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Lipps Postdoctoral Research Fellowship Program"},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"crossref","award":["R01 HL146588"],"award-info":[{"award-number":["R01 HL146588"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015216","name":"Vanderbilt O\u2019Brien Kidney Center","doi-asserted-by":"publisher","award":["P30-DK114809"],"award-info":[{"award-number":["P30-DK114809"]}],"id":[{"id":"10.13039\/100015216","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015216","name":"Vanderbilt O\u2019Brien Kidney Center","doi-asserted-by":"publisher","award":["P30-DK114809"],"award-info":[{"award-number":["P30-DK114809"]}],"id":[{"id":"10.13039\/100015216","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Acute kidney injury (AKI) is associated with increased risk of heart failure (HF). Determining the type of HF experienced by AKI survivors (heart failure with preserved or reduced ejection fraction, HFpEF or HFrEF) could suggest potential mechanisms underlying the association and opportunities for improving post-AKI care.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective study of adults within the Vanderbilt University health system with a diagnosis of HF, we tested whether AKI events in the two years preceding incident HF associated more with HFpEF or HFrEF while controlling for known predictors. HF outcomes were defined by administrative codes and classified as HFpEF or HFrEF by echocardiogram data. We used multivariable logistic regression models to estimate the effects of AKI on the odds of incident HFpEF versus HFrEF.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AKI (all stages) trended towards a preferential association with HFpEF in adjusted analyses (adjusted OR 0.80, 95% CI 0.63 \u2013 1.01). Stage 1 AKI was associated with higher odds of HFpEF that was statistically significant (adjusted OR 0.62, 95% CI 0.43 \u2013 0.88), whereas stages 2\u20133 AKI showed a trend toward HFrEF that did not reach statistical significance (adjusted OR 1.11, 95% CI 0.76 \u2013 1.63).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>AKI as a binary outcome trended towards a preferential association with HFpEF. Stage 1 AKI was associated with higher odds of HFpEF, whereas stage 2\u20133 trended towards an association with HFrEF that did not meet statistical significance. Different mechanisms may predominate in incident HF following mild versus more severe AKI. Close follow-up with particular attention to volume status and cardiac function after discharge is warranted after even mild AKI.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-024-03602-1","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T06:01:57Z","timestamp":1715925717000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Heart failure subtype after acute kidney injury"],"prefix":"10.1186","volume":"25","author":[{"given":"Bethany C.","family":"Birkelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Brittain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Guide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Greevy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Matheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Annis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Faubel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward D.","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"issue":"17","key":"3602_CR1","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","volume":"118","author":"G Savarese","year":"2023","unstructured":"Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS. 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Informed consent was not required due to the use of de-identified data, which is considered non-human subjects research.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"EDS reports receiving personal fees for serving on the editorial board for the Clinical Journal of the American Society of nephrology, royalties as an author for UpToDate, and an agreement to serve on a DSMB study for Novartis.\u00a0MEM reports the following: Employer: Department of Veterans Affairs; Vanderbilt University Medical Center; Consultancy: NIH-VA-DoD Pain Management Grant Consortium (PMC3); Food and Drug Administration (FDA); and Advisory or Leadership Role: SMRB Study Section, VA HSR&D, Informatics & Methods Section; Steering Committee\u2014Indianapolis VA HSR&D COIN Center; Steering Committee\u2014VA HSR&D VIREC; Steering Committee\u2014Salt Lake City VA HSR&D COIN Center; VA ORD Million Veterans Program Executive Steering Committee. SF reports receiving consulting fees from SeaStar Medical.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"167"}}