{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:21:27Z","timestamp":1790734887982,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This study was supported by the National Natural Science Foundation of China","award":["No. 81560125"],"award-info":[{"award-number":["No. 81560125"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12882-018-0852-2","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T12:13:21Z","timestamp":1521029601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Expression of brain-derived neurotrophic factor in kidneys from normal and cyclosporine-treated rats"],"prefix":"10.1186","volume":"19","author":[{"given":"Yuan Sheng","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang Guo","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying Shun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Zhe","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Lan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Woo","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Woo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9412-4412","authenticated-orcid":false,"given":"Can","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"852_CR1","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1212\/WNL.0000000000001507","volume":"84","author":"EE Benarroch","year":"2015","unstructured":"Benarroch EE. Brain-derived neurotrophic factor: regulation, effects, and potential clinical relevance. Neurology. 2015;84:1693\u2013704.","journal-title":"Neurology"},{"key":"852_CR2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.4331\/wjbc.v5.i4.409","volume":"5","author":"N Adachi","year":"2014","unstructured":"Adachi N, Numakawa T, Richards M, Nakajima S, Kunugi H. New insight in expression, transport, and secretion of brain-derived neurotrophic factor: implications in brain-related diseases. World J Biol Chem. 2014;5:409\u201328.","journal-title":"World J Biol Chem"},{"key":"852_CR3","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.yjmcc.2007.10.019","volume":"44","author":"M Kreusser","year":"2008","unstructured":"Kreusser M, Buss S, Krebs J, Kinscherf R, Metz J, Katus H, et al. Differential expression of cardiac neurotrophic factors and sympathetic nerve ending abnormalities within the failing heart. J Mol Cell Cardiol. 2008;44:380\u20137.","journal-title":"J Mol Cell Cardiol"},{"key":"852_CR4","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/BF02532343","volume":"21","author":"M Yamamoto","year":"1996","unstructured":"Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res. 1996;21:929\u201338.","journal-title":"Neurochem Res"},{"key":"852_CR5","doi-asserted-by":"publisher","first-page":"F277","DOI":"10.1152\/ajprenal.90602.2008","volume":"296","author":"H Pan","year":"2009","unstructured":"Pan H, Kerns J, Lin D, Sypert D, Steward J, Hoover CRV, et al. Dual simulated childbirth injury delays anatomic recovery. Am J Physiol Renal Physiol. 2009;296:F277\u201383.","journal-title":"Am J Physiol Renal Physiol."},{"key":"852_CR6","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1016\/j.bbamcr.2013.07.019","volume":"1833","author":"P Vohra","year":"2013","unstructured":"Vohra P, Thompson M, Sathish V, Kiel A, Jerde C, Pabelick C, et al. TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle. Biochim Biophys Acta. 2013;1833:2953\u201360.","journal-title":"Biochim Biophys Acta"},{"key":"852_CR7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.ydbio.2003.12.001","volume":"267","author":"A Paredes","year":"2004","unstructured":"Paredes A, Romero C, Dissen G, DeChiara T, Reichardt L, Cornea A, et al. TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary. Dev Biol. 2004;267:430\u201349.","journal-title":"Dev Biol"},{"key":"852_CR8","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1006\/dbio.1996.0268","volume":"179","author":"LJ Huber","year":"1996","unstructured":"Huber LJ, Hempstead B, Donovan MJ. Neurotrophin and neurotrophin receptors in human fetal kidney. Dev Biol. 1996;179:369\u201381.","journal-title":"Dev Biol"},{"key":"852_CR9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/nrneph.2009.113","volume":"5","author":"C Li","year":"2009","unstructured":"Li C, Yang CW. The pathogenesis and treatment of chronic allograft nephropathy. Nat Rev Nephrol. 