{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:19:25Z","timestamp":1783685965468,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12882-017-0732-1","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T11:09:18Z","timestamp":1508324958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-2618","authenticated-orcid":false,"given":"Sae","family":"Aratani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumika","family":"Taki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Futatsuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Tsuruoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,18]]},"reference":[{"key":"732_CR1","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM200005253422107","volume":"342","author":"HJ Adrogue","year":"2000","unstructured":"Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342:1581\u20139.","journal-title":"N Engl J Med"},{"key":"732_CR2","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-13-1020","volume":"170","author":"G Spasovski","year":"2014","unstructured":"Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol. 2014;170:G1\u201347.","journal-title":"Eur J Endocrinol"},{"key":"732_CR3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ndt\/gfi082","volume":"21","author":"EJ Hoorn","year":"2006","unstructured":"Hoorn EJ, Lindemans J, Zietse R. Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant. 2006;21:70\u20136.","journal-title":"Nephrol Dial Transplant"},{"key":"732_CR4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0885066614566794","volume":"31","author":"MA Buffington","year":"2016","unstructured":"Buffington MA, Abreo K. Hyponatremia: a review. J Intensive Care Med. 2016;31:223\u201336.","journal-title":"J Intensive Care Med"},{"key":"732_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-014-0231-1","volume":"12","author":"EV Nagler","year":"2014","unstructured":"Nagler EV, Vanmassenhove J, van der Veer SN, Nistor I, Van Biesen W, Webster AC, et al. Diagnosis and treatment of hyponatremia: a systematic review of clinical practice guidelines and consensus statements. BMC Med. 2014;12:1.","journal-title":"BMC Med"},{"key":"732_CR6","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1681\/ASN.2016101139","volume":"28","author":"EJ Hoorn","year":"2017","unstructured":"Hoorn EJ, Zietse R. Diagnosis and Treatment of Hyponatremia: Compilation of the Guidelines. J Am Soc Nephrol. 2017;28:1340\u20139.","journal-title":"J Am Soc Nephrol."},{"issue":"10 Suppl 1","key":"732_CR7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","volume":"126","author":"JG Verbalis","year":"2013","unstructured":"Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH, et al. Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med. 2013;126(10 Suppl 1):S1\u201342.","journal-title":"Am J Med"},{"key":"732_CR8","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1056\/NEJM198606123142401","volume":"314","author":"AI Arieff","year":"1986","unstructured":"Arieff AI. Hyponatremia, convulsions, respiratory arrest, and permanent brain damage after elective surgery in healthy women. N Engl J Med. 1986;314:1529\u201335.","journal-title":"N Engl J Med"},{"key":"732_CR9","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJM198606123142402","volume":"314","author":"RH Sterns","year":"1986","unstructured":"Sterns RH, Riggs JE, Schochet SS Jr. Osmotic demyelination syndrome following correction of hyponatremia. N Engl J Med. 1986;314:1535\u201342.","journal-title":"N Engl J Med"},{"key":"732_CR10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1053\/j.ajkd.2012.11.032","volume":"61","author":"L Sood","year":"2013","unstructured":"Sood L, Sterns RH, Hix JK, Silver SM, Chen L. Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia. Am J Kidney Dis. 2013;61:571\u20138.","journal-title":"Am J Kidney Dis"},{"key":"732_CR11","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2215\/CJN.00950113","volume":"9","author":"C Rafat","year":"2014","unstructured":"Rafat C, Schortgen F, Gaudry S, Bertrand F, Miguel-Montanes R, Labbe V, et al. Use of desmopressin acetate in severe hyponatremia in the intensive care unit. Clin J Am Soc Nephrol. 2014;9:229\u201337.","journal-title":"Clin J Am Soc Nephrol"},{"key":"732_CR12","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2215\/CJN.03190807","volume":"3","author":"A Perianayagam","year":"2008","unstructured":"Perianayagam A, Sterns RH, Silver SM, Grieff M, Mayo R, Hix J, Kouides R. DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia. Clin J Am Soc Nephrol. 2008;3:331\u20136.","journal-title":"Clin J Am Soc Nephrol"},{"key":"732_CR13","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ki.2009.254","volume":"76","author":"F Gankam Kengne","year":"2009","unstructured":"Gankam Kengne F, Soupart A, Pochet R, Brion JP, Decaux G. Re-induction of hyponatremia after rapid overcorrection of hyponatremia reduces mortality in rats. Kidney Int. 2009;76:614\u201321.","journal-title":"Kidney Int"},{"key":"732_CR14","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.2215\/CJN.00910207","volume":"2","author":"HK Mohmand","year":"2007","unstructured":"Mohmand HK, Issa D, Ahmad Z, Cappuccio JD, Kouides RW, Sterns RH. Hypertonic saline for hyponatremia: risk of inadvertent overcorrection. Clin J Am Soc Nephrol. 2007;2:1110\u20137.","journal-title":"Clin J Am Soc Nephrol"},{"key":"732_CR15","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-107-5-656","volume":"107","author":"RH Sterns","year":"1987","unstructured":"Sterns RH. Severe symptomatic hyponatremia: treatment and outcome. A study of 64 cases. Ann Intern Med. 1987;107:656\u201364.","journal-title":"Ann Intern Med"},{"key":"732_CR16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ana.410270110","volume":"27","author":"JE Brunner","year":"1990","unstructured":"Brunner JE, Redmond JM, Haggar AM, Kruger DF, Elias SB. Central pontine myelinolysis and pontine lesions after rapid correction of hyponatremia: a prospective magnetic resonance imaging study. Ann Neurol. 