10.1017\/S0950268821001035","volume":"149","author":"O S\u00e4ll","year":"2021","unstructured":"S\u00e4ll O, Stenmark B, Jacobsson S, Eriksson L, Thulin Hedberg S, Hertting O, Fredlund H, Sundqvist M, Molling P. Atypical presentation of Neisseria meningitidis serogroup W disease is associated with the introduction of the 2013 strain. Epidemiol Infect. 2021;149:e126.","journal-title":"Epidemiol Infect"},{"issue":"1","key":"14031_CR13","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.amjmed.2017.08.002","volume":"131","author":"H Cheddani","year":"2018","unstructured":"Cheddani H, Desgabriel AL, Coffin E, Taha MK, Verdet C, Bachmeyer C, Flejou JF, Amiot X. No Neck Pain: Meningococcemia. Am J Med. 2018;131(1):37\u201340.","journal-title":"Am J Med"},{"issue":"10","key":"14031_CR14","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.cgh.2009.05.026","volume":"7","author":"GF Longstreth","year":"2009","unstructured":"Longstreth GF, Yao JF. Epidemiology, clinical features, high-risk factors, and outcome of acute large bowel ischemia. Clin Gastroenterol Hepatol. 2009;7(10):1075\u201380. e1071-1072; quiz 1023.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"14031_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/flgastro-2019-101204","volume":"12","author":"A Hung","year":"2021","unstructured":"Hung A, Calderbank T, Samaan MA, Plumb AA, Webster G. Ischaemic colitis: practical challenges and evidence-based recommendations for management. Frontline Gastroenterol. 2021;12(1):44\u201352.","journal-title":"Frontline Gastroenterol"},{"issue":"1","key":"14031_CR16","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1128\/IAI.70.1.407-411.2002","volume":"70","author":"CM Tsai","year":"2002","unstructured":"Tsai CM, Kao G, Zhu P. Influence of the length of the lipooligosaccharide alpha chain on its sialylation in Neisseria meningitidis. Infect Immun. 2002;70(1):407\u201311.","journal-title":"Infect Immun"},{"issue":"8","key":"14031_CR17","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1086\/651505","volume":"201","author":"LH Harrison","year":"2010","unstructured":"Harrison LH, Shutt KA, Schmink SE, Marsh JW, Harcourt BH, Wang X, Whitney AM, Stephens DS, Cohn AA, Messonnier NE, et al. Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era\u2013United States, 2000\u20132005. J Infect Dis. 2010;201(8):1208\u201324.","journal-title":"J Infect Dis"},{"issue":"2","key":"14031_CR18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1128\/iai.16.2.471-475.1977","volume":"16","author":"RE Mandrell","year":"1977","unstructured":"Mandrell RE, Zollinger WD. Lipopolysaccharide serotyping of Neisseria meningitidis by hemagglutination inhibition. Infect Immun. 1977;16(2):471\u20135.","journal-title":"Infect Immun"},{"issue":"2","key":"14031_CR19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jinf.2017.10.015","volume":"76","author":"E Hong","year":"2018","unstructured":"Hong E, Barret AS, Terrade A, Denizon M, Antona D, Aouiti-Trabelsi M, Deghmane AE, Parent du Chatelet I, Levy-Bruhl D, Taha MK. Clonal replacement and expansion among invasive meningococcal isolates of serogroup W in France. J Infect. 2018;76(2):149\u201358.","journal-title":"J Infect"},{"key":"14031_CR20","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1186\/1471-2105-11-595","volume":"11","author":"KA Jolley","year":"2010","unstructured":"Jolley KA, Maiden MC. BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics. 2010;11:595.","journal-title":"BMC Bioinformatics"},{"issue":"Pt 11","key":"14031_CR21","doi-asserted-by":"publisher","first-page":"3013","DOI":"10.1099\/00221287-145-11-3013","volume":"145","author":"MP Jennings","year":"1999","unstructured":"Jennings MP, Srikhanta YN, Moxon ER, Kramer M, Poolman JT, Kuipers B, van der Ley P. The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis. Microbiology. 1999;145(Pt 11):3013\u201321.","journal-title":"Microbiology"},{"issue":"7","key":"14031_CR22","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1128\/iai.55.7.1652-1656.1987","volume":"55","author":"CM Tsai","year":"1987","unstructured":"Tsai CM, Mocca LF, Frasch CE. Immunotype epitopes of Neisseria meningitidis lipooligosaccharide types 1 through 8. Infect Immun. 