{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:05:38Z","timestamp":1782335138624,"version":"3.54.5"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270840"],"award-info":[{"award-number":["81270840"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Cultivation Project of Southern Medical University","award":["LC2016PY047"],"award-info":[{"award-number":["LC2016PY047"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-024-03866-7","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T22:14:00Z","timestamp":1732918440000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association of insulin resistance with chronic kidney disease in individuals without diabetes in a community population in South China"],"prefix":"10.1186","volume":"25","author":[{"given":"Jiamin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hequn","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"issue":"4","key":"3866_CR1","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semnephrol.2016.05.008","volume":"36","author":"V Wang","year":"2016","unstructured":"Wang V, Vilme H, Maciejewski ML, Boulware LE. The economic burden of chronic kidney disease and end-stage renal Disease. Semin Nephrol. 2016;36(4):319\u201330.","journal-title":"Semin Nephrol"},{"key":"3866_CR2","doi-asserted-by":"crossref","unstructured":"Zhang L, Zhao MH, Zuo L, Wang Y, Yu F, Zhang H et al. China Kidney Disease Network (CK-NET) 2016 Annual Data Report. Kidney Int Suppl (2011). 2020;10(2):e97-185.","DOI":"10.1016\/j.kisu.2020.09.001"},{"issue":"3","key":"3866_CR3","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1007\/s00125-017-4511-0","volume":"61","author":"SH Jung","year":"2018","unstructured":"Jung SH, Jung CH, Reaven GM, Kim SH. Adapting to insulin resistance in obesity: role of insulin secretion and clearance. Diabetologia. 2018;61(3):681\u20137.","journal-title":"Diabetologia"},{"issue":"2","key":"3866_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/01.ASN.0000046029.53933.09","volume":"14","author":"J Chen","year":"2003","unstructured":"Chen J, Muntner P, Hamm LL, Fonseca V, Batuman V, Whelton PK, et al. Insulin resistance and risk of chronic kidney disease in nondiabetic US adults. J Am Soc Nephrol. 2003;14(2):469\u201377.","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3866_CR5","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.4103\/1319-2442.215144","volume":"28","author":"S Conkar","year":"2017","unstructured":"Conkar S, Mir S. Relationship of insulin resistance to vitamin d status in children with nondiabetic chronic kidney disease. Saudi J Kidney Dis Transpl. 2017;28(5):1078\u201384.","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"2","key":"3866_CR6","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/1744-9987.12632","volume":"22","author":"S Wakino","year":"2018","unstructured":"Wakino S, Minakuchi H, Miya K, Takamatsu N, Tada H, Tani E, et al. Aldosterone and insulin resistance: vicious combination in patients on maintenance Hemodialysis. Ther Apher Dial. 2018;22(2):142\u201351.","journal-title":"Ther Apher Dial"},{"issue":"5","key":"3866_CR7","first-page":"C9","volume":"11","author":"BV Kumar","year":"2017","unstructured":"Kumar BV, Mohan T. Retrospective comparison of estimated GFR using 2006 MDRD, 2009 CKD-EPI and Cockcroft-Gault with 24 Hour urine creatinine Clearance. J Clin Diagn Res. 2017;11(5):C9\u201312.","journal-title":"J Clin Diagn Res"},{"issue":"9","key":"3866_CR8","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1681\/ASN.2015070756","volume":"27","author":"IH de Boer","year":"2016","unstructured":"de Boer IH, Zelnick L, Afkarian M, Ayers E, Curtin L, Himmelfarb J, et al. Impaired glucose and insulin homeostasis in moderate-severe CKD. J Am Soc Nephrol. 2016;27(9):2861\u201371.","journal-title":"J Am Soc Nephrol"},{"key":"3866_CR9","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.ebiom.2018.10.054","volume":"37","author":"W Cao","year":"2018","unstructured":"Cao W, Shi M, Wu L, Yang Z, Yang X, Liu H, et al. A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease. EBioMedicine. 2018;37:281\u201393.","journal-title":"EBioMedicine"},{"key":"3866_CR10","doi-asserted-by":"crossref","unstructured":"Xu H, Carrero JJ. Insulin resistance in chronic kidney disease. Nephrol (Carlton). 