{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:45:55Z","timestamp":1779158755448,"version":"3.51.4"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Membranous nephropathy (MN) is a common type of nephrotic syndrome (NS) in adults, accounting for about 20\u201330% of cases. Although secondary to specific factors, the coexistence of MN and mantle cell lymphoma (MCL) has been scarcely reported in clinical literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 59-year-old Chinese male was admitted to the hospital with a generalized pruritic rash with bilateral lower extremity edema, which did not improve significantly after symptomatic treatment. He had undergone renal biopsy, and the diagnosis was thought to be secondary MN (SMN), therefore, we did a lymph node biopsy on the patient and found that MN was complicated with MCL. Soon after, the patient was admitted to the hematology department for a BR chemotherapy regimen (composed of bendamustine 90 mg\/m<jats:sup>2<\/jats:sup> BSA (body surface area), rituximab 375 mg\/m<jats:sup>2<\/jats:sup> BSA and dexamethasone 5\u00a0mg), and during the post-treatment follow-up, both his symptoms and renal function improved.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The mechanism underlying the combination of SMN and MCL remains elusive and exceedingly rare, consequently often overlooked in clinical practice. This case serves to offer valuable clinical insights for diagnosis and treatment, while emphasizing the pivotal role of renal pathology in clinical assessment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-024-03665-0","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T09:02:37Z","timestamp":1721034157000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnosis and treatment of secondary nephrotic syndrome with rash as the first symptom: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Bowen","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"issue":"4","key":"3665_CR1","first-page":"185","volume":"29","author":"G Geropoulos","year":"2020","unstructured":"Geropoulos G, Psarras K, Vlachaki E, Kakos C, Vetsiou E, Vamvakis K, Sousos N, Mpouras V, Symeonidis N, Pavlidis ET, et al. Cutaneous manifestations of mantle cell lymphoma: an extensive literature review. Acta Dermatovenerol Alp Pannonica Adriat. 2020;29(4):185\u201391.","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"issue":"2","key":"3665_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s13730-015-0173-2","volume":"4","author":"A Ishiwatari","year":"2015","unstructured":"Ishiwatari A, Hasegawa J, Hoshino Y, Kaga T, Abe Y, Wakai S. Simultaneous nephrotic syndrome and hepatitis in secondary syphilis: case report and review of the literature. CEN Case Rep. 2015;4(2):223\u20137.","journal-title":"CEN Case Rep"},{"key":"3665_CR3","first-page":"1","volume":"42","author":"A Kumar","year":"2022","unstructured":"Kumar A, Eyre TA, Lewis KL, Thompson MC, Cheah CY. New directions for Mantle Cell Lymphoma in 2022. 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Kidney Int Rep. 2022;7(3):568\u201379.","journal-title":"Kidney Int Rep"},{"issue":"06","key":"3665_CR6","first-page":"76","volume":"30","author":"F Liu","year":"2018","unstructured":"Liu F, Liu Y, Wang Y, Shen J. The efficacy and safety of bendamustine combined with rituximab and rituximab chemotherapy in the treatment of indolent non-hodgkin\u2019s lymphoma or mantle cell lymphoma. A meta analysis. Strait Pharm J. 2018;30(06):76\u201380.","journal-title":"Strait Pharm J"},{"issue":"04","key":"3665_CR7","first-page":"451","volume":"14","author":"D Cai","year":"2019","unstructured":"Cai D, Sun L. Feasibility study on bentamustine combined with rituximab in the treatment of mantle cell lymphoma. J Chengdu Med Coll. 2019;14(04):451\u20133.","journal-title":"J Chengdu Med Coll"},{"issue":"12","key":"3665_CR8","first-page":"1530","volume":"44","author":"Z Wan","year":"2023","unstructured":"Wan Z, Wang R, Li C. Diagnostic value and efficacy assessment of anti-phospholipase A2 receptor antibodies in membranous nephropathy. Int J Lab Med. 2023;44(12):1530\u20133.","journal-title":"Int J Lab Med"},{"issue":"2","key":"3665_CR9","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1681\/ASN.2020071082","volume":"32","author":"S Sethi","year":"2021","unstructured":"Sethi S. New \u2018Antigens\u2019 in Membranous Nephropathy. J Am Soc Nephrol. 2021;32(2):268\u201378.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"3665_CR10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/s13730-018-0336-z","volume":"7","author":"S Shimada","year":"2018","unstructured":"Shimada S, Nakamichi T, Yamada G, Narumi K, Usubuchi H, Yamamoto T, Ichikawa S, Fukuhara N, Miyazaki M, Harigae H, et al. Concurrent isolated IgG2-positive membranous nephropathy and malignant B-cell lymphoma. 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A copy of the written consent is available for review by the editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"225"}}