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Early childhood insults such as birth asphyxia could be risk factors for chronic kidney disease in later life. Our study aimed to assess renal function among children aged two to four years, born to women with obstructed labour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We followed up 144 children aged two to four years, born to women with obstructed labor at Mbale regional referral hospital in Eastern Uganda. We used serum creatinine to calculate estimated glomerular filtration rate (eGFR) using the Schwartz formula. We defined decreased renal function as eGFR less than 90\u00a0ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the children was 2.8 years, standard deviation (SD) of 0.4 years. Majority of the children were male (96\/144: 66.7%). The mean umbilical lactate level at birth among the study participants was 8.9 mmol\/L with a standard deviation (SD) of 5.0. eGFR of the children ranged from 55 to 163\u00a0ml\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , mean 85.8\u2009\u00b1\u2009SD 15.9. Nearly one third of the children (45\/144) had normal eGFR (&gt;\u200990\u00a0ml\/Min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      ), two thirds (97\/144) had a mild decrease of eGFR (60\u201389\u00a0ml\/Min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      ), and only two children had a moderate decrease of eGFR (&lt;\u200960\u00a0ml\/Min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      ). Overall incidence of reduced eGFR was 68.8% [(99\/144): 95% CI (60.6 to 75.9)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed a high incidence of reduced renal function among children born to women with obstructed labour. We recommend routine follow up of children born to women with obstructed labour and add our voices to those calling for improved intra-partum and peripartum care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-024-03552-8","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:02:16Z","timestamp":1711598536000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study"],"prefix":"10.1186","volume":"25","author":[{"given":"David","family":"Mukunya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith","family":"Oguttu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendah","family":"Nambozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritah","family":"Nantale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian Tonny","family":"Makoko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Napyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Tumuhamye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Wani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prossy","family":"Auma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ketty","family":"Atim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doreck","family":"Nahurira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dedan","family":"Okello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Wamulugwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Ssegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Wandabwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kiguli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Chebet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton W.","family":"Musaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"issue":"10225","key":"3552_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"B Bikbov","year":"2020","unstructured":"Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, et al. 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Administrative clearance was obtained from the Mbale regional referral hospital Research and Ethics Committee (MRRH-REC IN-COM 00\/2018). Written informed consent was obtained from each of the participants before enrolment. All methods were carried out in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"116"}}