{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:25:58Z","timestamp":1762917958892,"version":"3.37.3"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T00:00:00Z","timestamp":1541462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Association pour la promotion \u00e0 Tours de la r\u00e9animation m\u00e9dicale"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12882-018-1091-2","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T03:58:14Z","timestamp":1541476694000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lack of impact of iodinated contrast media on kidney cell-cycle arrest biomarkers in critically ill patients"],"prefix":"10.1186","volume":"19","author":[{"given":"Emmanuelle","family":"Rouve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Lakhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Salmon Gandonni\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youenn","family":"Jouan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Bodet-Contentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-4467","authenticated-orcid":false,"given":"Stephan","family":"Ehrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,6]]},"reference":[{"key":"1091_CR1","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/s00134-015-3934-7","volume":"41","author":"EA Hoste","year":"2015","unstructured":"Hoste EA, Bagshaw SM, Bellomo R, Cely CM, Colman R, Cruz DN, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med. 2015;41:1411\u201323.","journal-title":"Intensive Care Med"},{"key":"1091_CR2","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"Kidney Disease","year":"2012","unstructured":"Kidney Disease. Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. 2012;2:S1\u2013138.","journal-title":"Kidney Int"},{"key":"1091_CR3","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1681\/ASN.2004090740","volume":"16","author":"GM Chertow","year":"2005","unstructured":"Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005;16:3365\u201370.","journal-title":"J Am Soc Nephrol"},{"key":"1091_CR4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/j.1523-1755.2005.00377.x","volume":"68","author":"PB Persson","year":"2005","unstructured":"Persson PB, Hansell P, Liss P. Pathophysiology of contrast medium-induced nephropathy. Kidney Int. 2005;68:14\u201322.","journal-title":"Kidney Int"},{"key":"1091_CR5","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1097\/CCM.0b013e318275871a","volume":"41","author":"S Ehrmann","year":"2013","unstructured":"Ehrmann S, Badin J, Savath L, Pajot O, Garot D, Pham T, et al. Acute kidney injury in the critically ill: is iodinated contrast medium really harmful? Crit Care Med. 2013;41:1017\u201326.","journal-title":"Crit Care Med"},{"key":"1091_CR6","doi-asserted-by":"publisher","first-page":"R67","DOI":"10.1186\/cc11317","volume":"16","author":"CM Cely","year":"2012","unstructured":"Cely CM, Schein RM, Quartin AA. Risk of contrast induced nephropathy in the critically ill: a prospective, case matched study. Crit Care. 2012;16:R67.","journal-title":"Crit Care"},{"key":"1091_CR7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.2214\/AJR.09.4150","volume":"195","author":"CS Ng","year":"2010","unstructured":"Ng CS, Shaw AD, Bell CS, Samuels JA. Effect of IV contrast medium on renal function in oncologic patients undergoing CT in ICU. AJR Am J Roentgenol. 2010;195:414\u201322.","journal-title":"AJR Am J Roentgenol"},{"key":"1091_CR8","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00134-017-4700-9","volume":"43","author":"S Ehrmann","year":"2017","unstructured":"Ehrmann S, Quartin A, Hobbs BP, Robert-Edan V, Cely C, Bell C, et al. Contrast-associated acute kidney injury in the critically ill: systematic review and Bayesian meta-analysis. Intensive Care Med. 2017;43:785\u201394.","journal-title":"Intensive Care Med"},{"key":"1091_CR9","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1007\/s00134-017-4699-y","volume":"43","author":"JS McDonald","year":"2017","unstructured":"McDonald JS, McDonald RJ, Williamson EE, Kallmes DF, Kashani K. Post-contrast acute kidney injury in intensive care unit patients: a propensity score-adjusted study. Intensive Care Med. 2017;43:774\u201384.","journal-title":"Intensive Care Med"},{"key":"1091_CR10","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.annemergmed.2016.11.021","volume":"69","author":"JS