{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:40:03Z","timestamp":1775662803831,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Sichuan Provincial Science and Technology Department-Science and Technology Innovation Talent Project","award":["No. 2020JDRC0022"],"award-info":[{"award-number":["No. 2020JDRC0022"]}]},{"name":"Sichuan Provincial Science and Technology Department-Science and Technology Innovation Talent Project","award":["No. 2020JDRC0022"],"award-info":[{"award-number":["No. 2020JDRC0022"]}]},{"name":"Sichuan Provincial Science and Technology Department-Science and Technology Innovation Talent Project","award":["No. 2020JDRC0022"],"award-info":[{"award-number":["No. 2020JDRC0022"]}]},{"name":"Sichuan Provincial Science and Technology Department-Science and Technology Innovation Talent Project","award":["No. 2020JDRC0022"],"award-info":[{"award-number":["No. 2020JDRC0022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-024-03874-7","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:53:55Z","timestamp":1733223235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: a case report"],"prefix":"10.1186","volume":"25","author":[{"given":"Chang","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Ju","family":"Gou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"issue":"2","key":"3874_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0272-6386(00)70348-9","volume":"35","author":"AM De Mattos","year":"2000","unstructured":"De Mattos AM, Olyaei AJ, Bennett WM. Nephrotoxicity of immunosuppressive drugs: long term consequences and challenges for the future. Am J Kidney Dis. 2000;35(2):333\u201346.","journal-title":"Am J Kidney Dis"},{"key":"3874_CR2","doi-asserted-by":"publisher","first-page":"769","DOI":"10.2165\/00003088-200544080-00001","volume":"44","author":"SB Stenton","year":"2005","unstructured":"Stenton SB, Partovi N, Ensom MH. Sirolimus: the evidence for clinical pharmacokinetic monitoring. Clin Pharmacokinet. 2005;44:769\u201386.","journal-title":"Clin Pharmacokinet"},{"issue":"17","key":"3874_CR3","first-page":"1319","volume":"47","author":"J Lin","year":"2009","unstructured":"Lin J, Tang YW, Sun W, et al. Clinical study of application of sirolimus with dose-reduced or discontinued cyclosporine A for prevention of acute rejection after kidney transplantatio. Zhonghua Wai Ke Za Zhi. 2009;47(17):1319\u201321.","journal-title":"Zhonghua Wai Ke Za Zhi"},{"issue":"3","key":"3874_CR4","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1097\/01.ASN.0000113248.59077.76","volume":"15","author":"H Kreis","year":"2004","unstructured":"Kreis H, Oberbauer R, Camp istol J, et al. Long term benefits with sirolimus based therapy after early cyclosporine with drawal. J Am Soc Nephrol. 2004;15(3):809\u201317.","journal-title":"J Am Soc Nephrol"},{"key":"3874_CR5","unstructured":"Xu Zhi-qiang. Wan You-gui, Chen Bo, Conversion treatment using sirolimus for kidney transplant recipients;Journal of Clinical Rehabilitative Tissue Engineering Research.2011;Vol.15, No.5."},{"key":"3874_CR6","doi-asserted-by":"crossref","unstructured":"Hatori M, Takahara S, Kyo et al. Clinical and histopathologic examination of renal allografts treated with tacrolimus (FK506) for at least one year.International journal of urology.1998;526\u2009\u2013\u200933.","DOI":"10.1111\/j.1442-2042.1998.tb00406.x"},{"issue":"1","key":"3874_CR7","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.transproceed.2005.12.023","volume":"38","author":"M Boratynska","year":"2006","unstructured":"Boratynska M, Banasik M, Watorek E, et al. Conversion to sirolimus from cyclosporine may induce nephrotic proteinuria and progressive deterioration of renal function in chronic allograft nephropathy patients. Transpl Proc. 2006;38(1):101\u20134.","journal-title":"Transpl Proc"},{"key":"3874_CR8","doi-asserted-by":"crossref","unstructured":"Macdomald A, Scarola J, Burke JT et al. Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus[J], 2000; 22 (Suppl B): 101\u201321.","DOI":"10.1016\/S0149-2918(00)89027-X"},{"key":"3874_CR9","doi-asserted-by":"crossref","unstructured":"Dittrich E, Schmaldienst S, Soleiman A, et al. Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy. Transpl Int. 200;17:215.","DOI":"10.1111\/j.1432-2277.2004.tb00431.x"},{"key":"3874_CR10","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1097\/01.TP.0000140868.88149.63","volume":"78","author":"L Butani","year":"2004","unstructured":"Butani L. Investigation of pediatric renal transplant recipients with heavy proteinuria aftersirolimus rescue. Transplantation. 