2009;5:513\u20139.","journal-title":"Nat Rev Nephrol"},{"key":"852_CR10","doi-asserted-by":"publisher","first-page":"F139","DOI":"10.1152\/ajprenal.00240.2003","volume":"287","author":"SW Lim","year":"2004","unstructured":"Lim SW, Li C, Sun BK, Han KH, Kim WY, Oh YW, et al. Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney. Am J Physiol Renal Physiol. 2004;287:F139\u201351.","journal-title":"Am J Physiol Renal Physiol"},{"key":"852_CR11","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3349\/ymj.2004.45.6.1004","volume":"45","author":"C Li","year":"2004","unstructured":"Li C, Lim SW, Sun BK, Yang CW. Chronic cyclosporine nephrotoxicity: new insights and preventive strategies. Yonsei Med J. 2004;45:1004\u201316.","journal-title":"Yonsei Med J"},{"key":"852_CR12","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0306-4522(01)00225-1","volume":"105","author":"K Miyata","year":"2001","unstructured":"Miyata K, Omori N, Uchino H, Yamaguchi T, Isshiki A, Shibasaki F. Involvement of the brain-derived neurotrophic factor\/TrkB pathway in neuroprotecive effect of cyclosporin a in forebrain ischemia. Neuroscience. 2001;105:571\u20138.","journal-title":"Neuroscience"},{"key":"852_CR13","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.cellbi.2009.04.006","volume":"33","author":"B Gabryel","year":"2009","unstructured":"Gabryel B, Bernachi J. Effect of FK506 and cyclosporine a on the expression of BDNF, tyrosine kinase B and p75 neurotrophin receptors in astrocytes exposed to simulated ischemia in vitro. Cell Biol Int. 2009;33:739\u201348.","journal-title":"Cell Biol Int"},{"key":"852_CR14","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s11064-010-0160-0","volume":"35","author":"CC Chen","year":"2010","unstructured":"Chen CC, Hsu LW, Huang LT, Huang TL. Chronic administration of cyclosporine a changes expression of BDNF and TrkB in rat hippocampus and midbrain. Neurochem Res. 2010;35:1098\u2013104.","journal-title":"Neurochem Res"},{"key":"852_CR15","first-page":"F724","volume":"275","author":"TH Kwon","year":"1998","unstructured":"Kwon TH, Fr\u00f8kiaer J, Knepper MA, Nielsen S. Reduced AQP1, \u22122, and \u22123 levels inkidneys of rats with CRF induced by surgical reduction in renal mass. Am J Phys. 1998;275:F724\u201341.","journal-title":"Am J Phys"},{"key":"852_CR16","doi-asserted-by":"publisher","first-page":"e72685","DOI":"10.1371\/journal.pone.0072685","volume":"8","author":"SW Lim","year":"2013","unstructured":"Lim SW, Doh KC, Jin L, Jin J, Piao SG, Heo SB, et al. Oral administration of ginseng ameliorates cyclosporine-induced pancreatic injury in an experimental mouse model. PLoS One. 2013;8:e72685.","journal-title":"PLoS One"},{"key":"852_CR17","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.transproceed.2013.12.047","volume":"46","author":"DM Lei","year":"2014","unstructured":"Lei DM, Piao SG, Jin YS, Cui ZH, Jin HF, Jin JZ, et al. Expression of erythropoietin and its receptor in kidneys from normal and cyclosporine-treated rats. Transplant Proc. 2014;46:521\u20138.","journal-title":"Transplant Proc"},{"key":"852_CR18","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/TP.0b013e318296c9a9","volume":"96","author":"SG Piao","year":"2013","unstructured":"Piao SG, Kang SH, Lim SW, Chung B, Doh KC, Heo SB, et al. Influence of N-acetylcysteine on klotho expression and its signaling pathway in experimental model of chronic cyclosporine nephropathy in mice. Transplantation. 2013;96:146\u201353.","journal-title":"Transplantation"},{"key":"852_CR19","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/TP.0b013e3181820470","volume":"86","author":"KO Ahn","year":"2008","unstructured":"Ahn KO, Li C, Lim SW, Song HK, Ghee JY, Kim SH, et al. Infiltration of nestin-expressing cells in interstitial fibrosis in chronic cyclosporine nephropathy. Transplantation. 