{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:27:44Z","timestamp":1754195264010},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Sarcoidosis affects multiple organs and exhibits diverse clinical manifestations. Although tubulointerstitial nephritis is a known feature of renal involvement, necrotizing vasculitis is rare. Furthermore, prostate involvement with urinary retention is unusual in patients with sarcoidosis. Here, we report a case of systemic sarcoidosis with a rare combination of manifestations and different acute kidney injuries.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 66-year-old man developed sudden urinary retention and fever. He was diagnosed with prostatitis and admitted to our hospital. An indwelling urethral catheter was inserted, and antimicrobial therapy was initiated; however, the prostatitis was refractory. Computed tomography revealed enlarged mediastinal lymph nodes. Analysis of transbronchoscopic lymph node and prostate biopsies showed epithelioid cell granulomas, suggesting systemic sarcoidosis. During the clinical course, the serum creatinine level rapidly increased to 2.36\u00a0mg\/dL without oliguria. A kidney biopsy revealed tubulointerstitial injury with moderate lymphohistiocytic infiltration and small-vessel vasculitis in the interstitium. Following oral administration of 60\u00a0mg\/day prednisolone, the patient\u2019s renal function immediately improved, and urinary retention did not recur.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>To the best of our knowledge, this is the first reported case of sarcoidosis with two unusual complications. Given its clinical course and pathology, this case is clinically valuable.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-023-03430-9","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:02:31Z","timestamp":1702476151000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic sarcoidosis presenting as a rare combination of interstitial nephritis with necrotizing vasculitis and urinary retention due to prostate involvement: a case report"],"prefix":"10.1186","volume":"24","author":[{"given":"Arata","family":"Osanami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Sakurada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Shindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Furuhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"3430_CR1","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1164\/ajrccm.164.10.2104046","volume":"164","author":"RP Baughman","year":"2001","unstructured":"Baughman RP, Teirstein AS, Judson MA, Rossman MD, Yeager H Jr, Bresnitz EA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885\u20139.","journal-title":"Am J Respir Crit Care Med"},{"key":"3430_CR2","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1001\/jama.2011.10","volume":"305","author":"MC Iannuzzi","year":"2011","unstructured":"Iannuzzi MC, Fontana JR. Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. JAMA. 2011;305:391\u20139.","journal-title":"JAMA"},{"key":"3430_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1097\/MAJ.0b013e31811eba71","volume":"335","author":"SK Mulpuru","year":"2008","unstructured":"Mulpuru SK, Gujja K, Pai VM, Chen CY, Levey RL. A rare and unusual cause of PSA (prostate-specific antigen) elevation: sarcoidosis of the prostate. Am J Med Sci. 2008;335:246\u20138.","journal-title":"Am J Med Sci"},{"key":"3430_CR4","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1093\/ndt\/gft442","volume":"29","author":"I Hilderson","year":"2014","unstructured":"Hilderson I, Van Laecke S, Wauters A, Donck J. Treatment of renal sarcoidosis: is there a guideline? Overview of the different treatment options. Nephrol Dial Transplant. 2014;29:1841\u20137.","journal-title":"Nephrol Dial Transplant"},{"key":"3430_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s40620-022-01369-y","volume":"36","author":"M Calatroni","year":"2023","unstructured":"Calatroni M, Moroni G, Reggiani F, Ponticelli C. Renal sarcoidosis. J Nephrol. 2023;36:5\u201315.","journal-title":"J Nephrol"},{"key":"3430_CR6","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/ndt\/gfac219","volume":"38","author":"S Mehta","year":"2023","unstructured":"Mehta S, Lightle A, Judson MA. Renal sarcoidosis. Nephrol Dial Transplant. 