Hinson","year":"2017","unstructured":"Hinson JS, Ehmann MR, Fine DM, Fishman EK, Toerper MF, Rothman RE, et al. Risk of acute kidney injury after intravenous contrast media administration. Ann Emerg Med. 2017;69:577\u201386.","journal-title":"Ann Emerg Med"},{"key":"1091_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1148\/radiol.13130775","volume":"271","author":"JS McDonald","year":"2014","unstructured":"McDonald JS, McDonald RJ, Carter RE, Katzberg RW, Kalmes DF, Williamson EE. Risk of intravenous contrast material-mediated acute kidney injury: a propensity score-matched study stratified by baseline-estimated glomerular filtration rate. Radiology. 2014;271:65\u201373.","journal-title":"Radiology"},{"key":"1091_CR12","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1148\/radiol.14132418","volume":"273","author":"RJ McDonald","year":"2014","unstructured":"McDonald RJ, McDonald JS, Carter RE, Hartman RP, Katzberg RW, Kallmes DF, et al. Intravenous contrast material exposure is not an independent risk factor for dialysis or mortality. Radiology. 2014;273:714\u201325.","journal-title":"Radiology"},{"key":"1091_CR13","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/cc12503","volume":"17","author":"K Kashani","year":"2013","unstructured":"Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013;17:R25.","journal-title":"Crit Care"},{"key":"1091_CR14","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1164\/rccm.201401-0077OC","volume":"189","author":"A Bihorac","year":"2014","unstructured":"Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, et al. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am J Respir Crit Care Med. 2014;189:932\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"1091_CR15","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","volume":"61","author":"E Von Elm","year":"2008","unstructured":"Von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP, Initiative STROBE. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344\u20139.","journal-title":"J Clin Epidemiol"},{"key":"1091_CR16","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1093\/ndt\/gfu292","volume":"29","author":"EA Hoste","year":"2014","unstructured":"Hoste EA, McCullough PA, Kashani K, Chawla LS, Joannidis M, Shaw AD, et al. Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. Nephrol Dial Transplant. 2014;29:2054\u201361.","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"1091_CR17","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1007\/s00134-016-4670-3","volume":"43","author":"Melanie Meersch","year":"2017","unstructured":"Meersch M, Schmidt C, Hoffmeier A, Van Aken H, Wempe C, Gerss J, et al. Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients indentified by biomarkers: the PrevAKI randomized controlled trial. Intensive Care Med. 2017. \n                    https:\/\/doi.org\/10.1007\/s00134-016-4670-3\n                    \n                  .","journal-title":"Intensive Care Medicine"},{"key":"1091_CR18","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.jcrc.2011.05.010","volume":"26","author":"K Lakhal","year":"2011","unstructured":"Lakhal K, Ehrmann S, Chaari A, Laissy JP, R\u00e9gnier B, Wolff M, et al. Acute kidney injury network definition of contras-induced nephropathy in the critically ill: incidence and outcome. J Crit Care. 2011;26:593\u20139.","journal-title":"J Crit Care"},{"key":"1091_CR19","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1681\/ASN.2006010017","volume":"17","author":"P Devarajan","year":"2006","unstructured":"Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17:1503\u201320.","journal-title":"J Am Soc Nephrol"},{"key":"1091_CR20","first-page":"459","volume":"58","author":"QH Yang","year":"2009","unstructured":"Yang QH, Liu DW, Long Y, Liu HZ, Chai WZ, Wang XT. Acute renal failure during sepsis: potential role of cell cycle regulation. J Inf Secur. 