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There are few studies focusing on Pr-AKI at high altitude in the literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>to investigate the incidence, etiology, clinical features and maternal-fetal outcomes of Pr-AKI in women living at high altitude.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>6,512 pregnant women attending the Department of Obstetrics &amp; Gynecology at local hospital from January 2015 to December 2018 were screened for Pr-AKI. Patients with serum creatinine above normal range(&gt;\u200970umol\/L) then underwent assessment to confirm the diagnosis of Pr-AKI. AKI was diagnosed and staged based on Kidney Disease Improving Global Outcomes(KDIGO) guideline. Individuals meeting the Pr-AKI criteria were recruited. Their clinical data were recorded and retrospectively analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Pr-AKI was identified in 136\/6512(2.09\u2009%) patients. Hypertensive disorders of pregnancy(HDP) was the leading cause of Pr-AKI(35.3\u2009%). 4(2.9\u2009%) women died and the majority(86.1\u2009%) had recovered renal function before discharge. Fetal outcomes were confirmed in 109 deliveries with gestational age\u2009\u2265\u200920 weeks. Pre-term delivery occurred in 30(27.3\u2009%) cases and perinatal deaths in 17(15.5\u2009%). The rate of low birth weight infant(LBWI) and intrauterine growth restriction(IUGR) was 22.0 and 10.9\u2009% respectively. 16(14.5\u2009%) infants were admitted to NICU after birth. Patients with HDP had a higher cesarean rate(56.3\u2009%). More IUGR(25.0\u2009%) and LBWI(37.8\u2009%) were observed in their infants with a higher risk of admission to NICU(22.0\u2009%). High altitude might have an adverse impact on HDP-related Pr-AKI patients with earlier terminated pregnancy and more stillbirth\/neonatal death. Logistic regression models indicated that uncontrolled blood pressure, high altitude and advanced AKI were associated with adverse fetal outcomes in HDP-related Pr-AKI patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Pr-AKI was not rare in high-altitude regions and caused severe fetal morbidities and mortalities. Uncontrolled blood pressure, high altitude and advanced AKI were all risk factors for adverse fetal outcomes in Pr-AKI patients, especially for those with hypertensive disorders of pregnancy.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-021-02418-7","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:21:46Z","timestamp":1623248506000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pregnancy-related acute kidney injury at high altitude: a retrospective observational study in a single center"],"prefix":"10.1186","volume":"22","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"issue":"4","key":"2418_CR1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1053\/j.ackd.2017.05.008","volume":"24","author":"SA Silver","year":"2017","unstructured":"Silver SA, Siew ED. 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