{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:08:20Z","timestamp":1774382900970,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of changes in portal pressure before and after liver resection (defined as \u0394HVPG) on postoperative kidney function remains unknown. Therefore, we investigated the effect of \u0394HVPG on (i) the incidence of postoperative AKI and (ii) the renin-angiotensin system (RAAS) and sympathetic nervous system (SNS) activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 30 patients undergoing partial liver resection. Our primary outcome was postoperative AKI according to KDIGO criteria. For our secondary outcome we assessed the plasma renin, aldosterone, noradrenaline, adrenaline, dopamine and vasopressin concentrations prior and 2\u2009h after induction of anaesthesia, on the first and fifth postoperative day. HVPG was measured prior and immediately after liver resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      \u0394HVPG could be measured in 21 patients with 12 patients HVPG showing increases in HVPG (\u2206HVPG\u22651\u2009mmHg) while 9 patients remained stable. AKI developed in 7\/12 of patients with increasing HVPG, but only in 2\/9 of patients with stable \u0394HVPG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.302). Noradrenalin levels were significantly higher in patients with increasing \u0394HVPG than in patients with stable \u0394HVPG. (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). Biomarkers reflecting RAAS and SNS activity remained similar in patients with increasing vs. stable \u0394HVPG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with increased HVPG had higher postoperative creatinine concentrations, however, the incidence of AKI was similar between patients with increased versus stable HVPG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-021-02658-7","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T23:28:58Z","timestamp":1641598138000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury"],"prefix":"10.1186","volume":"23","author":[{"given":"Christian","family":"Reiterer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Taschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Luf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Hecking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dietmar","family":"Tamandl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Zotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Starlinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"2658_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1097\/ALN.0000000000000891","volume":"123","author":"F Kork","year":"2015","unstructured":"Kork F, et al. Minor postoperative increases of creatinine are associated with higher mortality and longer hospital length of stay in surgical patients. Anesthesiology. 2015;123:1301\u201311. https:\/\/doi.org\/10.1097\/ALN.0000000000000891.","journal-title":"Anesthesiology"},{"key":"2658_CR2","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/0002-9343(67)90247-1","volume":"43","author":"E Schroeder","year":"1967","unstructured":"Schroeder E, Shear L, Sancetta S, Gabuzda G. Renal failure in patients with cirrhosis of the liver. Am J Med. 1967;43:887\u201396. https:\/\/doi.org\/10.1016\/0002-9343(67)90247-1.","journal-title":"Am J Med"},{"key":"2658_CR3","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1111\/j.1872-034X.2007.00148.x","volume":"37","author":"WW Lautt","year":"2007","unstructured":"Lautt WW. Regulatory processes interacting to maintain hepatic blood flow constancy: vascular compliance, hepatic arterial buffer response, hepatorenal reflex, liver regeneration, escape from vasoconstriction. Hepatol Res. 2007;37:891\u2013903 https:\/\/doi.org\/10.1111\/j.1872-034X.2007.00148.x.","journal-title":"Hepatol Res"},{"key":"2658_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1159\/000142939","volume":"109","author":"R Moreau","year":"2008","unstructured":"Moreau R, Lebrec D. Acute kidney injury: new concepts - hepatorenal syndrome: the role of vasopressors. Nephron \u2013 Physiol. 2008;109:73\u20139. https:\/\/doi.org\/10.1159\/000142939.","journal-title":"Nephron \u2013 Physiol"},{"key":"2658_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1046\/j.1469-7580.1998.19240507.x","volume":"192","author":"E Morsiani","year":"1998","unstructured":"Morsiani E, Aleotti A, Ricci D. 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