2009;58:459\u201364.","journal-title":"J Inf Secur"},{"key":"1091_CR21","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s00134-013-2826-y","volume":"39","author":"X Valette","year":"2013","unstructured":"Valette X, Savary B, Nowoczyn M, Daubin C, Pottier V, Terzi N, et al. Accuracy of plasma neutrophil gelatinase-associated lipocalin in the early diagnosis of contrast-induced acute kidney injury in critical illness. Intensive Care Med. 2013;39:857\u201365.","journal-title":"Intensive Care Med"},{"key":"1091_CR22","doi-asserted-by":"publisher","first-page":"E88","DOI":"10.25011\/cim.v39i3.26797","volume":"39","author":"M Muratoglu","year":"2016","unstructured":"Muratoglu M, Kavalci C, Kilicli E, Findik M, Kayipmaz AE, Durukan P. Serum neutrophil gelatinase-associated lipocalin levels in early detection of contrast-induced nephropathy. Clin Invest Med. 2016;39:E88\u201394.","journal-title":"Clin Invest Med"},{"key":"1091_CR23","doi-asserted-by":"publisher","first-page":"41300","DOI":"10.1038\/srep41300","volume":"7","author":"W Ribitsch","year":"2017","unstructured":"Ribitsch W, Schilcher G, Quehenberger F, Pilz S, Portugaller RH, Truschnig-Wilders M, et al. Neutrophil gelatinase-associated lipocalin (NGAL) fails as an early predictor of contrast induced nephropathy in chronic kidney disease (ANTI-CI-AKI study). Sci Rep. 2017;7:41300.","journal-title":"Sci Rep"},{"key":"1091_CR24","doi-asserted-by":"publisher","unstructured":"Ostermann M, McCulough PA, Forni LG, Bagshaw SM, Joannidis M, Shi J, Kashani K, Honore PM, Chawla LS, Kellum JA. Kinetics of urinary cell cycle arrest markers for acute kidney injury following exposure to potential renal insults. Crit Care Med. 2017. \n                    https:\/\/doi.org\/10.1097\/CCM0000000000002847\n                    \n                  .","DOI":"10.1097\/CCM0000000000002847"},{"key":"1091_CR25","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12882-015-0203-5","volume":"16","author":"S Pajenda","year":"2015","unstructured":"Pajenda S, Ilhan-Mutlu A, Preusser M, Roka S, Druml W, Wagner L. NephroCheck data compared to serum creatinine in various clinical settings. BMC Nephrol. 2015;16:206.","journal-title":"BMC Nephrol"},{"key":"1091_CR26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.5811\/westjem.2013.11.15343","volume":"15","author":"DB Diercks","year":"2014","unstructured":"Diercks DB, Owen KP, Tolstikov V, Sutter ME, Kline JA. Urinary metabolomics analysis to detect changes after intravenous, non-ionic, low osmolar iodinated radiocontrast for computerized tomographic imaging. West J Emerg Med. 2014;15:152\u20137.","journal-title":"West J Emerg Med"},{"key":"1091_CR27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/TA.0000000000000912","volume":"80","author":"KJ Gunnerson","year":"2016","unstructured":"Gunnerson KJ, Shaw AD, Chawla LS, Bihorac A, Al-Khafaji A, Kashani K, et al. Timp2\u2022IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients. J Trauma Acute Care Surg. 2016;80:243\u20139.","journal-title":"J Trauma Acute Care Surg"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-1091-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12882-018-1091-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-1091-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T19:18:14Z","timestamp":1572981494000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-018-1091-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,6]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1091"],"URL":"https:\/\/doi.org\/10.1186\/s12882-018-1091-2","relation":{},"ISSN":["1471-2369"],"issn-type":[{"type":"electronic","value":"1471-2369"}],"subject":[],"published":{"date-parts":[[2018,11,6]]},"assertion":[{"value":"21 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the ethics board of the French intensive care society (CE SRLF 14\u201316). In accordance with national regulations, patients and\/or relatives were informed about the study and could decline participation, written consent was waived.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"SE received research grants from Fisher & Paykel, Aerogen, Hamilton, Firalis and Consulting\/Lecture fees from La diffusion technique fran\u00e7aise, Aerogen, Baxter, Bayer. KL received lecture fees from Medtronic. Astute medical provided the Nephrocheck\u00ae point of care device free of charge and provided assistance for sample analysis. The company was not involved in study design, analysis nor manuscript drafting. Reagents for measurements were bought by the \u201cAssociation pour la promotion \u00e0 Tours de la r\u00e9animation m\u00e9dicale: APTRM\u201d.ER, KL, CSG, YJ, LBC have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"308"}}