{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:43:54Z","timestamp":1759938234914,"version":"3.37.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12882-018-1180-2","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T12:08:34Z","timestamp":1545048514000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute kidney injury due to thin basement membrane disease mimicking Deferasirox nephrotoxicity: a case report"],"prefix":"10.1186","volume":"19","author":[{"given":"Keiko","family":"Oda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-133X","authenticated-orcid":false,"given":"Kan","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Tanoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Hirabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayasu","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Dohi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"key":"1180_CR1","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1182\/blood-2005-08-3430","volume":"107","author":"MD Cappellini","year":"2006","unstructured":"Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006;107:3455\u201362.","journal-title":"Blood"},{"key":"1180_CR2","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1093\/ndt\/gfn423","volume":"23","author":"G Brosnahan","year":"2008","unstructured":"Brosnahan G, Gokden N, Swaminathan S. Acute interstitial nephritis due to deferasirox: a case report. Nephrol Dial Transplant. 2008;23:3356\u20138.","journal-title":"Nephrol Dial Transplant"},{"key":"1180_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1053\/j.ajkd.2008.03.034","volume":"52","author":"B Yusuf","year":"2008","unstructured":"Yusuf B, McPhedran P, Brewster UC. Hypocalcemia in a dialysis patient treated with deferasirox for iron overload. Am J Kidney Dis. 2008;52:587\u201390.","journal-title":"Am J Kidney Dis"},{"key":"1180_CR4","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1053\/j.ajkd.2009.03.013","volume":"54","author":"C Rafat","year":"2009","unstructured":"Rafat C, Fakhouri F, Ribeil JA, Delarue R, Le Quintrec M. Fanconi syndrome due to deferasirox. Am J Kidney Dis. 2009;54:931\u20134.","journal-title":"Am J Kidney Dis"},{"key":"1180_CR5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajh.21588","volume":"85","author":"E Even-Or","year":"2010","unstructured":"Even-Or E, Becker-Cohen R, Miskin H. Deferasirox treatment may be associated with reversible renal Fanconi syndrome.1. Am J Hematol. 2010;85:132\u20134.","journal-title":"Am J Hematol"},{"key":"1180_CR6","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1093\/ndt\/gfq224","volume":"25","author":"S Grang\u00e9","year":"2010","unstructured":"Grang\u00e9 S, Bertrand DM, Guerrot D, Eas F, Godin M. Acute renal failure and Fanconi syndrome due to deferasirox. Nephrol Dial Transplant. 2010;25:2376\u20138.","journal-title":"Nephrol Dial Transplant"},{"key":"1180_CR7","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1440-1797.2009.01183.x","volume":"15","author":"CT Yew","year":"2010","unstructured":"Yew CT, Talaulikar GS, Falk MC, Clayton P, D'Rozario J, Brown M. Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis. Nephrology (Carlton). 2010;15:377.","journal-title":"Nephrology (Carlton)"},{"key":"1180_CR8","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/pbc.22711","volume":"56","author":"MN Rheault","year":"2011","unstructured":"Rheault MN, Bechtel H, Neglia JP, Kashtan CE. Reversible Fanconi syndrome in a pediatric patient on deferasirox. Pediatr Blood Cancer. 2011;56:674\u20136.","journal-title":"Pediatr Blood Cancer"},{"key":"1180_CR9","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/j.1537-2995.2010.02939.x","volume":"51","author":"HY Wei","year":"2011","unstructured":"Wei HY, Yang CP, Cheng CH, Lo FS. Fanconi syndrome in a patient with \u03b2-thalassemia major after using deferasirox for 27 months. Transfusion. 2011;51:949\u201354.","journal-title":"Transfusion"},{"key":"1180_CR10","first-page":"177","volume":"112","author":"N Murphy","year":"2013","unstructured":"Murphy N, Elramah M, Vats H, Zhong W, Chan MR. A case report of deferasirox-induced kidney injury and Fanconi syndrome. WMJ. 2013;112:177\u201380.","journal-title":"WMJ"},{"key":"1180_CR11","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1111\/jcpt.12553","volume":"42","author":"L Shah","year":"2017","unstructured":"Shah L, Powell JL, Zaritsky JJ. A case of Fanconi syndrome due to a deferasirox overdose and a trial of plasmapheresis. J Clin Pharm Ther. 2017;42:634\u20137.","journal-title":"J Clin Pharm Ther"},{"key":"1180_CR12","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1046\/j.1523-1755.2003.00234.x","volume":"64","author":"J Savige","year":"2003","unstructured":"Savige J, Rana K, Tonna S, Buzza M, Dagher H, Wang YY. Thin basement membrane nephropathy. Kidney Int. 2003;64:1169\u201378.","journal-title":"Kidney Int"},{"key":"1180_CR13","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nrneph.2014.121","volume":"10","author":"JD D\u00edaz-Garc\u00eda","year":"2014","unstructured":"D\u00edaz-Garc\u00eda JD, Gallegos-Villalobos A, Gonzalez-Espinoza L, Sanchez-Ni\u00f1o MD, Villarrubia J, Ortiz A. Deferasirox nephrotoxicity-the knowns and unknowns. Nat Rev Nephrol. 