{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T05:48:39Z","timestamp":1793684919578,"version":"4.5.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Moscow Healthcare Department","award":["2412-66"],"award-info":[{"award-number":["2412-66"]}]},{"name":"Moscow Healthcare Department","award":["2412-66"],"award-info":[{"award-number":["2412-66"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Kidney transplantation is the optimal treatment modality for patients with end-stage chronic kidney disease. The long-term mortality of kidney recipients is 48\u201382% lower than that of patients on the waiting list. However, the risk of developing malignancies in these patients is twice as high as in the healthy population. Specifically, the incidence of renal cell carcinoma (RCC) in transplant recipients is 10\u201330 times higher than in non-transplanted patients. The reason for the increased risk is poorly understood, but is most likely related to continuous immunosuppressive therapy. The problem of kidney graft neoplasia has not been adequately addressed in the medical literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the incidence of renal cell carcinoma in transplanted kidneys, enhance the efficacy of its treatment, and study the etiology of RCC development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A retrospective analysis of RCC incidence in kidney grafts was conducted in 3,270 patients who underwent kidney transplantation between 2013 and 2023. We evaluated the effectiveness of surgical interventions for these complications. Patients with histologically confirmed RCC of the transplanted kidney underwent genetic study to determine the etiology of the neoplasm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of RCC in transplanted kidneys was found to be 0.95% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931), 28 patients underwent laparoscopic resection of the renal transplant tumor, 2 patients were treated with radiofrequency ablation of the tumor. Transplantectomy was performed in 1 patient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Laparoscopic resection is an effective and safe method for the treatment of RCC in kidney transplants. Transplanted kidney cancer originates from the donor tissue. The clear cell variant of transplanted kidney cancer is a genetically determined disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-024-03673-0","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:05:07Z","timestamp":1722229507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Renal cell carcinoma in a transplanted kidney: a retrospective evaluation"],"prefix":"10.1186","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-0539","authenticated-orcid":false,"given":"Ruslan N.","family":"Trushkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-8616","authenticated-orcid":false,"given":"Teymur K.","family":"Isaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-0815","authenticated-orcid":false,"given":"Pavel E.","family":"Medvedev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1018-8460","authenticated-orcid":false,"given":"Nikolai E.","family":"Shcheglov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-6203","authenticated-orcid":false,"given":"Valerii V.","family":"Variasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-7975","authenticated-orcid":false,"given":"Mariana A.","family":"Lysenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-7048","authenticated-orcid":false,"given":"Ilya V.","family":"Dmitriev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-3310","authenticated-orcid":false,"given":"Aslan G.","family":"Balkarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8277-8649","authenticated-orcid":false,"given":"Laura A.","family":"Kesaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"issue":"3","key":"3673_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.15825\/1995-1191-2021-3-8-34","volume":"23","author":"SV Gautier","year":"2021","unstructured":"Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2020 13th Report from the Registry of the Russian Transplant Society. Russian J Transplantology Artif Organs. 2021;23(3):8\u201334. https:\/\/doi.org\/10.15825\/1995-1191-2021-3-8-34.","journal-title":"Russian J Transplantology Artif Organs"},{"issue":"4","key":"3673_CR2","first-page":"2","volume":"24","author":"AM Andrusev","year":"2022","unstructured":"Andrusev AM, Peregudova NG, Shinkarev MB, Tomilina NA. Kidney replacement therapy for end stage kidney disease in Russian Federation, 2016\u20132020. Russian National Kidney Replacement Therapy Registry Report of Russian Public Organization of Nephrologists Russian Dialysis Society. Nephrolog\u0443 Dial\u0443sis. 2022;24(4):2.","journal-title":"Nephrolog\u0443 Dial\u0443sis"},{"key":"3673_CR3","doi-asserted-by":"publisher","unstructured":"Van Loon E, Senev A, Lerut E, Coemans M, Callemeyn J, Van Keer JM, Dani\u00ebls L, Kuypers D, Sprangers B, Emonds MP, Naesens M. Assessing the Complex Causes of Kidney Allograft Loss. Transplantation. 