2008;86:571\u20137.","journal-title":"Transplantation"},{"key":"852_CR20","first-page":"1807","volume":"148","author":"E Shibayama","year":"1996","unstructured":"Shibayama E, Koizumi H. Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol. 1996;148:1807\u201318.","journal-title":"Am J Pathol"},{"key":"852_CR21","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s004290050330","volume":"201","author":"P De Girolamo","year":"2000","unstructured":"De Girolamo P, Arcamone N, Lucini C, Castaldo L, Vega JA, Gargiulo G. The teleost kidney expresses Trk neurotrophin receptor-like proteins. Anat Embryol. 2000;201:429\u201333.","journal-title":"Anat Embryol"},{"key":"852_CR22","doi-asserted-by":"crossref","unstructured":"De Girolamo P, Arcamone N, Lucini C,Simeoli MP, Castaldo L, Gargiulo G. TRK neurotrophin receptor-like proteins in the kidney of frog (Rana esculenta) and lizard (Podarcis sicula): an immunohistochemical study. AnatEmbryol 2004; 207: 481\u2013487.","DOI":"10.1007\/s00429-003-0364-z"},{"key":"852_CR23","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1046\/j.1523-1755.2000.00999.x","volume":"57","author":"A Amore","year":"2000","unstructured":"Amore A, Emancipator SN, Cirina P, Conti G, Ricotti E, Bagheri N, et al. Nitric oxide mediates cyclosporine-induced apoptosis in cultured renal cells. Kidney Int. 2000;57:1549\u201359.","journal-title":"Kidney Int"},{"key":"852_CR24","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1097\/TP.0b013e31825ace5c","volume":"94","author":"SW Lim","year":"2012","unstructured":"Lim SW, Hyoung BJ, Piao SG, Doh KC, Chung BH, Yang CW. Chronic cyclosporine nephropathy is characterized by excessive autophagosome formation and decreased autophagic clearance. Transplantation. 2012;94:218\u201325.","journal-title":"Transplantation"},{"key":"852_CR25","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.toxlet.2013.01.007","volume":"218","author":"G De Arriba","year":"2013","unstructured":"De Arriba G, Calvino M, Benito S, Parra T. Cyclosporine A-induced apoptosis in renal tubular cells is related to oxidative damage and mitochondrial fission. Toxicol Lett. 2013;218:30\u20138.","journal-title":"Toxicol Lett"},{"key":"852_CR26","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1142\/S0192415X12500425","volume":"40","author":"S Zhu","year":"2012","unstructured":"Zhu S, Wang Y, Chen M, Jin J, Qiu Y, Huang M, et al. Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med. 2012;40:551\u201366.","journal-title":"Am J Chin Med"},{"key":"852_CR27","doi-asserted-by":"publisher","first-page":"e59693","DOI":"10.1371\/journal.pone.0059693","volume":"8","author":"BH Chung","year":"2013","unstructured":"Chung BH, Lim SW, Doh KC, Piao SG, Heo SB, Yang CW. Human adipose tissue derived mesenchymal stem cells aggravate chronic cyclosporin nephrotoxicity by the induction of oxidative stress. PLoS One. 2013;8:e59693.","journal-title":"PLoS One"},{"key":"852_CR28","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s00467-008-0903-1","volume":"23","author":"B Kasap","year":"2008","unstructured":"Kasap B, Soylu A, Kuralay F, Sarioglu S, Kiray M, Tu\u011fyan K, et al. Protective effect of Epo on oxidative renal injury in rats with cyclosporine nephrotoxicity. Pediatr Nephrol. 2008;23:1991\u20139.","journal-title":"Pediatr Nephrol"},{"key":"852_CR29","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1096\/fasebj.8.10.8050673","volume":"8","author":"R Klein","year":"1994","unstructured":"Klein R. Role of neurotrophins in mouse neuronal development. FASEB J. 1994;8:738\u201344.","journal-title":"FASEB J"},{"key":"852_CR30","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1007\/s10072-014-1862-x","volume":"35","author":"X Song","year":"2014","unstructured":"Song X, Lian D, He D, Sun J, Zhu M, Li L. The responsiveness of TrkB to exogenous BDNF in frontal cortex during antibiotic treatment of Streptococcus pneumoniae meningitis. Neurol Sci. 2014;35:1915\u201323.","journal-title":"Neurol Sci"},{"key":"852_CR31","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.1007\/s00213-015-3924-z","volume":"232","author":"BB Wetzell","year":"2015","unstructured":"Wetzell BB, Muller M, Flax S, King H, DeCicco Skinner K, Riley A. Effect of preexposure on methylphenidate-induced taste avoidance and related BDNF\/TrkB activity in the insular cortex of the rat. Psychopharmacology. 