{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:01:11Z","timestamp":1753520471791},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Hypercalcaemia is a common manifestation of sarcoidosis but is sparingly described in gastrointestinal stromal tumours (GISTs). We describe a case of acute kidney injury and hypercalcemia resulting from simultaneous diagnosis of GIST and sarcoidosis, the presentation of which has not yet been reported.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case Presentation<\/jats:title>\n                <jats:p>A 61-year-old male presented with acute kidney injury and hypercalcemia, with elevated 1,25-dihydroxyvitamin D levels. Investigations demonstrated a large gastric antral mass which was resected and proven to be GIST. Histopathology of incidentally found liver nodules revealed non-necrotising epithelioid granulomas consistent with concomitant sarcoidosis. The hypercalcemia was successfully treated with bisphosphonate therapy, resection of the GIST and a four month course of corticosteroids, which was truncated due to a mycobacterial infection.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our case report is the first to describe hypercalcemia due to GIST and biopsy-proven sarcoidosis, thereby raising the possibility of a common pathophysiological pathway relating the two entities. We review the literature describing the mechanisms of hypercalcaemia in GIST and the association between GIST and sarcoidosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-024-03655-2","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T12:01:33Z","timestamp":1721390493000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypercalcaemia in gastrointestinal stromal tumour and sarcoidosis: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Babitha","family":"Selvananthan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"issue":"11","key":"3655_CR1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.4103\/1947-2714.170600","volume":"7","author":"AE Mirrakhimov","year":"2015","unstructured":"Mirrakhimov AE. Hypercalcemia of Malignancy: an update on Pathogenesis and Management. N Am J Med Sci. 2015;7(11):483\u201393.","journal-title":"N Am J Med Sci"},{"key":"3655_CR2","doi-asserted-by":"crossref","unstructured":"Betlachin A, Kim SSR, Oxman R. MON-LB69 calcitriol-mediated hypercalcemia in a patient with metastatic gastrointestinal stromal tumor. J Endocr Soc. 2020;4 Suppl 1.","DOI":"10.1210\/jendso\/bvaa046.2271"},{"key":"3655_CR3","doi-asserted-by":"publisher","unstructured":"Barbaryan A, Bailuc S, Poddutoori P, Richardson A, Mirrakhimov AE. Gastrointestinal Stromal Tumor Induced Hypercalcemia. Case Reports in Oncological Medicine. 2017; https:\/\/doi.org\/10.1155\/2017\/4972017.","DOI":"10.1155\/2017\/4972017"},{"key":"3655_CR4","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1186\/s12885-015-1823-7","volume":"15","author":"K Hygum","year":"2015","unstructured":"Hygum K, Wulff CN, Harsl\u00f8f T, Boysen AK, Rossen PB, Langdahl BL, et al. 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The opportunity to read the manuscript was offered to the patient. A written informed consent form has been completed to publish the article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"229"}}