{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:20:13Z","timestamp":1782217213048,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hypoxia conditioning medicine","award":["he key supporting specialty of Beijing Medical Management Center ZYLX202138"],"award-info":[{"award-number":["he key supporting specialty of Beijing Medical Management Center ZYLX202138"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-024-03733-5","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T14:03:34Z","timestamp":1725890614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["P4HB regulates the TGF\u03b2\/SMAD3 signaling pathway through PRMT1 to participate in high glucose-induced epithelial-mesenchymal transition and fibrosis of renal tubular epithelial cells"],"prefix":"10.1186","volume":"25","author":[{"given":"Haifeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"3733_CR1","doi-asserted-by":"crossref","unstructured":"Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709\u201333.","DOI":"10.1016\/S0140-6736(19)32977-0"},{"key":"3733_CR2","doi-asserted-by":"publisher","first-page":"p1497449","DOI":"10.1155\/2021\/1497449","volume":"2021","author":"N Samsu","year":"2021","unstructured":"Samsu N. Diabetic Nephropathy: challenges in Pathogenesis, diagnosis, and treatment. Biomed Res Int. 2021;2021:p1497449.","journal-title":"Biomed Res Int"},{"key":"3733_CR3","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fendo.2020.00091","volume":"11","author":"A Permyakova","year":"2020","unstructured":"Permyakova A, et al. A Novel Indoline Derivative ameliorates Diabesity-Induced chronic kidney disease by reducing metabolic abnormalities. Front Endocrinol (Lausanne). 2020;11:91.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"3733_CR4","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/ki.2013.74","volume":"84","author":"T Miyata","year":"2013","unstructured":"Miyata T, Suzuki N. Ypersele De Strihou, Diabetic nephropathy: are there new and potentially promising therapies targeting oxygen biology?. Kidney Int. 2013;84(4):693\u2013702. van.","journal-title":"Kidney Int"},{"key":"3733_CR5","doi-asserted-by":"publisher","first-page":"987064","DOI":"10.1155\/2013\/987064","volume":"2013","author":"L Xiao","year":"2013","unstructured":"Xiao L, et al. A glimpse of the pathogenetic mechanisms of Wnt\/\u03b2-catenin signaling in diabetic nephropathy. Biomed Res Int. 2013;2013:987064.","journal-title":"Biomed Res Int"},{"issue":"1","key":"3733_CR6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1080\/0886022X.2022.2079525","volume":"44","author":"Z Ma","year":"2022","unstructured":"Ma Z, et al. Berberine protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition involving the inactivation of the NLRP3 inflammasome. Ren Fail. 2022;44(1):923\u201332.","journal-title":"Ren Fail"},{"issue":"3","key":"3733_CR7","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1681\/ASN.2014111136","volume":"27","author":"R Mohamed","year":"2016","unstructured":"Mohamed R, et al. Low-dose IL-17 Therapy prevents and reverses Diabetic Nephropathy, metabolic syndrome, and Associated Organ Fibrosis. J Am Soc Nephrol. 2016;27(3):745\u201365.","journal-title":"J Am Soc Nephrol"},{"key":"3733_CR8","doi-asserted-by":"crossref","unstructured":"Sharma S et al. E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects. JCI Insight, 2021, 6(24).","DOI":"10.1172\/jci.insight.144935"},{"key":"3733_CR9","doi-asserted-by":"crossref","unstructured":"Choi JH et al. Platyconic Acid A, Platycodi Radix-Derived Saponin, suppresses TGF-1-induced activation of hepatic stellate cells via blocking SMAD and activating the PPAR signaling pathway. Cells, 2019, 8(12).","DOI":"10.3390\/cells8121544"},{"issue":"1","key":"3733_CR10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s13045-022-01331-2","volume":"15","author":"T Zhang","year":"2022","unstructured":"Zhang T, et al. Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-\u03b2\/SMAD3 pathway. J Hematol Oncol. 