2020;104(12):2557\u20132566. https:\/\/doi.org\/10.1097\/TP.0000000000003192. PMID: 32091487.","DOI":"10.1097\/TP.0000000000003192"},{"key":"3673_CR4","doi-asserted-by":"publisher","first-page":"661643","DOI":"10.3389\/fimmu.2021.661643","volume":"12","author":"X Lai","year":"2021","unstructured":"Lai X, Zheng X, Mathew JM, Gallon L, Leventhal JR, Zhang ZJ. Tackling chronic kidney transplant rejection: challenges and promises. Front Immunol. 2021;12:661643. https:\/\/doi.org\/10.3389\/fimmu.2021.661643. PMID: 34093552; PMCID: PMC8173220.","journal-title":"Front Immunol"},{"issue":"11","key":"3673_CR5","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1111\/ajt.14366","volume":"17","author":"JJ Griffith","year":"2017","unstructured":"Griffith JJ, Amin KA, Waingankar N, Lerner SM, Delaney V, Ames SA, Badani K, Palese MA, Mehrazin R. Solid renal masses in transplanted allograft kidneys: a closer look at the epidemiology and management. Am J Transpl. 2017;17(11):2775\u201381. https:\/\/doi.org\/10.1111\/ajt.14366. Epub 2017 Jun 27. PMID: 28544435.","journal-title":"Am J Transpl"},{"issue":"1","key":"3673_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.trre.2015.07.001","volume":"30","author":"X Tillou","year":"2016","unstructured":"Tillou X, Guleryuz K, Collon S, Doerfler A. Renal cell carcinoma in functional renal graft: toward ablative treatments. Transpl Rev (Orlando). 2016;30(1):20\u20136. https:\/\/doi.org\/10.1016\/j.trre.2015.07.001. Epub 2015 Aug 1. PMID: 26318289.","journal-title":"Transpl Rev (Orlando)"},{"issue":"17","key":"3673_CR7","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.12998\/wjcc.v7.i17.2487","volume":"7","author":"E Favi","year":"2019","unstructured":"Favi E, Raison N, Ambrogi F, Delbue S, Clementi MC, Lamperti L, Perego M, Bischeri M, Ferraresso M. Systematic review of ablative therapy for the treatment of renal allograft neoplasms. World J Clin Cases. 2019;7(17):2487\u2013504. https:\/\/doi.org\/10.12998\/wjcc.v7.i17.2487. PMID: 31559284; PMCID: PMC6745334.","journal-title":"World J Clin Cases"},{"key":"3673_CR8","doi-asserted-by":"publisher","unstructured":"Crespo E, Fernandez L, L\u00facia M, Melilli E, Lauzurica R, Penin RM, Quer A, Luque S, Quero M, Manonelles A, Torras J, Cruzado JM, Ca\u00f1as L, Griny\u00f3 JM, Bestard O. Effector Antitumor and Regulatory T Cell Responses Influence the Development of Nonmelanoma Skin Cancer in Kidney Transplant Patients. Transplantation. 2017;101(9):2102\u20132110. https:\/\/doi.org\/10.1097\/TP.0000000000001759. PMID: 28403126.","DOI":"10.1097\/TP.0000000000001759"},{"key":"3673_CR9","doi-asserted-by":"publisher","unstructured":"Maluccio M, Sharma V, Lagman M, Vyas S, Yang H, Li B, Suthanthiran M. Tacrolimus enhances transforming growth factor-beta1 expression and promotes tumor progression. Transplantation. 2003;76(3):597\u2013602. https:\/\/doi.org\/10.1097\/01.TP.0000081399.75231.3B. PMID: 12923450.","DOI":"10.1097\/01.TP.0000081399.75231.3B"},{"issue":"1","key":"3673_CR10","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.ccell.2015.12.004","volume":"29","author":"AA Hakimi","year":"2016","unstructured":"Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. 2016;29(1):104\u201316. PMID: 26766592; PMCID: PMC4809063.","journal-title":"Cancer Cell"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03673-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-024-03673-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03673-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:08:08Z","timestamp":1722229688000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-024-03673-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3673"],"URL":"https:\/\/doi.org\/10.1186\/s12882-024-03673-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4311829\/v1","asserted-by":"object"}]},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"23 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The trial was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by Shumakov National Medical Research Center of Transplantology and Artificial Organs ethics committee of 25.11.2021 \u2116 251121-1\/3d and informed consent was taken from all individual participants. We confirm that organs were not harvested from prisoners. Organs were procured via Moscow Coordinating Centre of Organ Donation of Moscow Healthcare Department.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"we confirm our responsibility for ensuring the data\u2019s integrity and accuracy of the data analysis, as well as the decision to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"237"}}