1987;55(7):1652\u20136.","journal-title":"Infect Immun"},{"key":"14031_CR23","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1128\/jb.85.6.1274-1279.1963","volume":"85","author":"DS Kellogg Jr","year":"1963","unstructured":"Kellogg DS Jr., Peacock WL Jr., Deacon WE, Brown L, Pirkle DI. Neisseria gonorrhoeae. I. Virulence Genetically Linked to Clonal Variation. J Bacteriol. 1963;85:1274\u20139.","journal-title":"J Bacteriol"},{"issue":"1","key":"14031_CR24","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0003-2697(82)90673-X","volume":"119","author":"CM Tsai","year":"1982","unstructured":"Tsai CM, Frasch CE. A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels. Anal Biochem. 1982;119(1):115\u20139.","journal-title":"Anal Biochem"},{"issue":"4","key":"14031_CR25","doi-asserted-by":"publisher","first-page":"698","DOI":"10.3201\/eid2204.150653","volume":"22","author":"A Agnememel","year":"2016","unstructured":"Agnememel A, Hong E, Giorgini D, Nunez-Samudio V, Deghmane AE, Taha MK. Neisseria meningitidis Serogroup X in Sub-Saharan Africa. Emerg Infect Dis. 2016;22(4):698\u2013702.","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"14031_CR26","first-page":"177","volume":"26","author":"H Abdillahi","year":"1988","unstructured":"Abdillahi H, Poolman JT. Typing of group-B Neisseria meningitidis with monoclonal antibodies in the whole-cell ELISA. J Med Microbiol. 1988;26(3):177\u201380.","journal-title":"J Med Microbiol"},{"issue":"3","key":"14031_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0882-4010(92)90022-G","volume":"13","author":"DM Jones","year":"1992","unstructured":"Jones DM, Borrow R, Fox AJ, Gray S, Cartwright KA, Poolman JT. The lipooligosaccharide immunotype as a virulence determinant in Neisseria meningitidis. Microb Pathog. 1992;13(3):219\u201324.","journal-title":"Microb Pathog"},{"issue":"1","key":"14031_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1128\/jb.154.1.269-277.1983","volume":"154","author":"PJ Hitchcock","year":"1983","unstructured":"Hitchcock PJ, Brown TM. Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels. J Bacteriol. 1983;154(1):269\u201377.","journal-title":"J Bacteriol"},{"issue":"7","key":"14031_CR29","doi-asserted-by":"publisher","first-page":"e22210","DOI":"10.1371\/journal.pone.0022210","volume":"6","author":"M Szatanik","year":"2011","unstructured":"Szatanik M, Hong E, Ruckly C, Ledroit M, Giorgini D, Jopek K, Nicola MA, Deghmane AE, Taha MK. Experimental meningococcal sepsis in congenic transgenic mice expressing human transferrin. PLoS ONE. 2011;6(7):e22210.","journal-title":"PLoS ONE"},{"issue":"1","key":"14031_CR30","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1128\/MMBR.68.1.154-171.2004","volume":"68","author":"D Perkins-Balding","year":"2004","unstructured":"Perkins-Balding D, Ratliff-Griffin M, Stojiljkovic I. Iron transport systems in Neisseria meningitidis. Microbiol Mol Biol Rev. 2004;68(1):154\u201371.","journal-title":"Microbiol Mol Biol Rev"},{"key":"14031_CR31","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.steroids.2015.05.013","volume":"101","author":"M Levy","year":"2015","unstructured":"Levy M, Antunes A, Fiette L, Deghmane AE, Taha MK. Impact of corticosteroids on experimental meningococcal sepsis in mice. Steroids. 2015;101:96\u2013102.","journal-title":"Steroids"},{"issue":"9","key":"14031_CR32","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25(9):1105\u201311.","journal-title":"Bioinformatics"},{"issue":"3","key":"14031_CR33","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/nprot.2012.016","volume":"7","author":"C Trapnell","year":"2012","unstructured":"Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc. 2012;7(3):562\u201378.","journal-title":"Nat Protoc"},{"key":"14031_CR34","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/978-1-4939-3167-5_18","volume":"1374","author":"S Ghosh","year":"2016","unstructured":"Ghosh S, Chan CK. Analysis of RNA-Seq Data Using TopHat and Cufflinks. Methods Mol Biol. 2016;1374:339\u201361.","journal-title":"Methods Mol