1990;27:61\u20136.","journal-title":"Ann Neurol"},{"key":"732_CR17","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1681\/ASN.V481522","volume":"4","author":"RH Sterns","year":"1994","unstructured":"Sterns RH, Cappuccio JD, Silver SM, Cohen EP. Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective. J Am Soc Nephrol. 1994;4:1522\u201330.","journal-title":"J Am Soc Nephrol"},{"key":"732_CR18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ki.1989.9","volume":"35","author":"RH Sterns","year":"1989","unstructured":"Sterns RH, Thomas DJ, Herndon RM. Brain dehydration and neurologic deterioration after rapid correction of hyponatremia. Kidney Int. 1989;35:69\u201375.","journal-title":"Kidney Int"},{"key":"732_CR19","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.mayocp.2015.07.014","volume":"90","author":"P Geoghegan","year":"2015","unstructured":"Geoghegan P, Harrison AM, Thongprayoon C, Kashyap R, Ahmed A, Dong Y, et al. Sodium correction practice and clinical outcomes in profound Hyponatremia. Mayo Clin Proc. 2015;90:1348\u201355.","journal-title":"Mayo Clin Proc"},{"key":"732_CR20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archneurpsyc.1959.02340140020004","volume":"81","author":"RD Adams","year":"1959","unstructured":"Adams RD, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholic and malnourished patients. AMA Arch Neurol Psychiatry. 1959;81:154\u201372.","journal-title":"AMA Arch Neurol Psychiatry"},{"key":"732_CR21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/0002-9343(94)90166-X","volume":"96","author":"JW Lohr","year":"1994","unstructured":"Lohr JW. Osmotic demyelination syndrome following correction of hyponatremia: association with hypokalemia. Am J Med. 1994;96:408\u201313.","journal-title":"Am J Med"},{"key":"732_CR22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000242426","volume":"62","author":"EM Lee","year":"2009","unstructured":"Lee EM, Kang JK, Yun SC, Kim KH, Kim SJ, Hwang KS, et al. Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation. Eur Neurol. 2009;62:362\u20138.","journal-title":"Eur Neurol"},{"key":"732_CR23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ki.2012.459","volume":"83","author":"F Gankam-Kengne","year":"2013","unstructured":"Gankam-Kengne F, Ayers C, Khera A, de Lemos J, Maalouf NM. Mild hyponatremia is associated with an increased risk of death in an ambulatory setting. Kidney Int. 2013;83:700\u20136.","journal-title":"Kidney Int"},{"key":"732_CR24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/EJE-15-0111","volume":"173","author":"L Holland-Bill","year":"2015","unstructured":"Holland-Bill L, Christiansen CF, Heide-Jorgensen U, Ulrichsen SP, Ring T, Jorgensen JO, Sorensen HT. Hyponatremia and mortality risk: a Danish cohort study of 279 508 acutely hospitalized patients. Eur J Endocrinol. 2015;173:71\u201381.","journal-title":"Eur J Endocrinol"},{"key":"732_CR25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3810\/hp.2009.12.266","volume":"37","author":"T Vu","year":"2009","unstructured":"Vu T, Wong R, Hamblin PS, Zajac J, Grossmann M. Patients presenting with severe hypotonic hyponatremia: etiological factors, assessment, and outcomes. Hosp Pract (1995). 2009;37:128\u201336.","journal-title":"Hosp Pract (1995)"},{"key":"732_CR26","first-page":"956","volume":"56","author":"V Agrawal","year":"2008","unstructured":"Agrawal V, Agarwal M, Joshi SR, Ghosh AK. Hyponatremia and hypernatremia: disorders of water balance. J Assoc Physicians India. 2008;56:956\u201364.","journal-title":"J Assoc Physicians India"},{"key":"732_CR27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00000441-200205000-00005","volume":"323","author":"SH Lin","year":"2002","unstructured":"Lin SH, Chau T, Wu CC, Yang SS. Osmotic demyelination syndrome after correction of chronic hyponatremia with normal saline. Am J Med Sci. 2002;323:259\u201362.","journal-title":"Am J Med Sci"},{"key":"732_CR28","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00007611-198605000-00028","volume":"79","author":"B Mozes","year":"1986","unstructured":"Mozes B, Pines A, Werner D, Olchovsky D, Lieberman P, Frankl O. Thiazide-induced hyponatremia: an unusual neurologic course. South Med J. 1986;79:629\u201331.","journal-title":"South Med J"},{"key":"732_CR29","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1681\/ASN.2012020128","volume":"23","author":"HJ Adrogue","year":"2012","unstructured":"Adrogue HJ, Madias NE. The challenge of hyponatremia. J Am Soc Nephrol. 2012;23:1140\u20138.","journal-title":"J Am Soc Nephrol"},{"key":"732_CR30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/qjmed\/hci081","volume":"98","author":"EJ Hoorn","year":"2005","unstructured":"Hoorn EJ, Halperin ML, Zietse R. Diagnostic approach to a patient with hyponatraemia: traditional versus physiology-based options. QJM. 2005;98:529\u201340.","journal-title":"QJM"},{"key":"732_CR31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.amjmed.2010.01.013","volume":"123","author":"W Fenske","year":"2010","unstructured":"Fenske W, Maier SK, Blechschmidt A, Allolio B, Stork S. Utility and limitations of the traditional diagnostic approach to hyponatremia: a diagnostic study. Am J Med. 2010;123:652\u20137.","journal-title":"Am J Med"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-017-0732-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T20:34:45Z","timestamp":1659645285000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-017-0732-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["732"],"URL":"https:\/\/doi.org\/10.1186\/s12882-017-0732-1","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,18]]},"article-number":"316"}}