{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:38:53Z","timestamp":1790249933100,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T00:00:00Z","timestamp":1585526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondazione Carispaq"},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","award":["not applicable"],"award-info":[{"award-number":["not applicable"]}],"id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human leukocyte antigen (HLA)-G is a non-classical HLA molecule with immunomodulant and immunosuppressive functions, involved in transplantation tolerance. HLA-G14bp ins\/del polymorphism in exon 8 has been associated with allograft rejection and kidney transplant outcome, with controversial results. We investigated associations of HLA-G14bp ins\/del polymorphism on onset of some of the main post-transplant risk factors, like excess body weight, lipid abnormalities, increased fasting plasma glucose. Polymorphisms of cytokines with both immunosuppressive and metabolic effects were also assessed for comparisons and associated analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study involved kidney transplant recipients (<jats:italic>n<\/jats:italic>\u2009=\u2009173) in which body mass index, cholesterol, triglycerides, fasting plasma glucose were registered in the first years after transplantation and analyzed in association with genotypes. Presence of hypertension and smoking habits, demographic, transplant-related and therapeutic data of patients were also recorded. Polymerase chain reaction, sequence-specific primer amplification and Taqman allelic discrimination techniques were used for genotyping of HLA-G14bp ins\/del, interleukin (IL)-10(\u22121082G\u2009&gt;\u2009A,-819\u2009T\u2009&gt;\u2009C,\u2013592A\u2009&gt;\u2009C), transforming growth factor-\u03b2(+\u2009869\u2009T\u2009&gt;\u2009C,+915C\u2009&gt;\u2009G), IL-6(\u2212174G\u2009&gt;\u2009C), tumor necrosis factor-\u03b1(\u2212308G\u2009&gt;\u2009A) and IL-18(\u2212137G\u2009&gt;\u2009C,-607C\u2009&gt;\u2009A). Effects of genotypes on clinical markers at each time point (pre-transplant and 1 to 5\u2009years after transplant) were analyzed using a repeated-measures general linear model analysis; adjustment for potential confounders was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results showed that HLA-G14bp ins\/ins was significantly associated with obesity, in particular after transplantation (3\u2009years,<jats:italic>p<\/jats:italic>\u2009=\u20090.002, OR\u2009=\u20094.48, 95% CI:1.76\u201311.41). Post-transplant body mass index was significantly increased in HLA-G14bp ins\/ins carriers (3 and 4\u2009years,<jats:italic>p<\/jats:italic>\u2009=\u20090.033 and<jats:italic>p<\/jats:italic>\u2009=\u20090.044); effects of HLA-G14bp genotypes on post-transplant BMI were confirmed by using repeated-measures analysis and after controlling for confounding variables. Cytokine genotypes did not associate with the examined factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study of transplanted patients allowed to evidence a potential relationship between post-transplant weight gain and HLA-G14bp ins\/del polymorphism, previously involved in rejection for its immunosuppressive\/tolerogenic activity. This novel association could widen the knowledge of the role and functions of HLA-G molecules in diseases and transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12882-020-01752-6","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T04:02:41Z","timestamp":1585540961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA-G14bp ins\/del polymorphism and post-transplant weight gain in kidney transplantation: potential implications beyond tolerance"],"prefix":"10.1186","volume":"21","author":[{"given":"Daniela","family":"Piancatelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Maccarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Colanardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Iesari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirino","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"1752_CR1","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11892-009-0047-0","volume":"9","author":"S Badiou","year":"2009","unstructured":"Badiou S, Cristol JP, Mourad G. Dyslipidemia following kidney transplantation: diagnosis and treatment. Curr Diab Rep. 2009;9:305\u201311.","journal-title":"Curr Diab Rep"},{"key":"1752_CR2","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1097\/TP.0b013e3182a688a4","volume":"97","author":"SP Curran","year":"2014","unstructured":"Curran SP, Famure O, Li Y, Kim SJ. Increased recipient body mass index is associated with acute rejection and other adverse outcomes after kidney transplantation. Transplantation. 