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Given the association between IE and renal involvement, we evaluated whether routine urinalysis could serve as a simple adjunctive tool to aid early clinical assessment in this setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed adults with vegetation-like echocardiographic findings at a tertiary center between 2010 and 2024. Patients were classified as those with confirmed IE [IE (+)] and those in whom IE was ultimately excluded [IE (\u2013)]. Urinalysis parameters at presentation were analyzed, and a simple additive score was constructed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 459 patients were included, comprising 202 with IE (+) and 257 with IE (\u2013). Proteinuria, hematuria, and pyuria were more frequent in IE (+) and remained independently associated with IE in multivariable analysis. An additive score incorporating these variables (1 point each; range 0\u20133) demonstrated acceptable discriminatory ability (area under the curve, 0.77; 95% CI, 0.72\u20130.81). A score of 0 showed a relatively high sensitivity (78%) with acceptable specificity (67%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The absence of hematuria, proteinuria, and pyuria on routine urinalysis may serve as a supportive adjunct\u2014not a rule-out test\u2014for early clinical assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12879-026-14072-1","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T09:29:29Z","timestamp":1784798969000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Routine urinalysis for early clinical assessment in patients with vegetation-like echocardiographic findings"],"prefix":"10.1186","volume":"26","author":[{"given":"Kilyoon","family":"Pack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Eun","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeil","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook-Jin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Seung","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonggeun","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"issue":"4","key":"14072_CR1","doi-asserted-by":"publisher","first-page":"100154","DOI":"10.1016\/j.shj.2022.100154","volume":"7","author":"R Kurmann","year":"2023","unstructured":"Kurmann R, El-Am E, Ahmad A, Abbasi MA, Mazur P, Akiki E, et al. 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