{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:34:48Z","timestamp":1787315688425,"version":"build-2736575974"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91670621"],"award-info":[{"award-number":["91670621"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12882-019-1284-3","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T02:13:33Z","timestamp":1554948813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis"],"prefix":"10.1186","volume":"20","author":[{"given":"Xishao","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6061-5697","authenticated-orcid":false,"given":"Jianghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"issue":"1","key":"1284_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1681\/ASN.2005050566","volume":"17","author":"M Rumpsfeld","year":"2006","unstructured":"Rumpsfeld M, McDonald SP, Johnson DW. Higher peritoneal transport status is associated with higher mortality and technique failure in the Australian and New Zealand peritoneal dialysis patient populations. J Am Soc Nephrol. 2006;17(1):271\u20138.","journal-title":"J Am Soc Nephrol"},{"key":"1284_CR2","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1681\/ASN.2006030194","volume":"17","author":"KS Brimble","year":"2006","unstructured":"Brimble KS, Walker M, Margetts PJ, et al. Meta-analysis: peritoneal membrane transport, mortality, and technique failure in peritoneal dialysis. J Am Soc Nephrol. 2006;17:2591\u20138.","journal-title":"J Am Soc Nephrol"},{"key":"1284_CR3","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1053\/j.ajkd.2014.06.030","volume":"64","author":"SJ Davies","year":"2014","unstructured":"Davies SJ. Peritoneal solute transport and inflammation. Am J Kidney Dis. 2014;64:978\u201386.","journal-title":"Am J Kidney Dis"},{"key":"1284_CR4","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1093\/ndt\/gfp670","volume":"25","author":"KH Oh","year":"2010","unstructured":"Oh KH, Jung JY, Yoon MO, et al. Intra-peritoneal interleukin-6 system is a potent determinant of the baseline peritoneal solute transport in incident peritoneal dialysis patients. Nephrol Dial Transplant. 2010;25:1639\u201346.","journal-title":"Nephrol Dial Transplant"},{"key":"1284_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-2369-15-8","volume":"15","author":"Y Cho","year":"2014","unstructured":"Cho Y, Johnson DW, Vesey DA, et al. Dialysate interleukin-6 predicts increasing peritoneal solute transport rate in incident peritoneal dialysis patients. BMC Nephrol. 2014;15:8.","journal-title":"BMC Nephrol"},{"key":"1284_CR6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/089686080602600109","volume":"26","author":"R Pecoits-Filho","year":"2006","unstructured":"Pecoits-Filho R, Carvalho MJ, Stenvinkel P, et al. Systemic and intraperitoneal interleukin-6 system during the first year of peritoneal dialysis. Perit Dial Int. 2006;26:53\u201363.","journal-title":"Perit Dial Int"},{"key":"1284_CR7","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1681\/ASN.2013030314","volume":"24","author":"M Lambie","year":"2013","unstructured":"Lambie M, Chess J, Donovan KL, et al. Independent effects of systemic and peritoneal inflammation on peritoneal dialysis survival. J Am Soc Nephrol. 2013;24:2071\u201380.","journal-title":"J Am Soc Nephrol"},{"key":"1284_CR8","doi-asserted-by":"publisher","first-page":"422","DOI":"10.3389\/fimmu.2015.00422","volume":"6","author":"E Venereau","year":"2015","unstructured":"Venereau E, Ceriotti C, Bianchi ME. DAMPs from cell death to new life. Front Immunol. 2015;6:422.","journal-title":"Front Immunol"},{"issue":"11","key":"1284_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s11882-018-0817-3","volume":"18","author":"S Patel","year":"2018","unstructured":"Patel S. Danger-associated molecular patterns (DAMPs): the derivatives and triggers of inflammation. Curr Allergy Asthma Rep. 2018;18(11):63.","journal-title":"Curr Allergy Asthma Rep"},{"key":"1284_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0005-2728(98)00161-3","volume":"1410","author":"JW Taanman","year":"1999","unstructured":"Taanman JW. The mitochondrial genome: structure, transcription, translation and replication. Biochim Biophys Acta. 1999;1410:103\u201323.","journal-title":"Biochim Biophys Acta"},{"key":"1284_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s00439-011-1057-y","volume":"131","author":"G Escames","year":"2012","unstructured":"Escames G, Lopez LC, Garcia JA, et al. Mitochondrial DNA and inflammatory diseases. Hum Genet. 2012;131:161\u201373.","journal-title":"Hum Genet"},{"key":"1284_CR12","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/SHK.0b013e3181cd8c08","volume":"34","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Itagaki K, Hauser CJ. Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase. Shock. 2010;34:55\u20139.","journal-title":"Shock"},{"key":"1284_CR13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/SLA.0b013e3182a4ea46","volume":"258","author":"JD Simmons","year":"2013","unstructured":"Simmons JD, Lee YL, Mulekar S, et al. Elevated levels of plasma mitochondrial DNA DAMPs are linked to clinical outcome in severely injured human subjects. Ann Surg. 2013;258:591\u20138.","journal-title":"Ann Surg"},{"key":"1284_CR14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072834","volume":"8","author":"X Gu","year":"2013","unstructured":"Gu X, Yao Y, Wu G, et al. The plasma mitochondrial DNA is an independent predictor for post-traumatic systemic inflammatory response syndrome. PLoS One. 2013;8:e72834.","journal-title":"PLoS One"},{"key":"1284_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1097\/SHK.0b013e318277109c","volume":"39","author":"LF Gentile","year":"2013","unstructured":"Gentile LF, Moldawer LL. Damps, Pamps, and the origins of sirs in bacterial Sepsis. Shock. 2013;39:113\u20134.","journal-title":"Shock"},{"key":"1284_CR16","doi-asserted-by":"publisher","first-page":"R234","DOI":"10.1186\/ar787","volume":"5","author":"S Hajizadeh","year":"2003","unstructured":"Hajizadeh S, DeGroot J, TeKoppele JM, et al. Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis. Arthritis Res Ther. 2003;5:R234\u201340.","journal-title":"Arthritis Res Ther"},{"key":"1284_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373\u201383.","journal-title":"J Chronic Dis"},{"key":"1284_CR18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/089686088700700306","volume":"7","author":"ZJ Twardowski","year":"1987","unstructured":"Twardowski ZJ, Nolph KD, Khanna R, et al. Peritoneal Equilibration Test. Periton Dialysis Int. 1987;7:138\u201347.","journal-title":"Periton Dialysis Int"},{"key":"1284_CR19","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1373\/49.5.719","volume":"49","author":"RW Chiu","year":"2003","unstructured":"Chiu RW, Chan LY, Lam NY, et al. Quantitative analysis of circulating mitochondrial DNA in plasma. Clin Chem. 2003;49:719\u201326.","journal-title":"Clin Chem"},{"key":"1284_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/SHK.0000000000000160","volume":"41","author":"TD Walko 3rd","year":"2014","unstructured":"Walko TD 3rd, Bola RA, Hong JD, et al. Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury. Shock. 2014;41:499\u2013503.","journal-title":"Shock"},{"key":"1284_CR21","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1089\/ars.2015.6407","volume":"23","author":"K Nakahira","year":"2015","unstructured":"Nakahira K, Hisata S, Choi AM. The roles of mitochondrial damage-associated molecular patterns in diseases. Antioxid Redox Signal. 2015;23:1329\u201350.","journal-title":"Antioxid Redox Signal"},{"key":"1284_CR22","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/embor.2011.157","volume":"12","author":"D Arnoult","year":"2011","unstructured":"Arnoult D, Soares F, Tattoli I, et al. Mitochondria in innate immunity. EMBO Rep. 2011;12:901\u201310.","journal-title":"EMBO Rep"},{"issue":"6","key":"1284_CR23","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nri.2017.21","volume":"17","author":"AP West","year":"2017","unstructured":"West AP, Shadel GS. Mitochondrial DNA in innate immune responses and inflammatory pathology. Nat Rev Immunol. 2017;17(6):363\u201375.","journal-title":"Nat Rev Immunol"},{"issue":"7285","key":"1284_CR24","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nature08780","volume":"464","author":"Q Zhang","year":"2010","unstructured":"Zhang Q, Raoof M, Chen Y, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104\u20137.","journal-title":"Nature"},{"key":"1284_CR25","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1681\/ASN.2015040376","volume":"27","author":"N Tsuji","year":"2016","unstructured":"Tsuji N, Tsuji T, Ohashi N, et al. Role of mitochondrial DNA in septic AKI via toll-like receptor 9. J Am Soc Nephrol. 2016;27:2009\u201320.","journal-title":"J Am Soc Nephrol"},{"key":"1284_CR26","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.jcrc.2013.05.006","volume":"28","author":"S Yamanouchi","year":"2013","unstructured":"Yamanouchi S, Kudo D, Yamada M, et al. Plasma mitochondrial DNA levels in patients with trauma and severe sepsis: time course and the association with clinical status. J Crit Care. 2013;28:1027\u201331.","journal-title":"J Crit Care"},{"key":"1284_CR27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1093\/qjmed\/hcp201","volume":"103","author":"CH Lu","year":"2010","unstructured":"Lu CH, Chang WN, Tsai NW, et al. The value of serial plasma nuclear and mitochondrial DNA levels in adult community-acquired bacterial meningitis. QJM. 2010;103:169\u201375.","journal-title":"QJM."