2014;97:64\u201370.","journal-title":"Transplantation."},{"key":"1752_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/ndt\/16.1.14","volume":"16","author":"T Pischon","year":"2001","unstructured":"Pischon T, Sharma AM. Obesity as a risk factor in renal transplant patients. Nephrol Dial Transplant. 2001;16:14\u20137.","journal-title":"Nephrol Dial Transplant"},{"key":"1752_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrendo.2009.264","volume":"6","author":"A Iyer","year":"2010","unstructured":"Iyer A, Fairlie DP, Prins JB, Hammock BD, Brown L. Inflammatory lipid mediators in adipocyte function and obesity. Nat Rev Endocrinol. 2010;6:71\u201382.","journal-title":"Nat Rev Endocrinol"},{"key":"1752_CR5","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.humimm.2012.02.023","volume":"73","author":"S Ilavska","year":"2012","unstructured":"Ilavska S, Horvathova M, Szabov\u00e1 M, Nemess\u00e1nyi T, Jahnov\u00e1 E, Tulinsk\u00e1 J, et al. Association between the human immune response and body mass index. Hum Immunol. 2012;73:480\u20135.","journal-title":"Hum Immunol"},{"key":"1752_CR6","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1258\/ebm.2010.010227","volume":"235","author":"EA Karlsson","year":"2010","unstructured":"Karlsson EA, Beck MA. The burden of obesity on infectious disease. Exp Biol Med. 2010;235:1412\u201324.","journal-title":"Exp Biol Med"},{"key":"1752_CR7","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1111\/j.1398-9995.2007.01506.x","volume":"62","author":"LG Hersoug","year":"2007","unstructured":"Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007;62:1205\u201313.","journal-title":"Allergy."},{"key":"1752_CR8","first-page":"803429","volume":"2011","author":"J Bamoulid","year":"2011","unstructured":"Bamoulid J, Courivaud C, Deschamps M, Gaugler B, Tiberghien P, Chalopin JM, et al. The Interleukin-6 gene promoter polymorphism \u2212174 and atherosclerotic events in overweight transplanted patients. J Transp Secur. 2011;2011:803429.","journal-title":"J Transp Secur"},{"key":"1752_CR9","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.metabol.2006.12.015","volume":"56","author":"SR Thompson","year":"2007","unstructured":"Thompson SR, Sanders J, Stephens JW, Miller GJ, Humphries SE. A common interleukin 18 haplotype is associated with higher body mass index in subjects with diabetes and coronary heart disease. Metabolism. 2007;56:662\u20139.","journal-title":"Metabolism."},{"key":"1752_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1477-7827-10-31","volume":"10","author":"HL Kim","year":"2012","unstructured":"Kim HL, Cho SO, Kim SY, Kim SH, Chung WS, Chung SH. Association of Interleukin-18 gene polymorphism with body mass index in women. Reprod Biol Endocrinol. 2012;10:31\u20136.","journal-title":"Reprod Biol Endocrinol"},{"key":"1752_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00251-004-0673-2","volume":"56","author":"TV Hviid","year":"2004","unstructured":"Hviid TV, Rizzo R, Christiansen OB, Melchiorri L, Lindhard A, Baricordi OR. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. Immunogenetics. 2004;56:135\u201341.","journal-title":"Immunogenetics."},{"key":"1752_CR12","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1034\/j.1600-6143.2003.30103.x","volume":"3","author":"N Rouas-Freiss","year":"2003","unstructured":"Rouas-Freiss N, LeMaoult J, Moreau P, Dausset J, Carosella ED. HLA-G in transplantation: a relevant molecule for inhibition of graft rejection? Am J Transpl. 2003;3:11\u20136.","journal-title":"Am J Transpl"},{"key":"1752_CR13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1399-0039.2007.00961.x","volume":"71","author":"JC Crispim","year":"2008","unstructured":"Crispim JC, Mendes-Junior CT, Wastowski IJ, Costa R, Castelli EC, Saber LT, Donadi EA. Frequency of insertion\/deletion polymorphism in exon 8 of HLA-G and kidney allograft outcome. Tissue Antigens. 