2022;15(1):114.","journal-title":"J Hematol Oncol"},{"issue":"5","key":"3733_CR11","doi-asserted-by":"publisher","first-page":"e14041","DOI":"10.1111\/jfbc.14041","volume":"46","author":"HC Lin","year":"2022","unstructured":"Lin HC, et al. Glycyrrhiza uralensis root extract ameliorates high glucose-induced renal proximal tubular fibrosis by attenuating tubular epithelial-myofibroblast transdifferentiation by targeting TGF-\u03b21\/Smad\/Stat3 pathway. J Food Biochem. 2022;46(5):e14041.","journal-title":"J Food Biochem"},{"key":"3733_CR12","doi-asserted-by":"crossref","unstructured":"Hao Y, Baker D, Ten Dijke P. TGF-\u03b2-Mediated epithelial-mesenchymal transition and Cancer metastasis. Int J Mol Sci, 2019, 20(11).","DOI":"10.3390\/ijms20112767"},{"issue":"2","key":"3733_CR13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41419-019-1402-y","volume":"10","author":"TC De Bessa","year":"2019","unstructured":"De Bessa TC, et al. Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas. Cell Death Dis. 2019;10(2):143.","journal-title":"Cell Death Dis"},{"key":"3733_CR14","doi-asserted-by":"crossref","unstructured":"Hazari Y, et al. The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB\/PDIA1 contributing to liver damage and fibrosis. bioRxiv; 2023.","DOI":"10.1101\/2023.05.02.538835"},{"key":"3733_CR15","doi-asserted-by":"publisher","first-page":"965816","DOI":"10.3389\/fgene.2022.965816","volume":"13","author":"F Bai","year":"2022","unstructured":"Bai F, et al. Identification and validation of P4HB as a novel autophagy-related biomarker in diabetic nephropathy. Front Genet. 2022;13:965816.","journal-title":"Front Genet"},{"issue":"10","key":"3733_CR16","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1016\/j.bbadis.2019.06.001","volume":"1865","author":"YY Chen","year":"2019","unstructured":"Chen YY, et al. Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy. Biochim Biophys Acta Mol Basis Dis. 2019;1865(10):2563\u201375.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"6","key":"3733_CR17","doi-asserted-by":"publisher","first-page":"918","DOI":"10.4149\/neo_2018_181226N999","volume":"66","author":"H Wei","year":"2019","unstructured":"Wei H, et al. Protein arginine methyltransferase 1 promotes epithelial-mesenchymal transition via TGF-\u03b21\/Smad pathway in hepatic carcinoma cells. Neoplasma. 2019;66(6):918\u201329.","journal-title":"Neoplasma"},{"issue":"4","key":"3733_CR18","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3892\/ijmm.2014.1640","volume":"33","author":"JH Lee","year":"2014","unstructured":"Lee JH, et al. Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation. Int J Mol Med. 2014;33(4):849\u201355.","journal-title":"Int J Mol Med"},{"key":"3733_CR19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.yjmcc.2016.03.008","volume":"94","author":"AC Zeigler","year":"2016","unstructured":"Zeigler AC, et al. A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation. J Mol Cell Cardiol. 2016;94:72\u201381.","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"3733_CR20","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1038\/s41401-019-0244-6","volume":"40","author":"Q Lu","year":"2019","unstructured":"Lu Q, et al. Inactivation of TSC1 promotes epithelial-mesenchymal transition of renal tubular epithelial cells in mouse diabetic nephropathy. Acta Pharmacol Sin. 2019;40(12):1555\u201367.","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"3733_CR21","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13098-021-00726-4","volume":"13","author":"L Zhao","year":"2021","unstructured":"Zhao L, et al. LncRNA KCNQ1OT1 promotes the development of diabetic nephropathy by regulating miR-93-5p\/ROCK2 axis. Diabetol Metab Syndr. 2021;13(1):108.","journal-title":"Diabetol Metab Syndr"},{"key":"3733_CR22","doi-asserted-by":"publisher","first-page":"114897","DOI":"10.1016\/j.biopha.2023.114897","volume":"164","author":"Z Liu","year":"2023","unstructured":"Liu Z, et al. Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. Biomed Pharmacother. 2023;164:114897.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"3733_CR23","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3390\/cells4040631","volume":"4","author":"I Loeffler","year":"2015","unstructured":"Loeffler I, Wolf G. Epithelial-to-mesenchymal transition in Diabetic Nephropathy: fact or fiction? Cells. 2015;4(4):631\u201352.","journal-title":"Cells"},{"issue":"5","key":"3733_CR24","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41419-022-04894-7","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, et al. Glutathione prevents high glucose-induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS\/TGF\u03b2\/SMAD pathway. Cell Death Dis. 2022;13(5):440.","journal-title":"Cell Death Dis"},{"key":"3733_CR25","doi-asserted-by":"crossref","unstructured":"Sun B et al. Hippuric Acid promotes renal fibrosis by disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 interactions in chronic kidney disease. Antioxid (Basel), 2020, 9(9).","DOI":"10.3390\/antiox9090783"},{"issue":"24","key":"3733_CR26","doi-asserted-by":"publisher","first-page":"4354","DOI":"10.3748\/wjg.v23.i24.4354","volume":"23","author":"E Hern\u00e1ndez-Aquino","year":"2017","unstructured":"Hern\u00e1ndez-Aquino E, et al. Naringenin prevents experimental liver fibrosis by blocking TGF\u03b2-Smad3 and JNK-Smad3 pathways. World J Gastroenterol. 2017;23(24):4354\u201368.","journal-title":"World J Gastroenterol"},{"key":"3733_CR27","doi-asserted-by":"publisher","first-page":"792139","DOI":"10.3389\/fphar.2021.792139","volume":"12","author":"Q Ren","year":"2021","unstructured":"Ren Q, et al. Natural flavonoid pectolinarigenin alleviated Hyperuricemic Nephropathy via suppressing TGF\u03b2\/SMAD3 and JAK2\/STAT3 signaling pathways. Front Pharmacol. 2021;12:792139.","journal-title":"Front Pharmacol"},{"key":"3733_CR28","doi-asserted-by":"crossref","unstructured":"Gong EY et al. VSIG4 induces Epithelial-Mesenchymal Transition of Renal Tubular Cells under high-glucose conditions. Life (Basel), 2020, 10(12).","DOI":"10.3390\/life10120354"},{"key":"3733_CR29","doi-asserted-by":"crossref","unstructured":"Loh CY et al. The E-Cadherin and N-Cadherin switch in Epithelial-To-Mesenchymal transition: signaling, therapeutic implications, and challenges. Cells, 2019, 8(10).","DOI":"10.3390\/cells8101118"},{"issue":"3","key":"3733_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41389-018-0035-9","volume":"7","author":"H Ko","year":"2018","unstructured":"Ko H, et al. Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition. Oncogenesis. 2018;7(3):27.","journal-title":"Oncogenesis"},{"issue":"4","key":"3733_CR31","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s41385-020-0259-9","volume":"13","author":"S Zhao","year":"2020","unstructured":"Zhao S, et al. Selective deletion of MyD88 signaling in \u03b1-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation. Mucosal Immunol. 2020;13(4):665\u201378.","journal-title":"Mucosal Immunol"},{"issue":"10","key":"3733_CR32","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/onc.2016.305","volume":"36","author":"Z Zelenko","year":"2017","unstructured":"Zelenko Z, et al. Silencing vimentin expression decreases pulmonary metastases in a pre-diabetic mouse model of mammary tumor progression. Oncogene. 2017;36(10):1394\u2013403.","journal-title":"Oncogene"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03733-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-024-03733-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03733-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T14:05:08Z","timestamp":1725890708000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-024-03733-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3733"],"URL":"https:\/\/doi.org\/10.1186\/s12882-024-03733-5","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]},"assertion":[{"value":"19 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"297"}}