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However, the opinions on relevant predictive risk factors remain inconclusive. This study aimed to provide a systematic review and meta-analysis to determine the predisposing factors for sepsis-associated AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic literature search was performed in the Medline, Embase, Cochrane Library, PubMed, and Web of Science, databases, with an end-date of 25th May 2019. Valid data were retrieved in compliance with specific inclusion and exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Forty-seven observational studies were included for analysis, achieving a cumulative patient number of 55,911. The highest incidence of AKI was caused by septic shock. Thirty-one potential risk factors were included in the meta-analysis. Analysis showed that 20 factors were statistically significant. The odds ratio (OR) and 95% confidence interval (CI), as well as the prevalence of the most frequently-seen predisposing factors for sepsis-associated AKI, were as follows: septic shock [2.88 (2.36\u20133.52), 60.47%], hypertension [1.43 (1.20\u20131.70), 38.39%], diabetes mellitus [1.59 (1.47\u20131.71), 27.57%], abdominal infection [1.44 (1.32\u20131.58), 30.87%], the administration of vasopressors [2.95 (1.67\u20135.22), 64.61%], the administration of vasoactive drugs [3.85 (1.89\u20137.87), 63.22%], mechanical ventilation [1.64 (1.24\u20132.16), 68.00%], positive results from blood culture [1.60 (1.35\u20131.89), 41.19%], and a history of smoking [1.60 (1.09\u20132.36), 43.09%]. Other risk factors included cardiovascular diseases, coronary artery diseases, liver diseases, unknown infections, the administration of diuretics and ACEI\/ARB, the infection caused by gram-negative bacteria, and organ transplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Risk factors of S-AKI arise from a wide range of sources, making it difficult to predict and prevent this condition. Comorbidities, and certain drugs, are the main risk factors for S-AKI. Our review can provide guidance on the application of interventions to reduce the risks associated with sepsis-associated acute kidney injury and can also be used to tailor patient-specific treatment plans and management strategies in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-020-01974-8","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T06:03:45Z","timestamp":1596175425000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":173,"title":["Rates, predictors, and mortality of sepsis-associated acute kidney injury: a systematic review and meta-analysis"],"prefix":"10.1186","volume":"21","author":[{"given":"Jiefeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-5479","authenticated-orcid":false,"given":"Lesan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"1974_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.semnephrol.2015.01.002","volume":"35","author":"R Alobaidi","year":"2015","unstructured":"Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM. 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