2008;71:35\u201341.","journal-title":"Tissue Antigens"},{"key":"1752_CR14","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.5301\/jn.5000252","volume":"26","author":"R Littera","year":"2013","unstructured":"Littera R, Piredda G, Pani A, Frongia M, Onano B, Michittu MB, et al. Role of human leukocyte antigen-G 14-base pair polymorphism in kidney transplantation outcomes. J Nephrol. 2013;26:1170\u20138.","journal-title":"J Nephrol"},{"key":"1752_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/tan.12210","volume":"82","author":"MK Misra","year":"2013","unstructured":"Misra MK, Prakash S, Kapoor R, Pandey SK, Sharma RK, Agrawal S. Association of HLA-G promoter and 14-Bp insertion-deletion variants with acute allograft rejection and end-stage renal disease. Tissue Antigens. 2013;82:317\u201326.","journal-title":"Tissue Antigens"},{"key":"1752_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.trim.2015.10.001","volume":"33","author":"Z Zilinska","year":"2015","unstructured":"Zilinska Z, Bandzuchova H, Chrastina M, Trebatick\u00fd B, Breza JS, Handzu\u0161ov\u00e1 M, et al. Expression of HLA-G transcripts in graft biopsy samples of renal transplant recipients. Transpl Immunol. 2015;33:159\u201365.","journal-title":"Transpl Immunol"},{"key":"1752_CR17","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1007\/s00251-005-0788-0","volume":"57","author":"R Rizzo","year":"2005","unstructured":"Rizzo R, Hviid TV, Stignani M, Balboni A, Grappa MT, Melchiorri L, et al. The HLA-G genotype is associated with IL-10 levels in activated PBMCs. Immunogenetics. 2005;57:172\u201381.","journal-title":"Immunogenetics."},{"key":"1752_CR18","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.humimm.2017.10.003","volume":"78","author":"S Waters","year":"2017","unstructured":"Waters S, Lee S, Affandi JS, Irish A, Price P. The effect of genetic variants affecting NK function on cardiovascular health and the burden of CMV. Hum Immunology. 2017;78:747\u201351.","journal-title":"Hum Immunology"},{"key":"1752_CR19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1034\/j.1399-0039.2002.600202.x","volume":"60","author":"TV Hviid","year":"2002","unstructured":"Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB. HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens. 2002;60:122\u201332.","journal-title":"Tissue Antigens"},{"key":"1752_CR20","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1111\/j.1600-6143.2004.00561.x","volume":"4","author":"J Mytilineos","year":"2004","unstructured":"Mytilineos J, Laux G, Opelz G. Relevance of IL10, TGFbeta1, TNFalpha, and IL4Ralpha gene polymorphisms in kidney transplantation: a collaborative transplant study report. Am J Transplant. 2004;4:1684\u201390.","journal-title":"Am J Transplant"},{"key":"1752_CR21","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/j.1755-0998.2010.02847.x","volume":"10","author":"L Excoffier","year":"2010","unstructured":"Excoffier L, Lischer HE. Arlequin suite Ver 3.5: a new series of programs to perform population genetics analyses under Linux and windows. Mol Ecol Resour. 2010;10:564\u20137.","journal-title":"Mol Ecol Resour"},{"key":"1752_CR22","first-page":"1","volume":"854","author":"Report of a Who Expert Committee","year":"1995","unstructured":"Report of a Who Expert Committee. Physical Status: The Use and Interpretation of Anthropometry. World Heal Organ Tech Rep Ser. 1995;854:1\u2013452.","journal-title":"World Heal Organ Tech Rep Ser"},{"key":"1752_CR23","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.annepidem.2013.12.003","volume":"24","author":"S Baldissera","year":"2014","unstructured":"Baldissera S, Ferrante G, Quarchioni E, Minardi V, Possenti V, Carrozzi G, et al. Field substitution of nonresponders can maintain sample size and structure without altering survey estimates-the experience of the Italian behavioral risk factors surveillance system (PASSI). Ann Epidemiol. 2014;24:241\u20135.","journal-title":"Ann Epidemiol"},{"key":"1752_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/ajg.2010.340","volume":"106","author":"A Fabris","year":"2011","unstructured":"Fabris A, Segat L, Catamo E, Morgutti M, Vendramin A, Crovella S. HLA-G 14 bp deletion\/insertion polymorphism in celiac disease. Am J Gastroenterol. 2011;106:139\u201344.","journal-title":"Am J Gastroenterol"},{"key":"1752_CR25","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1399-0039.2012.01862.x","volume":"79","author":"F Sizzano","year":"2012","unstructured":"Sizzano F, Testi M, Zito L, Crocchiolo R, Troiano M, Mazzi B, et al. Genotypes and haplotypes in the 3\u2032 Untranslated region of the HLA-G gene and their association with clinical outcome of hematopoietic stem cell transplantation for Beta-thalassemia. Tissue Antigens. 