2017;22 Suppl 4:31\u2009\u2013\u20094.","DOI":"10.1111\/nep.13147"},{"issue":"21","key":"3866_CR11","doi-asserted-by":"publisher","first-page":"7994","DOI":"10.3390\/ijms21217994","volume":"21","author":"F Juszczak","year":"2020","unstructured":"Juszczak F, Caron N, Mathew AV, Decl\u00e8ves AE. Critical role for AMPK in Metabolic Disease-Induced chronic kidney Disease. Int J Mol Sci. 2020;21(21):7994.","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3866_CR12","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1093\/ndt\/gfx018","volume":"32","author":"M Guthoff","year":"2017","unstructured":"Guthoff M, Wagner R, Vosseler D, Peter A, Nadalin S, H\u00e4ring HU, et al. Impact of end-stage renal disease on glucose metabolism-a matched cohort analysis. Nephrol Dial Transpl. 2017;32(4):670\u20136.","journal-title":"Nephrol Dial Transpl"},{"issue":"4","key":"3866_CR13","doi-asserted-by":"publisher","first-page":"e176137","DOI":"10.1371\/journal.pone.0176137","volume":"12","author":"Z Tan","year":"2017","unstructured":"Tan Z, Ye Z, Zhang J, Chen Y, Cheng C, Wang C, et al. Serum irisin levels correlated to peritoneal dialysis adequacy in nondiabetic peritoneal dialysis patients. PLoS ONE. 2017;12(4):e176137.","journal-title":"PLoS ONE"},{"issue":"3","key":"3866_CR14","first-page":"313","volume":"76","author":"A Tahar","year":"2018","unstructured":"Tahar A, Zerdoumi F, Saidani M, Griene L, Koceir EA. [Effects of oral vitamin D(3) supplementation in stage 3 chronic kidney disease subjects: insulin resistance syndrome and hormonal disturb interactions]. Ann Biol Clin (Paris). 2018;76(3):313\u201325.","journal-title":"Ann Biol Clin (Paris)"},{"issue":"16","key":"3866_CR15","doi-asserted-by":"publisher","first-page":"e122219","DOI":"10.1172\/jci.insight.122219","volume":"3","author":"B Roshanravan","year":"2018","unstructured":"Roshanravan B, Zelnick LR, Djucovic D, Gu H, Alvarez JA, Ziegler TR, et al. Chronic kidney disease attenuates the plasma metabolome response to insulin. JCI Insight. 2018;3(16):e122219.","journal-title":"JCI Insight"},{"issue":"6","key":"3866_CR16","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/joim.13355","volume":"290","author":"LM Pammer","year":"2021","unstructured":"Pammer LM, Lamina C, Schultheiss UT, Kotsis F, Kollerits B, Stockmann H, et al. Association of the metabolic syndrome with mortality and major adverse cardiac events: a large chronic kidney disease cohort. J Intern Med. 2021;290(6):1219\u201332.","journal-title":"J Intern Med"},{"issue":"3","key":"3866_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/MNH.0000000000000700","volume":"30","author":"M Chalupsky","year":"2021","unstructured":"Chalupsky M, Goodson DA, Gamboa JL, Roshanravan B. New insights into muscle function in chronic kidney disease and metabolic acidosis. Curr Opin Nephrol Hypertens. 2021;30(3):369\u201376.","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"9","key":"3866_CR18","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1093\/ndt\/gfq817","volume":"26","author":"M Landau","year":"2011","unstructured":"Landau M, Kurella-Tamura M, Shlipak MG, Kanaya A, Strotmeyer E, Koster A, et al. Correlates of insulin resistance in older individuals with and without kidney disease. Nephrol Dial Transpl. 2011;26(9):2814\u201319.","journal-title":"Nephrol Dial Transpl"},{"issue":"8","key":"3866_CR19","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1007\/s11255-014-0720-3","volume":"46","author":"CJ Wang","year":"2014","unstructured":"Wang CJ, Bao XR, Du GW, Wang Y, Chen K, Shen ML, et al. Effects of insulin resistance on left ventricular hypertrophy in patients with CKD stage 1\u20133. Int Urol Nephrol. 2014;46(8):1609\u201317.","journal-title":"Int Urol Nephrol"},{"issue":"4","key":"3866_CR20","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1093\/ndt\/gfr498","volume":"27","author":"BR Johns","year":"2012","unstructured":"Johns BR, Pao AC, Kim SH. Metabolic syndrome, insulin resistance and kidney function in non-diabetic individuals. Nephrol Dial Transpl. 2012;27(4):1410\u20135.","journal-title":"Nephrol Dial Transpl"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03866-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-024-03866-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03866-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T11:02:47Z","timestamp":1732964567000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-024-03866-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3866"],"URL":"https:\/\/doi.org\/10.1186\/s12882-024-03866-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4229443\/v1","asserted-by":"object"}]},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"7 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental scheme was approved by the ethics committee of the Third Affiliated Hospital of Southern Medical University (201,708,011). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"437"}}