2004;78:1362.","journal-title":"Transplantation"},{"issue":"1","key":"3874_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s13054-016-1314-5","volume":"20","author":"O Chavezl","year":"2016","unstructured":"Chavezl O, Leon M, Einav S, et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice[J]. Crit Care. 2016;20(1):135.","journal-title":"Crit Care"},{"key":"3874_CR12","unstructured":"Stahlk, Rastellie. Schoserb. Asystematicreviewon the definition of rhabdomyolysis[J]. J Neurol, 2019; 415."},{"issue":"2","key":"3874_CR13","first-page":"152","volume":"12","author":"YAHHD Kim","year":"2014","unstructured":"Kim YAHHD, Jo K, et al. Severe Rhabdomyolysis Associated with Concurrent Use of Simvastatin and Sirolimus after cisplatin-based chemotherapy in a kidney transplant recipient. Exp Clin Transplant. 2014;12(2):152\u20135.","journal-title":"Exp Clin Transplant"},{"issue":"6","key":"3874_CR14","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1093\/ndt\/gfq157","volume":"25","author":"N Basic-Jukic","year":"2010","unstructured":"Basic-Jukic N, Kes P, Bubic-Filipi L, Vranjican Z. Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and rapamycin in a renal transplant recipient. Nephrol Dial Transpl. 2010;25(6):2036.","journal-title":"Nephrol Dial Transpl"},{"issue":"3","key":"3874_CR15","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.transproceed.2009.02.019","volume":"41","author":"C Dopazo","year":"2009","unstructured":"Dopazo C, Bilbao I, L\u00e1zaro JL, et al. Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with rapamycin plus tacrolimus in liver transplant patient. Transpl Proc. 2009;41(3):1021\u20134.","journal-title":"Transpl Proc"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03874-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-024-03874-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-024-03874-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:03:26Z","timestamp":1733223806000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-024-03874-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,3]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3874"],"URL":"https:\/\/doi.org\/10.1186\/s12882-024-03874-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3998402\/v1","asserted-by":"object"}]},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,3]]},"assertion":[{"value":"29 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study received biomedical ethics approval from West China Hospital of Sichuan University and informed consent from the patients (clinical trial number not applicable).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The patient and his legally authorized guardians have carefully read the contents of this paper and consent to the use of the information and images therein for academic research or publication purposes. The patient and his legally authorized guardians agree to the confidential handling of their personal identity information in this paper and consent to the partial disclosure of relevant treatment information for academic research purposes. Hereby, we confirm that, in compliance with relevant laws and regulations, informed consent has been obtained for the use of patient information and images in this paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Living.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Donor information"}},{"value":"Related.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Relationship of living donor to the recipient"}},{"value":"All data utilized in this study were sourced exclusively from the hospital\u2019s medical record system. This dataset was carefully curated to ensure the complete anonymity and confidentiality of all patients involved. No information or images that could potentially identify any individual patient were included. Furthermore, prior to the commencement of this study, informed consent was meticulously obtained from each and every patient included in the dataset, in accordance with established ethical guidelines and regulations. I hereby declare that the data used comply with the ethical principles of medical research and legal regulations, and strictly adhere to the requirements of personal privacy and data protection. The design and implementation of this study comply with internationally recognized ethical standards and have been approved by the hospital\u2019s research ethics review committee.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data source statement"}},{"value":"The authors declare no competing interests.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"445"}}