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The aim of the study was to explore the ability of AB US to detect and diagnose mammographically Breast Imaging Reporting and Data System (BI-RADS) category 4 microcalcifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>575 pathologically confirmed mammographically BI-RADS category 4 microcalcifications from January 2017 to June 2021 were included. All patients also completed AB US examinations. Based on the final pathological results, analyzed and summarized the AB US image features, and compared the evaluation results with mammography, to explore the detection and diagnostic ability of AB US for these suspicious microcalcifications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      250 were finally confirmed as malignant and 325 were benign. Mammographic findings including microcalcifications morphology (61\/80 with amorphous, coarse heterogeneous and fine pleomorphic, 13\/14 with fine-linear or branching), calcification distribution (189\/346 with grouped, 40\/67 with linear and segmental), associated features (70\/96 with asymmetric shadow), higher BI-RADS category with 4B (88\/120) and 4\u00a0C (73\/38) showed higher incidence in malignant lesions, and were the independent factors associated with malignant microcalcifications. 477 (477\/575, 83.0%) microcalcifications were detected by AB US, including 223 malignant and 254 benign, with a significantly higher detection rate for malignant lesions (\n                      <jats:italic>x<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200912.20,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Logistic regression analysis showed microcalcifications with architectural distortion (odds ratio [OR]\u2009=\u20090.30,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.014), with amorphous, coarse heterogeneous and fine pleomorphic morphology (OR\u2009=\u20093.15,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037), grouped (OR\u2009=\u20091.90,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.017), liner and segmental distribution (OR\u2009=\u20098.93,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004) were the independent factors which could affect the detectability of AB US for microcalcifications. In AB US, malignant calcification was more frequent in a mass (104\/154) or intraductal (20\/32), and with ductal changes (30\/41) or architectural distortion (58\/68), especially with the both (12\/12). BI-RADS category results also showed that AB US had higher sensitivity to malignant calcification than mammography (64.8% vs. 46.8%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AB US has good detectability for mammographically BI-RADS category 4 microcalcifications, especially for malignant lesions. Malignant calcification is more common in a mass and intraductal in AB US, and tend to associated with architectural distortion or duct changes. Also, AB US has higher sensitivity than mammography to malignant microcalcification, which is expected to become an effective supplementary examination method for breast microcalcifications, especially in dense breasts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12880-024-01287-4","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T17:06:19Z","timestamp":1716915979000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection and diagnosis of automated breast ultrasound in patients with BI-RADS category 4 microcalcifications: a retrospective study"],"prefix":"10.1186","volume":"24","author":[{"given":"Li-Fang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Chao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo-Xi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ju","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Xiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Yun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"1287_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5937\/mp68-15475","volume":"68","author":"V Sarac","year":"2017","unstructured":"Sarac V, Nadrljanski M. 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This study was conducted in accordance with the granted Hangzhou First People\u2019s Hospital ethical approval, and written informed consent was exempted by its Institutional Review Board due to the retrospective nature of the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}