2014;10:574\u201386.","journal-title":"Nat Rev Nephrol"},{"key":"1180_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0344-0338(80)80209-3","volume":"168","author":"GW Richter","year":"1980","unstructured":"Richter GW. Iron overload nephropathy in rats. Pathol Res Pract. 1980;168:84\u2013106.","journal-title":"Pathol Res Pract"},{"key":"1180_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2215\/CJN.01970211","volume":"7","author":"JA Moreno","year":"2012","unstructured":"Moreno JA, Mart\u00edn-Cleary C, Guti\u00e9rrez E, Toldos O, Blanco-Colio LM, Praga M, et al. AKI associated with macroscopic glomerular hematuria: clinical and pathophysiologic consequences. Clin J Am Soc Nephrol. 2012;7:175\u201384.","journal-title":"Clin J Am Soc Nephrol"},{"key":"1180_CR16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/03008200802148280","volume":"49","author":"K Voskarides","year":"2008","unstructured":"Voskarides K, Pierides A, Deltas C. COL4A3\/COL4A4 mutations link familial hematuria and focal segmental glomerulosclerosis. Glomerular epithelium destruction via basement membrane thinning? Connect Tissue Res. 2008;49:283\u20138.","journal-title":"Connect Tissue Res"},{"key":"1180_CR17","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1007\/s00467-008-0934-7","volume":"23","author":"S Tonna","year":"2008","unstructured":"Tonna S, Wang YY, Wilson D, Rigby L, Tabone T, Cotton R, et al. The R229Q mutation in NPHS2 may predispose to proteinuria in thin-basement-membrane nephropathy. Pediatr Nephrol. 2008;23:2201\u20137.","journal-title":"Pediatr Nephrol"},{"key":"1180_CR18","first-page":"207","volume":"17","author":"A Pierides","year":"2013","unstructured":"Pierides A, Voskarides K, Kkolou M, Hadjigavriel M. Deltas C. X-linked, COL4A5 hypomorphic Alport mutations such as G624D and P628L may only exhibit thin basement membrane nephropathy with microhematuria and late onset kidney failure. Hippokratia. 2013;17:207\u201313.","journal-title":"Hippokratia"},{"key":"1180_CR19","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000432406","volume":"130","author":"C Stefanou","year":"2015","unstructured":"Stefanou C, Pieri M, Savva I, Georgiou G, Pierides A, Voskarides K, et al. Co-inheritance of functional Podocin variants with heterozygous collagen IV mutations predisposes to renal failure. Nephron. 2015;130:200\u201312.","journal-title":"Nephron"},{"key":"1180_CR20","doi-asserted-by":"publisher","first-page":"e0174274","DOI":"10.1371\/journal.pone.0174274","volume":"12","author":"K Voskarides","year":"2017","unstructured":"Voskarides K, Stefanou C, Pieri M, Demosthenous P, Felekkis K, Arsali M, et al. A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population. PLoS One. 2017;12:e0174274.","journal-title":"PLoS One"},{"key":"1180_CR21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0272-6386(00)70209-5","volume":"35","author":"AB Abt","year":"2000","unstructured":"Abt AB, Carroll LE, Mohler JH. Thin basement membrane disease and acute renal failure secondary to gross hematuria and tubular necrosis. Am J Kidney Dis. 2000;35:533\u20136.","journal-title":"Am J Kidney Dis"},{"key":"1180_CR22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12882-015-0176-4","volume":"16","author":"AK Lim","year":"2015","unstructured":"Lim AK, Brown S, Simpson I, Dowling JP. Acute kidney injury due to glomerular haematuria and obstructive erythrocyte casts associated with thrombocytopaenia and thin basement membrane disease: a case report. BMC Nephrol. 2015;16:180.","journal-title":"BMC Nephrol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-1180-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12882-018-1180-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-018-1180-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T11:35:15Z","timestamp":1720870515000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-018-1180-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1180"],"URL":"https:\/\/doi.org\/10.1186\/s12882-018-1180-2","relation":{},"ISSN":["1471-2369"],"issn-type":[{"type":"electronic","value":"1471-2369"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"28 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of this case report. A copy of the written consent is available for review by the editor of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"M.I. received departmental scholarship funds of \u22651,000,000 yen per year for direct expenses from MSD K.K., Bristol-Myers Squibb, BIOTORONIK JAPAN, Inc., Astellas Pharma Inc., Shionogi & Co., Ltd., and Otsuka Pharmaceutical Co., Ltd., in 2015, MSD K.K., Astellas Pharma Inc., Takeda Pharmaceutical Company, Ltd., Daiichi Sankyo Company, Ltd., and Otsuka Pharmaceutical Co., Ltd., in 2016, and MSD K.K., Shionogi & Co., Otsuka Pharmaceutical Co., Ltd., Takeda Pharmaceutical Company, Ltd., and Daiichi Sankyo Company, Ltd., in 2017. The companies associated with this funding were not involved in the manuscript preparation or the decision to publish the present case report. All other authors have no competing interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"363"}}