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The methodological quality of all the selected studies was assessed using the Joanna Briggs Institute Critical Appraisal of Epidemiological Studies Checklist and Newcastle\u2012Ottawa Cohort Quality Assessment Scale. Random effects meta-analysis was used to pool estimates from different studies. Subgroup analysis and meta-regression were performed to explore potential sources of heterogeneity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of the 4,190 documents retrieved, 16 observational studies involving 2,446 participants from 8 countries were included in this systematic review. Among older adults receiving MHD, the overall prevalence of frailty and prefrailty was 41% (95% CI\u2009=\u200934\u201349%) and 37% (95% CI\u2009=\u200926\u201348%), respectively, with considerable heterogeneity. The pooled prevalence of frailty was greater among individuals aged &gt;\u200970 years (45%) than among those aged\u2009\u2264\u200970 years (37%). However, subgroup analyses indicated that the confidence intervals for the age group overlap substantially.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our research showed that the prevalence of frailty and prefrailty in older patients with MHD are high.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The PROSPERO registration number for this study was CRD42023442569.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12882-024-03921-3","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T14:29:58Z","timestamp":1736519398000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The prevalence of frailty among older adults with maintenance hemodialysis: a systematic"],"prefix":"10.1186","volume":"26","author":[{"given":"Juanjuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"3921_CR1","doi-asserted-by":"publisher","DOI":"10.1159\/000362458","author":"Marcello,Tonelli,Migue","year":"2014","unstructured":"Marcello,Tonelli,Migue. 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