Biol"},{"issue":"4","key":"14031_CR35","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402\u20138.","journal-title":"Methods"},{"issue":"1","key":"14031_CR36","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1186\/s12879-024-09547-y","volume":"24","author":"S Taha","year":"2024","unstructured":"Taha S, Deghmane AE, Taha MK. Recent increase in atypical presentations of invasive meningococcal disease in France. BMC Infect Dis. 2024;24(1):640.","journal-title":"BMC Infect Dis"},{"issue":"10","key":"14031_CR37","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1086\/340501","volume":"185","author":"JM Braun","year":"2002","unstructured":"Braun JM, Blackwell CC, Poxton IR, El Ahmer O, Gordon AE, Madani OM, Weir DM, Giersen S, Beuth J. Proinflammatory responses to lipo-oligosaccharide of Neisseria meningitidis immunotype strains in relation to virulence and disease. J Infect Dis. 2002;185(10):1431\u20138.","journal-title":"J Infect Dis"},{"issue":"11","key":"14031_CR38","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1128\/IAI.00506-12","volume":"80","author":"CM John","year":"2012","unstructured":"John CM, Liu M, Phillips NJ, Yang Z, Funk CR, Zimmerman LI, Griffiss JM, Stein DC, Jarvis GA. Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals. Infect Immun. 2012;80(11):4014\u201326.","journal-title":"Infect Immun"},{"issue":"7","key":"14031_CR39","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1074\/jbc.M115.666214","volume":"291","author":"CM John","year":"2016","unstructured":"John CM, Phillips NJ, Din R, Liu M, Rosenqvist E, Hoiby EA, Stein DC, Jarvis GA. Lipooligosaccharide Structures of Invasive and Carrier Isolates of Neisseria meningitidis Are Correlated with Pathogenicity and Carriage. J Biol Chem. 2016;291(7):3224\u201338.","journal-title":"J Biol Chem"},{"issue":"2","key":"14031_CR40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1006\/cyto.2000.0803","volume":"13","author":"MR Mirlashari","year":"2001","unstructured":"Mirlashari MR, Hoiby EA, Holst J, Lyberg T. Outer membrane vesicles from Neisseria meningitidis: effects on cytokine production in human whole blood. Cytokine. 2001;13(2):91\u20137.","journal-title":"Cytokine"},{"issue":"5","key":"14031_CR41","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3109\/00365549309008547","volume":"25","author":"E Schlichting","year":"1993","unstructured":"Schlichting E, Lyberg T, Solberg O, Andersen BM. Endotoxin liberation from Neisseria meningitidis correlates to their ability to induce procoagulant and fibrinolytic factors in human monocytes. Scand J Infect Dis. 1993;25(5):585\u201394.","journal-title":"Scand J Infect Dis"},{"issue":"9178","key":"14031_CR42","first-page":"556","volume":"354","author":"PW Hermans","year":"1999","unstructured":"Hermans PW, Hibberd ML, Booy R, Daramola O, Hazelzet JA, de Groot R, Levin M. 4G\/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene and outcome of meningococcal disease. Meningococcal Res Group Lancet. 1999;354(9178):556\u201360.","journal-title":"Meningococcal Res Group Lancet"},{"issue":"Suppl 7","key":"14031_CR43","doi-asserted-by":"publisher","first-page":"S453","DOI":"10.1086\/431996","volume":"41","author":"PW Hermans","year":"2005","unstructured":"Hermans PW, Hazelzet JA. Plasminogen activator inhibitor type 1 gene polymorphism and sepsis. Clin Infect Dis. 2005;41(Suppl 7):S453\u2013458.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"14031_CR44","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0049-3848(90)90326-8","volume":"57","author":"P Brandtzaeg","year":"1990","unstructured":"Brandtzaeg P, Joo GB, Brusletto B, Kierulf P. Plasminogen activator inhibitor 1 and 2, alpha-2-antiplasmin, plasminogen, and endotoxin levels in systemic meningococcal disease. Thromb Res. 1990;57(2):271\u20138.","journal-title":"Thromb Res"},{"issue":"4","key":"14031_CR45","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1161\/ATVBAHA.107.160168","volume":"28","author":"L Brazionis","year":"2008","unstructured":"Brazionis L, Rowley K, Jenkins A, Itsiopoulos C, O\u2019Dea K. Plasminogen activator inhibitor-1 activity in type 2 diabetes: a different relationship with coronary heart disease and diabetic retinopathy. Arterioscler Thromb Vasc Biol. 2008;28(4):786\u201391.