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While most patients with AKI are admitted in conventional medical units, current available data are still obtained from studies designed for patients admitted in intensive care units (ICU). Our study aimed to elaborate and validate an in-hospital death prognosis score for AKI admitted in conventional medical care units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included two prospective cohorts of consecutive patients with AKI admitted between 2001 and 2004 (elaboration cohort (EC)) and between 2010 and 2014 (validation cohort (VC)). We developed a scoring system from clinical and biological parameters recorded at admission from the EC to predict in-hospital mortality. This score was then tested for validation in the VC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three-hundred and twenty-three and 534 patients were included in the EC and VC cohorts, respectively. The proportion of in-hospital death were 15.5% (EC) and 8.9% (VC), mainly due to sepsis. The parameters independently associated with the in-hospital death in the EC were Glasgow score, oxygen requirement, fluid overload,\u00a0blood diastolic pressure, multiple myeloma and prothrombin time<jats:italic>.<\/jats:italic>The in-hospital death prognosis score AUC was 0.845 +\/\u2212\u20090.297 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) after validation in the VC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our in-hospital death prognosis score is the first to be prospectively developed and validated for AKI admitted in a conventional medical care unit. Based on current parameters, easily collected at time of admission, this score could be a useful tool for physicians and nephrologists to determine the in-hospital death prognosis of this AKI population.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12882-019-1610-9","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T12:04:07Z","timestamp":1574337847000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Acute kidney injury in non-critical care setting: elaboration and validation of an in-hospital death prognosis score"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-8685","authenticated-orcid":false,"given":"Jamal","family":"Bamoulid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Philippot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Kazory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Yannaraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Crepin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9reng\u00e8re","family":"Vivet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nad\u00e8ge","family":"Devillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Roubiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bresson-Vautrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Chalopin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Courivaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Ducloux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"issue":"2","key":"1610_CR1","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.annfar.2004.11.017","volume":"24","author":"D Payen","year":"2005","unstructured":"Payen D, Berton C. 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In accordance with European and French legislation, \u201c(French translation) reference methodology MR-004 of the French National Agency regulating Data Protection (CNIL) covers the processing of personal data for purposes of study, evaluation or research that does not involve the individual. Specifically, these are studies that do not meet the definition of research involving the human person, particularly studies on the use of data\u201d (Deliberation n\u00b0 2018\u2013155 of May 3, 2018 published in the Official Journal of the French Republic n\u00b00160 of July 13, 2018, text n\u00b0 110).\u201d In accordance with the MR-004 of the French National Agency regulating Data Protection (CNIL), an administrative permission was required to access the raw data. Hence, there was no implication of any ethic comity to get permission to access the raw data. All patients participating in this study received written informed information and the opportunity to oppose the use of their data.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"419"}}