2012;79:326\u201332.","journal-title":"Tissue Antigens"},{"key":"1752_CR26","doi-asserted-by":"publisher","first-page":"448","DOI":"10.2174\/187152812803590037","volume":"11","author":"R Rizzo","year":"2012","unstructured":"Rizzo R, Bortolotti D, Baricordi OR, Fainardi E. New insights into HLA-G and inflammatory diseases, Inflamm. Allergy Drug Targets. 2012;11:448\u201363.","journal-title":"Allergy Drug Targets"},{"key":"1752_CR27","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1210\/jc.2009-2747","volume":"95","author":"A Solini","year":"2010","unstructured":"Solini A, Muscelli E, Stignani M, Santini E, Rossi C, et al. Soluble human leukocyte antigen-G expression and glucose tolerance in subjects with different degrees of adiposity. J Clin Endocrinol Metab. 2010;95:3342\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"1752_CR28","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jri.2016.11.005","volume":"119","author":"F Beneventi","year":"2017","unstructured":"Beneventi F, Locatelli E, De Amici M, Martinetti M, Spinillo A. Soluble HLA-G concentrations in obese women during pregnancy and in cord blood. J Reprod Immunol. 2017;119:31\u20137.","journal-title":"J Reprod Immunol"},{"key":"1752_CR29","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1016\/j.jcyt.2015.06.007","volume":"17","author":"A Poloni","year":"2015","unstructured":"Poloni A, Maurizi G, Ciarlantini M, Medici M, Mattiucci D, Mancini S, et al. Interaction between human mature adipocytes and lymphocytes induces T-cell proliferation. Cytotherapy. 2015;17:1292\u2013301.","journal-title":"Cytotherapy."},{"key":"1752_CR30","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1097\/TP.0b013e3181ce243f","volume":"89","author":"G La Manna","year":"2010","unstructured":"La Manna G, Cappuccilli ML, Cianciolo G, Conte D, Comai G, Carretta E, et al. Cardiovascular disease in kidney transplant recipients: the prognostic value of inflammatory cytokine genotypes. Transplantation. 2010;89:1001\u20138.","journal-title":"Transplantation."},{"key":"1752_CR31","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.2337\/diabetes.52.7.1872","volume":"52","author":"A Kubaszek","year":"2003","unstructured":"Kubaszek A, Pihlajamaki J, Komarovski V, Lindi V, Lindstr\u00f6m J, Eriksson J, et al. Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish diabetes prevention study. Diabetes. 2003;52:1872\u20136.","journal-title":"Diabetes."},{"key":"1752_CR32","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1210\/jc.2003-031101","volume":"89","author":"M Mohlig","year":"2004","unstructured":"Mohlig M, Boeing H, Spranger J, Osterhoff M, Kroke A, Fisher E, et al. Body mass index and C-174G Interleukin-6 promoter polymorphism interact in predicting type 2 diabetes. J Clin Endocrinol Metab. 2004;89:1885\u201390.","journal-title":"J Clin Endocrinol Metab"},{"key":"1752_CR33","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/oby.2006.3","volume":"14","author":"K Klipstein-Grobusch","year":"2006","unstructured":"Klipstein-Grobusch K, Mohlig M, Spranger J, Hoffmann K, Rodrigues FU, Sharma AM, et al. Interleukin-6 G.-174G>C Promoter Polymorphism Is Associated with Obesity in the Epic-Potsdam Study. Obesity. 2006;14:14\u20138.","journal-title":"Obesity"},{"key":"1752_CR34","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1161\/ATVBAHA.107.140566","volume":"27","author":"A Zirlik","year":"2007","unstructured":"Zirlik A, Bavendiek U, Libby P, MacFarlane L, Gerdes N, Jagielska J, et al. TRAF-1, \u22122, \u22123, \u22125, and \u22126 are induced in atherosclerotic plaques and differentially mediate Proinflammatory functions of CD40L in endothelial cells. Arter Thromb Vasc Biol. 2007;27:1101\u20137.","journal-title":"Arter Thromb Vasc Biol"},{"key":"1752_CR35","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1210\/jc.2002-021437","volume":"88","author":"K Esposito","year":"2003","unstructured":"Esposito K, Pontillo A, Giugliano F, Giugliano G, Marfella R, Nicoletti G, et al. Association of low Interleukin-10 levels with the metabolic syndrome in obese women. J Clin Endocrinol Metab. 