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Special subgroup analysis was directed towards the development and progression of peripheral vascular complications (PVC) (amputation, ischemic ulceration, lower extremity angioplasty\/ bypass surgery) after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 10-year patient survival was significantly higher in the SPKT group (SPKT: 82% versus KTA 40%;<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). KTA recipients had a higher prevalence of atherosclerotic risk factors, including coronary artery disease (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), higher serum triglyceride levels (<jats:italic>P<\/jats:italic>\u00a0=\u20090.049), higher systolic (<jats:italic>P<\/jats:italic>\u00a0=\u20090.03) and diastolic (<jats:italic>P<\/jats:italic>\u00a0=\u20090.02) blood pressure levels. The incidence of PVD before transplantation was comparable between both groups (<jats:italic>P<\/jats:italic>\u00a0=\u20090.114). Risk factor adjusted multivariate analysis revealed that patients with SPKT had a significant lower amount (32%) of PVCs (32 PVCs in 21 out of 101 SPKT;<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) when compared to the KTA patients who developed a significant increase in PVCs to 69% of cases (18 PVCs in 11 out of 26 KTA;<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001). In line mean values of HbA<jats:sub>1c<\/jats:sub>(<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) and serum triglycerides (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.01) were significantly lower in patients with SPKT &gt;\u20098\u2009years after transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SPKT favorably slows down development and progression of PVD by maintaining a superior metabolic vascular risk profile in patients with IDDM1.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12882-019-1649-7","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T14:03:00Z","timestamp":1575900180000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of simultaneous pancreas-kidney transplantation and kidney transplantation alone on the outcome of peripheral vascular diseases"],"prefix":"10.1186","volume":"20","author":[{"given":"Robert","family":"Sucher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rademacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Brunotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Alvanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Sucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Seehofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Michael","family":"Hau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"1649_CR1","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1016\/S0140-6736(09)60609-7","volume":"373","author":"SA White","year":"2009","unstructured":"White SA, Shaw JA, Sutherland D. 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Due to the retrospective design of the study and accordingly national guidelines, the local ethic committee confirmed, that informed consent was not necessary from participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"453"}}