2023;38:803\u201310.","journal-title":"Nephrol Dial Transplant"},{"key":"3430_CR7","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1053\/j.ajkd.2011.09.025","volume":"59","author":"V Agrawal","year":"2012","unstructured":"Agrawal V, Crisi GM, D\u2019Agati VD, Freda BJ. Renal sarcoidosis presenting as acute kidney injury with granulomatous interstitial nephritis and vasculitis. Am J Kidney Dis. 2012;59:303\u20138.","journal-title":"Am J Kidney Dis"},{"key":"3430_CR8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s13256-015-0764-8","volume":"9","author":"N Maroz","year":"2015","unstructured":"Maroz N, Field H. Necrotizing crescentic glomerulonephritis related to sarcoidosis: a case report. J Med Case Rep. 2015;9:282.","journal-title":"J Med Case Rep"},{"key":"3430_CR9","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.4103\/1319-2442.215120","volume":"28","author":"A Harzallah","year":"2017","unstructured":"Harzallah A, Kaaroud H, Boubaker K, Barbouch S, Goucha R, Hamida FB, et al. Acute kidney injury with granulomatous interstitial nephritis and vasculitis revealing sarcoidosis. Saudi J Kidney Dis Transpl. 2017;28:1157\u201361.","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"3430_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1159\/000509590","volume":"10","author":"Y Kamata","year":"2020","unstructured":"Kamata Y, Sato H, Sugiura A, Miyata M, Kisu K, Azuma A. A case demonstrating the pathological relationship between granulomatous vasculitis and glomerular lesion in renal sarcoidosis. Case Rep Nephrol Dial. 2020;10:109\u201316.","journal-title":"Case Rep Nephrol Dial"},{"key":"3430_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65:1\u201311.","journal-title":"Arthritis Rheum"},{"key":"3430_CR12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/RHU.0000000000001839","volume":"28","author":"BA Kimbrough","year":"2022","unstructured":"Kimbrough BA, Warrington KJ, Langenfeld HE, Crowson CS, Carmona EM, Virata AR, et al. Vasculitis in patients with sarcoidosis: A single-institution case series of 17 patients. J Clin Rheumatol. 2022;28:217\u201322.","journal-title":"J Clin Rheumatol"},{"key":"3430_CR13","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1053\/sarh.2000.8364","volume":"30","author":"SR Fernandes","year":"2000","unstructured":"Fernandes SR, Singsen BH, Hoffman GS. Sarcoidosis and systemic vasculitis. Semin Arthritis Rheum. 2000;30:33\u201346.","journal-title":"Semin Arthritis Rheum"},{"key":"3430_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1750-1172-8-65","volume":"8","author":"T Stehl\u00e9","year":"2013","unstructured":"Stehl\u00e9 T, Joly D, Vanhille P, Boffa JJ, R\u00e9my P, Mesnard L, Hoffmann M, et al. Clinicopathological study of glomerular diseases associated with sarcoidosis: a multicenter study. Orphanet J Rare Dis. 2013;8:65.","journal-title":"Orphanet J Rare Dis"},{"key":"3430_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1136\/jcp.2006.039222","volume":"60","author":"B Furusato","year":"2007","unstructured":"Furusato B, Koff S, McLeod DG, Sesterhenn IA. Sarcoidosis of the prostate. J Clin Pathol. 2007;60:325\u20136.","journal-title":"J Clin Pathol"},{"key":"3430_CR16","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.juro.2013.05.017","volume":"190","author":"MJ Maurice","year":"2013","unstructured":"Maurice MJ, Zhu H. Sarcoidosis of the prostate. J Urol. 2013;190:711\u20132.","journal-title":"J Urol"},{"key":"3430_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/10790268.1996.11719434","volume":"19","author":"KJ Fitzpatrick","year":"1996","unstructured":"Fitzpatrick KJ, Chancellor MB, Rivas DA, Kumon H, Mandel S, Manon-Espaillat R. Urologic manifestation of spinal cord sarcoidosis. J Spinal Cord Med. 1996;19:201\u20133.","journal-title":"J Spinal Cord Med"},{"key":"3430_CR18","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0022-5347(05)66561-5","volume":"165","author":"IY Kim","year":"2001","unstructured":"Kim IY, Elliott DS, Husmann DA, Boone TB. An unusual presenting symptom of sarcoidosis: neurogenic bladder dysfunction. J Urol. 2001;165:903\u20134.","journal-title":"J Urol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-023-03430-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-023-03430-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-023-03430-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T14:04:44Z","timestamp":1702476284000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-023-03430-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["3430"],"URL":"https:\/\/doi.org\/10.1186\/s12882-023-03430-9","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was not part of a research study, and therefore, ethical approval was not sought.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"370"}}