2003;88:1055\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"1752_CR36","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.atherosclerosis.2009.06.004","volume":"207","author":"A Riikola","year":"2009","unstructured":"Riikola A, Sipila K, Kahonen M, Jula A, Nieminen MS, Moilanen L, et al. Interleukin-6 promoter polymorphism and cardiovascular risk factors: the health 2000 survey. Atherosclerosis. 2009;207:466\u201370.","journal-title":"Atherosclerosis."},{"key":"1752_CR37","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.metabol.2007.07.005","volume":"56","author":"E Goyenechea","year":"2007","unstructured":"Goyenechea E, Parra D, Martinez JA. Impact of Interleukin 6 -174G>C Polymorphism on Obesity-Related Metabolic Disorders in People with Excess in Body Weight. Metabolism. 2007;56:1643\u20138.","journal-title":"Metabolism."},{"key":"1752_CR38","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.104.519702","volume":"112","author":"L Tiret","year":"2005","unstructured":"Tiret L, Godefroy T, Lubos E, Nicaud V, Tregouet DA, Barbaux S, et al. Genetic analysis of the Interleukin-18 system highlights the role of the Interleukin-18 gene in cardiovascular disease. Circulation. 2005;112:643\u201350.","journal-title":"Circulation."},{"key":"1752_CR39","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1093\/eurheartj\/ehp316","volume":"30","author":"JA Hernesniemi","year":"2009","unstructured":"Hernesniemi JA, Karhunen PJ, Oksala N, K\u00e4h\u00f6nen M, Levula M, Rontu R, et al. Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki sudden death study. Eur Heart J. 2009;30:2939\u201346.","journal-title":"Eur Heart J"},{"key":"1752_CR40","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1530\/EJE-07-0463","volume":"157","author":"J Evans","year":"2007","unstructured":"Evans J, Collins M, Jennings C, van der Merwe L, S\u00f6derstr\u00f6m I, Olsson T, et al. The Association of Interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease. Eur J Endocrinol. 2007;157:633\u201340.","journal-title":"Eur J Endocrinol"},{"key":"1752_CR41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.atherosclerosis.2009.06.032","volume":"208","author":"M Heiskanen","year":"2010","unstructured":"Heiskanen M, Kahonen M, Hurme M, Lehtim\u00e4ki T, Mononen N, Juonala M, et al. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the cardiovascular risk in young Finns study. Atherosclerosis. 2010;208:190\u20136.","journal-title":"Atherosclerosis."},{"key":"1752_CR42","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00394-011-0264-6","volume":"51","author":"SW Barth","year":"2012","unstructured":"Barth SW, Koch TC, Watzl B, Dietrich H, Will F, Bub A. Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content. Eur J Nutr. 2012;51:841\u201350.","journal-title":"Eur J Nutr"},{"key":"1752_CR43","doi-asserted-by":"publisher","first-page":"7054","DOI":"10.4049\/jimmunol.0803054","volume":"183","author":"R Bahri","year":"2009","unstructured":"Bahri R, Naji A, Menier C, Charpentier B, Carosella ED, Rouas-Freiss N, et al. Dendritic cells secrete the immunosuppressive HLA-G molecule upon CTLA4-Ig treatment: implication in human renal transplant acceptance. J Immunol. 2009;183:7054\u201362.","journal-title":"J Immunol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-020-01752-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12882-020-01752-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-020-01752-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T01:30:27Z","timestamp":1722648627000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-020-01752-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,30]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1752"],"URL":"https:\/\/doi.org\/10.1186\/s12882-020-01752-6","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,30]]},"assertion":[{"value":"30 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A statement on ethics approval and consent is included in M<i>ethods<\/i> section. Written informed consent was obtained from all subjects and the study was approved by the local ethics committee of the Azienda Sanitaria Locale, ASL L\u2019Aquila, study n. 50\/2008. Blood samples were obtained via the Unit of \u201cGeneral Surgery and Transplantation\u201d of S. Salvatore Hospital of L\u2019Aquila; no organs\/tissues were obtained from prisoners.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"109"}}