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"14031_CR46","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.2337\/dc12-0638","volume":"35","author":"DJ Schneider","year":"2012","unstructured":"Schneider DJ, Sobel BE. PAI-1 and diabetes: a journey from the bench to the bedside. Diabetes Care. 2012;35(10):1961\u20137.","journal-title":"Diabetes Care"},{"issue":"10","key":"14031_CR47","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.1210\/jc.2006-0525","volume":"91","author":"DA van Waardenburg","year":"2006","unstructured":"van Waardenburg DA, Jansen TC, Vos GD, Buurman WA. Hyperglycemia in children with meningococcal sepsis and septic shock: the relation between plasma levels of insulin and inflammatory mediators. J Clin Endocrinol Metab. 2006;91(10):3916\u201321.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"14031_CR48","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.arcmed.2019.05.003","volume":"50","author":"JF Varona","year":"2019","unstructured":"Varona JF, Ortiz-Regalon R, Sanchez-Vera I, Lopez-Melgar B, Garcia-Durango C, Castellano Vazquez JM, Solis J, Fernandez-Friera L, Vidal-Vanaclocha F. Soluble ICAM 1 and VCAM 1 Blood Levels Alert on Subclinical Atherosclerosis in Non Smokers with Asymptomatic Metabolic Syndrome. Arch Med Res. 2019;50(2):20\u20138.","journal-title":"Arch Med Res"},{"key":"14031_CR49","doi-asserted-by":"crossref","unstructured":"Tate AR, Rao GHR. Inflammation: is it a healer, confounder, or a promoter of cardiometabolic risks? Biomolecules. 2024;14(8).","DOI":"10.3390\/biom14080948"},{"issue":"12","key":"14031_CR50","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1111\/j.1538-7836.2008.03181.x","volume":"6","author":"K Suzuki","year":"2008","unstructured":"Suzuki K. The multi-functional serpin, protein C inhibitor: beyond thrombosis and hemostasis. J Thromb Haemost. 2008;6(12):2017\u201326.","journal-title":"J Thromb Haemost"}],"container-title":["BMC Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-14031-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-14031-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12879-026-14031-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:22:03Z","timestamp":1792005723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12879-026-14031-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["14031"],"URL":"https:\/\/doi.org\/10.1186\/s12879-026-14031-w","relation":{},"ISSN":["1471-2334"],"issn-type":[{"value":"1471-2334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"7 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"These data were included anonymously in the database after excluding personal data as part of the mission of the National Reference Centre for meningococci and\n                      Haemophilus influenzae\n                      (NRCMHi) for routine surveillance of IMD and isolate identification and typing. The procedure for collecting samples and information was submitted and approved by the CNIL N\u00b01475242\/2011 165 (\n                      Commission Nationale de l\u2019Informatique et des Libert\u00e9s) and\n                      the requirement for consent to participate was waived. Animal work The study was carried out in strict accordance with the European Union Directive 2010\/63\/EU (and its revision 86\/609\/EEC) on the protection of animals used for scientific purposes and under the administrative authorization for animal experimentation (Permit Number 75-1554) and the approval of the Institut Pasteur Board (Dap210087\/N\u00b0APAFIS #34085-2021112212171298 v1). The protocol was approved by the Institut Pasteur Review Board that is part of the Regional Committee of Ethics of Animal Experiments of Paris Region (Protocol 23.133_AC456).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Authors works at the unit of invasive bacterial infections at the Institut Pasteur, Paris, France.","order":3,"name":"Ethics","label":"Author information","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"1800"}}