{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:00:05Z","timestamp":1789243205703,"version":"build-2803163510"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T00:00:00Z","timestamp":1672444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017160","name":"Beni Suef University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017160","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is a major risk factor for contrast induced acute kidney injury (CI-AKI) in chronic coronary syndrome (CCS) patients undergoing coronary catheterization. We aimed to evaluate the efficacy of phentolamine in prevention of CI-AKI in CKD and CCS patients undergoing percutaneous coronary catheterization for diagnostic angiography \u00b1 stenting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants with CKD and CCS planned for percutaneous coronary catheterization were included, while participants with normal kidney functions were excluded. A consecutive sample of 107 participants (mean age 58.62\u2009\u00b1\u20098.96\u2009years, 64.5% males) was selected, underwent diagnostic coronary angiography or percutaneous coronary intervention, and received either conventional CI-AKI prevention strategy (group 1) or periprocedural phentolamine and conventional CI-AKI prevention strategy (group 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The percentages of study participants who had CI-AKI were 82.9% for group 1 and 17.1% for group 2, respectively. The incidence rate of CI-AKI was significantly lower in group 2 versus group 1 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.001). The urine output (ml\/kg) and the urine output (ml\/hour) within 72\u2009hours post procedure was significantly higher in group 2 versus group 1 (t(105)\u2009=\u2009\u2212\u20090.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009\u00a00.001, t(105)\u2009=\u2009\u2212\u200952.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively), the peak change in serum creatinine and the percentage of change relative to the baseline serum creatinine at 72\u2009hours post procedure was significantly lower in group 2 versus group 1 (t(102)\u2009=\u20090.2, p 0.018, t(102)\u2009=\u200923.54,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively), and the incidence rate of major adverse cardiac and cerebrovascular events within 90\u2009days post procedure was significantly lower in group 2 versus group 1 (t(102)\u2009=\u20091.168,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), respectively. There was a statistically significant association of periprocedural phentolamine infusion with prevention of CI-AKI (OR\u2009=\u20090.041, 95% CI 0.0149\u20130.1128,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study highlights the potential role of phentolamine for protection of the kidney in CKD patients planned for coronary catheterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Pan African Clinical Trial Registry Number: PACTR202209493847741.<\/jats:p>\n                    <jats:p>Date of Trial Registration: 22\/09\/2022.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-022-03050-9","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T19:02:38Z","timestamp":1672426958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of periprocedural phentolamine infusion with favorable outcome in patients with chronic kidney disease and chronic coronary syndrome undergoing coronary catheterization: a prospective randomized controlled pilot study"],"prefix":"10.1186","volume":"23","author":[{"given":"Mohamed abo","family":"Hamila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmy","family":"El Ghawaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Gabr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,31]]},"reference":[{"issue":"Suppl 2","key":"3050_CR1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1007\/s00270-005-0196-8","volume":"28","author":"P Parfrey","year":"2005","unstructured":"Parfrey P. 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