{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:54:49Z","timestamp":1794243289807,"version":"4.9.0"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700617"],"award-info":[{"award-number":["81700617"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873609"],"award-info":[{"award-number":["81873609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Podocytic infolding glomerulopathy (PIG) is a rare pathological change which was characterized by the microspheres or microtubular structures in the thickened glomerular basement membrane (GBM). Only a few dozen cases have been reported worldwide so far. Here we present a case of PIG with systemic lupus erythematosus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>A 61-year-old Chinese female was diagnosed with systemic lupus erythematosus with clinical manifestations of proteinuria, pleural effusion, seroperitoneum, anemia, leukopenia, thrombocytopenia, antinuclear antibody positive, and hypocomplementemia. She also had benign ovarian tumor and\u00a0Epstein-Barr\u00a0virus infection. Renal biopsy immunofluorescent staining showed IgM and C3 were granularly deposited along the capillary wall instead of typical \u201cfull house\u201d features. Electron microscopy showed lots of microspheres structures were seen in the thickened GBM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present a case of PIG in a patient with systemic lupus erythematosus. The mechanisms of PIG are unknown, but may be associated with connective tissue disease and podocyte injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-021-02615-4","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T05:02:34Z","timestamp":1639198954000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A case of Podocytic Infolding Glomerulopathy with SLE and literature review"],"prefix":"10.1186","volume":"22","author":[{"given":"Xi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"2615_CR1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1186\/s12882-019-1478-8","volume":"20","author":"F W\u00f6stmann","year":"2019","unstructured":"W\u00f6stmann F, M\u00fcller R-U, G\u00f6bel H, et al. Case report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome. BMC Nephrol. 2019;20:326.","journal-title":"BMC Nephrol"},{"issue":"6","key":"2615_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s10157-008-0104-z","volume":"12","author":"K Joh","year":"2008","unstructured":"Joh K, Taguehi T, Shigematsu H, et al. Proposal of podocytic infolding glomerulopathy as a new diseaseentity:a review of 25 cases from nationwide research in Japan. Clin Exp Nephrol. 2008;12(6):421\u201331.","journal-title":"Clin Exp Nephrol"},{"issue":"5","key":"2615_CR3","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1007\/s10067-019-04504-6","volume":"38","author":"T Zhang","year":"2019","unstructured":"Zhang T, Sun W, Xue J, et al. Podocytic infolding glomerulopathy: two new cases with connective tissue disease and literature review. Clin Rheumatol. 2019;38(5):1521\u20138.","journal-title":"Clin Rheumatol"},{"issue":"4","key":"2615_CR4","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.semnephrol.2012.06.005","volume":"32","author":"DR Abrahamson","year":"2012","unstructured":"Abrahamson DR. Role of the podocyte (and glomerular endothelium) in building the GBM. Semin Nephrol. 2012;32(4):342\u20139.","journal-title":"Semin Nephrol"},{"key":"2615_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s10157-008-0095-9","volume":"12","author":"Y Fujigaki","year":"2008","unstructured":"Fujigaki Y, Muranaka Y, Sakakima M, et al. Analysis of intra-GBM microstructures in a SLE case with glomerulopathy associated with podocytic infolding. Clin Exp Nephrol. 2008;12:432\u20139.","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"2615_CR6","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12882-020-01809-6","volume":"21","author":"S Xiong","year":"2020","unstructured":"Xiong S, Shuai L, Li X, et al. Podocytic infolding in Schimke immuno-osseous dysplasia with novel SMARCAL1 mutations: a case report. BMC Nephrol. 2020;21(1):170.","journal-title":"BMC Nephrol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-021-02615-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-021-02615-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-021-02615-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T17:05:04Z","timestamp":1639242304000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-021-02615-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2615"],"URL":"https:\/\/doi.org\/10.1186\/s12882-021-02615-4","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"31 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent was obtained from the patient for the publication of the case report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"410"}}