{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:30:54Z","timestamp":1794022254392,"version":"4.8.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Showa University"},{"name":"All Japan Labor Welfare Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post-Transplant erythrocytosis (PTE) has not been studied in large recent cohorts. In this study, we evaluated the incidence, risk factors, and outcome of PTE with current transplant practices using the present World Health Organization criteria to define erythrocytosis. We also tested the hypothesis that the risk of PTE is greater with higher-quality kidneys.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the Deceased Donor Study which is an ongoing, multicenter, observational study of deceased donors and their kidney recipients that were transplanted between 2010 and 2013 across 13 centers. Eryrthocytosis is defined by hemoglobin&gt;\u200916.5\u2009g\/dL in men and&gt;\u200916\u2009g\/dL in women. Kidney quality is measured by Kidney Donor Profile Index (KDPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1123 recipients qualified to be in this study, PTE was observed at a median of 18\u2009months in 75 (6.6%) recipients. Compared to recipients without PTE, those with PTE were younger [mean 48\u00b111 vs 54\u00b113\u2009years,<jats:italic>p<\/jats:italic>&lt;\u20090.001], more likely to have polycystic kidney disease [17% vs 6%,<jats:italic>p<\/jats:italic>&lt;\u20090.001], have received kidneys from younger donors [36 \u00b113 vs 41\u00b115\u2009years], and be on RAAS inhibitors [35% vs 22%,<jats:italic>p<\/jats:italic>&lt;\u20090.001]. Recipients with PTE were less likely to have received kidneys from donors with hypertension [16% vs 32%,<jats:italic>p<\/jats:italic>= 0.004], diabetes [1% vs 11%,<jats:italic>p<\/jats:italic>= 0.008], and cerebrovascular event (24% vs 36%,<jats:italic>p<\/jats:italic>= 0.036). Higher KDPI was associated with decreased PTE risk [HR 0.98 (95% CI: 0.97\u20130.99)]. Over 60\u2009months of follow-up, only 17 (36%) recipients had sustained PTE. There was no association between PTE and graft failure or mortality,<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of PTE was low in our study and PTE resolved in majority of patients. Lower KDPI increases risk of PTE. The underutilization of RAAS inhibitors in PTE patients raises the possibility of under-recognition of this phenomenon and should be explored in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12882-021-02231-2","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T12:12:36Z","timestamp":1610453556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation"],"prefix":"10.1186","volume":"22","author":[{"given":"Sami","family":"Alasfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac E.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry G.","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather R.","family":"Thiessen-Philbrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis L.","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schr\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangamani","family":"Muthukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubab F.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera N.","family":"Harhay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona D.","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enver","family":"Akalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Bromberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"issue":"5","key":"2231_CR1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/ki.1983.86","volume":"23","author":"CG Wickre","year":"1983","unstructured":"Wickre CG, Norman DJ, Bennison A, et al. 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The scientific review boards of these OPOs approved the study. The study was performed in accordance with the Declaration of Helsinki. Informed consent was obtained from all the patients. No organs\/tissues were procured from prisoners.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"S. Alasfar: Grant support from CareDx, Shire, and NIH.S.G. Mansour: supported by the American Heart Association (18CDA34110151) and Patterson Trust Fund.P.P. Reese: Epidemiology consulting from COHRDATA related to dialysis outcomes. Grant\/Research Support from Merck, CVS. Initiated grants from Merck to the University of Pennsylvania to support the THINKER (kidney), USHER (heart) and SHELTER (lung) trials of transplanting organs from donors with Hepatitis C into Hepatitis C negative recipients. Initiated grants from CVS to the University of Pennsylvania to support studies of medication adherence. Associate Editor, American Journal of Kidney Disease.E. Akalin. Grant support from CareDx and NIH.I.E. Hall: NIH grant support from NCATS (UL1TR002538 and KL2TR002539).M.D. Doshi: Salary support from NIDDK.S. Mohan: Grant\/Research support from NIH (NIDDK\/NIAID\/NIHMD\/NIBIB). Consulting fees from Angion Pharmaceuticals. Deputy Editor, Kidney International Reports.D.C. Brennan: Grant\/Research support to Johns Hopkins from CareDx, honoraria for speaking, consulting fees from Amplyx and CareDx.C.R. Parikh: Consulting Fee from Renalytix. Grant\/Research Support from National Institute of Diabetes and Digestion and Kidney Diseases, National Heart, Lung and Blood Institute. Data Safety and Monitoring Board of Genfit, Abbott.Rest of the authors does not have any competing interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26"}}