2015;232:2837\u201347.","journal-title":"Psychopharmacology"},{"key":"852_CR32","doi-asserted-by":"publisher","first-page":"929","DOI":"10.3233\/JAD-150059","volume":"46","author":"E K\u00e4rkk\u00e4inen","year":"2015","unstructured":"K\u00e4rkk\u00e4inen E, Lahtinen HM, N\u00e4rv\u00e4inen J, Gr\u00f6hn O, Tanila H. Brain amyloidosis and BDNF deficiency have opposite effects on brain volumes in A\u03b2PP\/PS1 mice both in vivo and ex vivo. J Alzheimers Dis. 2015;46:929\u201346.","journal-title":"J Alzheimers Dis"},{"key":"852_CR33","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1681\/ASN.V103647","volume":"10","author":"S Nielsen","year":"1999","unstructured":"Nielsen S, Kwon TH, Christensen BM, Promeneur D, Fr\u00f8kiaer J, Marples D. Physiology and pathophysiology of renal aquaporins. J Am Soc Nephrol. 1999;10:647\u201363.","journal-title":"J Am Soc Nephrol"},{"key":"852_CR34","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1681\/ASN.2006060664","volume":"18","author":"SW Lim","year":"2007","unstructured":"Lim SW, Ahn KO, Sheen MR, Jeon US, Kim J, Yang CW, et al. Downregulation of renal sodium transporters and tonicity-responsive enhancer binding protein by long-term treatment with cyclosporin a. J Am Soc Nephrol. 2007;18:421\u20139.","journal-title":"J Am Soc Nephrol"},{"key":"852_CR35","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuroscience.2012.12.044","volume":"234","author":"B Frias","year":"2013","unstructured":"Frias B, Allen S, Dawbarn D, Charrua A, Cruz F, Cruz CD. Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Neuroscience. 2013;234:88\u2013102.","journal-title":"Neuroscience"},{"key":"852_CR36","doi-asserted-by":"publisher","first-page":"2434","DOI":"10.1097\/01.ju.0000143549.29867.4e","volume":"172","author":"E Murray","year":"2004","unstructured":"Murray E, Malley SE, Qiao LY, Hu VY, Vizzard MA. Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladder. J Urol. 2004;172:2434\u20139.","journal-title":"J Urol"},{"key":"852_CR37","doi-asserted-by":"publisher","first-page":"e115177","DOI":"10.1371\/journal.pone.0115177","volume":"9","author":"A Jim\u00e9nez Maldonado","year":"2014","unstructured":"Jim\u00e9nez Maldonado A, De \u00c1lvarez-Buylla ER, Montero S, Montero S, Melnikov V, Castro Rodr\u00edguez E, et al. Chronic exercise increases plasma brain-derived neurotrophic factor levels, pancreatic islet size, and insulin tolerance in a TrkB-dependent manner. PLoS One. 2014;9:e115177.","journal-title":"PLoS One"},{"key":"852_CR38","doi-asserted-by":"publisher","first-page":"G328","DOI":"10.1152\/ajpgi.00203.2013","volume":"306","author":"M Al Qudah","year":"2014","unstructured":"Al Qudah M, Anderson CD, Mahavadi S, Bradley ZL, Akbarali HI, Murthy KS, et al. Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C. Am J Physiol Gastrointest Liver Physiol. 2014;306:G328\u201337.","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-0852-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12882-018-0852-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-0852-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:43:22Z","timestamp":1660610602000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-018-0852-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["852"],"URL":"https:\/\/doi.org\/10.1186\/s12882-018-0852-2","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]},"assertion":[{"value":"2 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was approved by the Animal Care Committee of the Catholic University of Korea.All animal procedures were approved and conducted in compliance with the Catholic University of Korea animal ethics committee guidelines. Our manuscript reporting adheres to the ARRIVE guidelines in accordance with BioMed Central editorial policies.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"63"}}