},{"key":"1284_CR28","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1097\/SHK.0b013e318266a169","volume":"38","author":"MA Puskarich","year":"2012","unstructured":"Puskarich MA, Shapiro NI, Trzeciak S, et al. Plasma levels of mitochondrial DNA in patients presenting to the emergency department with sepsis. Shock. 2012;38:337\u201340.","journal-title":"Shock"},{"key":"1284_CR29","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1479-5876-10-130","volume":"10","author":"CT Kung","year":"2012","unstructured":"Kung CT, Hsiao SY, Tsai TC, et al. Plasma nuclear and mitochondrial DNA levels as predictors of outcome in severe sepsis patients in the emergency room. J Transl Med. 2012;10:130.","journal-title":"J Transl Med"},{"key":"1284_CR30","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ijcard.2012.04.047","volume":"158","author":"M Bliksoen","year":"2012","unstructured":"Bliksoen M, Mariero LH, Ohm IK, et al. Increased circulating mitochondrial DNA after myocardial infarction. Int J Cardiol. 2012;158:132\u20134.","journal-title":"Int J Cardiol"},{"issue":"7","key":"1284_CR31","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1016\/j.resuscitation.2012.03.032","volume":"83","author":"F Arnalich","year":"2012","unstructured":"Arnalich F, Codoceo R, Lopez-Collazo E, et al. Circulating cell-free mitochondrial DNA: a better early prognostic marker in patients with out-of-hospital cardiac arrest. Resuscitation. 2012;83(7):e162\u20133.","journal-title":"Resuscitation"},{"key":"1284_CR32","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1159\/000443442","volume":"41","author":"CC Szeto","year":"2016","unstructured":"Szeto CC, Lai KB, Chow KM, et al. Plasma mitochondrial DNA level is a prognostic marker in peritoneal Dialysis patients. Kidney Blood Press Res. 2016;41:402\u201312.","journal-title":"Kidney Blood Press Res"},{"key":"1284_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113179","volume":"9","author":"H Cao","year":"2014","unstructured":"Cao H, Ye H, Sun Z, et al. Circulatory mitochondrial DNA is a pro-inflammatory agent in maintenance hemodialysis patients. PLoS One. 2014;9:e113179.","journal-title":"PLoS One"},{"key":"1284_CR34","doi-asserted-by":"publisher","first-page":"909373","DOI":"10.1155\/2014\/909373","volume":"2014","author":"Y Cho","year":"2014","unstructured":"Cho Y, Hawley CM, Johnson DW. Clinical causes of inflammation in peritoneal dialysis patients. Int J Nephrol. 2014;2014:909373.","journal-title":"Int J Nephrol"},{"key":"1284_CR35","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1053\/j.ajkd.2014.02.025","volume":"64","author":"Y Cho","year":"2014","unstructured":"Cho Y, Johnson DW. Peritoneal dialysis-related peritonitis: towards improving evidence, practices, and outcomes. Am J Kidney Dis. 2014;64:278\u201389.","journal-title":"Am J Kidney Dis"},{"key":"1284_CR36","first-page":"20424","volume":"8","author":"L Zhou","year":"2015","unstructured":"Zhou L, Wen F, Chen G, et al. Cytokine profiles in peritoneal dialysis effluent predicts the peritoneal solute transport rate in continuous ambulatory peritoneal dialysis patients. Int J Clin Exp Med. 2015;8:20424\u201333.","journal-title":"Int J Clin Exp Med"},{"key":"1284_CR37","doi-asserted-by":"publisher","first-page":"912595","DOI":"10.1155\/2012\/912595","volume":"2012","author":"G Baroni","year":"2012","unstructured":"Baroni G, Schuinski A, de Moraes TP, et al. Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis. Mediat Inflamm. 2012;2012:912595.","journal-title":"Mediat Inflamm"},{"issue":"3","key":"1284_CR38","doi-asserted-by":"publisher","first-page":"e59989","DOI":"10.1371\/journal.pone.0059989","volume":"8","author":"S Sun","year":"2013","unstructured":"Sun S, Sursal T, Adibnia Y, et al. Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One. 2013;8(3):e59989.","journal-title":"PLoS One"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-019-1284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12882-019-1284-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-019-1284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T19:15:17Z","timestamp":1586459717000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-019-1284-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1284"],"URL":"https:\/\/doi.org\/10.1186\/s12882-019-1284-3","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]},"assertion":[{"value":"3 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"128"}}