{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:48:54Z","timestamp":1779205734757,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-025-04020-7","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:04:31Z","timestamp":1740369871000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence, associated factors and clinical implications of subjective cognitive decline linked to frailty in patients receiving maintenance hemodialysis: a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaihong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"issue":"5","key":"4020_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","volume":"16","author":"M Ruiz-Ortega","year":"2020","unstructured":"Ruiz-Ortega M, Rayego-Mateos S, Lamas S, Ortiz A, Rodrigues-Diez RR. Targeting the progression of chronic kidney disease. Nat Rev Nephrol. 2020;16(5):269\u201388.","journal-title":"Nat Rev Nephrol"},{"issue":"4s","key":"4020_CR2","first-page":"S117","volume":"105","author":"KDIGOKCW Group","year":"2024","unstructured":"Group KDIGOKCW. KDIGO 2024 Clinical Practice Guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;105(4s):S117\u2013314.","journal-title":"Kidney Int"},{"issue":"10225","key":"4020_CR3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/S0140-6736(19)32977-0","volume":"395","author":"P Cockwell","year":"2020","unstructured":"Cockwell P, Fisher LA. The global burden of chronic kidney disease. Lancet (London England). 2020;395(10225):662\u20134.","journal-title":"Lancet (London England)"},{"key":"4020_CR4","unstructured":"CNRDS. Chinese Renal Data System (CNRDS). 2023."},{"issue":"3","key":"4020_CR5","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/bjhp.12645","volume":"28","author":"FHF Chan","year":"2023","unstructured":"Chan FHF, Newman S, Khan BA, Griva K. Prevalence and trajectories of subjective cognitive complaints and implications for patient outcomes: a prospective study of haemodialysis patients. Br J Health Psychol. 2023;28(3):651\u201371.","journal-title":"Br J Health Psychol"},{"issue":"6","key":"4020_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1053\/j.ajkd.2019.05.017","volume":"74","author":"DA Drew","year":"2019","unstructured":"Drew DA, Weiner DE, Sarnak MJ. Cognitive impairment in CKD: Pathophysiology, Management, and Prevention. Am J Kidney Diseases: Official J Natl Kidney Foundation. 2019;74(6):782\u201390.","journal-title":"Am J Kidney Diseases: Official J Natl Kidney Foundation"},{"issue":"1","key":"4020_CR7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12916-016-0745-9","volume":"14","author":"I Berger","year":"2016","unstructured":"Berger I, Wu S, Masson P, Kelly PJ, Duthie FA, Whiteley W, Parker D, Gillespie D, Webster AC. Cognition in chronic kidney disease: a systematic review and meta-analysis. BMC Med. 2016;14(1):206.","journal-title":"BMC Med"},{"issue":"8","key":"4020_CR8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41581-020-0266-9","volume":"16","author":"D Viggiano","year":"2020","unstructured":"Viggiano D, Wagner CA, Martino G, Nedergaard M, Zoccali C, Unwin R, Capasso G. Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol. 2020;16(8):452\u201369.","journal-title":"Nat Rev Nephrol"},{"issue":"9","key":"4020_CR9","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1111\/ene.15928","volume":"30","author":"M P\u00e9pin","year":"2023","unstructured":"P\u00e9pin M, Klimkowicz-Mrowiec A, Godefroy O, Delgado P, Carriazo S, Ferreira AC, Golenia A, Malyszko J, Grodzicki T, Giannakou K, et al. Cognitive disorders in patients with chronic kidney disease: approaches to prevention and treatment. Eur J Neurol. 2023;30(9):2899\u2013911.","journal-title":"Eur J Neurol"},{"issue":"9","key":"4020_CR10","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.2215\/CJN.10150917","volume":"13","author":"MA McAdams-DeMarco","year":"2018","unstructured":"McAdams-DeMarco MA, Daubresse M, Bae S, Gross AL, Carlson MC, Segev DL. Dementia, Alzheimer\u2019s Disease, and mortality after hemodialysis initiation. Clin J Am Soc Nephrology: CJASN. 2018;13(9):1339\u201347.","journal-title":"Clin J Am Soc Nephrology: CJASN"},{"key":"4020_CR11","doi-asserted-by":"crossref","unstructured":"Ye BM, Kang S, Park WY, Cho JH, Yu BC, Han M, Song SH, Ko GJ, Yang JW, Chung S et al. Association between dementia diagnosis at dialysis initiation and mortality in older patients with end-stage kidney disease in South Korea. Kidney research and clinical practice 2024.","DOI":"10.23876\/j.krcp.23.151"},{"key":"4020_CR12","doi-asserted-by":"publisher","first-page":"101508","DOI":"10.1016\/j.arr.2021.101508","volume":"74","author":"C Oedekoven","year":"2022","unstructured":"Oedekoven C, Egeri L, Jessen F, Wagner M, Dodel R. Subjective cognitive decline in idiopathic Parkinson\u00b4s disease: a systematic review. Ageing Res Rev. 2022;74:101508.","journal-title":"Ageing Res Rev"},{"key":"4020_CR13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1146\/annurev-clinpsy-032816-045136","volume":"13","author":"LA Rabin","year":"2017","unstructured":"Rabin LA, Smart CM, Amariglio RE. Subjective cognitive decline in preclinical Alzheimer\u2019s Disease. Ann Rev Clin Psychol. 2017;13:369\u201396.","journal-title":"Ann Rev Clin Psychol"},{"issue":"1","key":"4020_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s10072-018-3620-y","volume":"40","author":"Y Lin","year":"2019","unstructured":"Lin Y, Shan PY, Jiang WJ, Sheng C, Ma L. Subjective cognitive decline: preclinical manifestation of Alzheimer\u2019s disease. Neurol Sciences: Official J Italian Neurol Soc Italian Soc Clin Neurophysiol. 2019;40(1):41\u20139.","journal-title":"Neurol Sciences: Official J Italian Neurol Soc Italian Soc Clin Neurophysiol"},{"issue":"4","key":"4020_CR15","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1080\/17437199.2022.2132980","volume":"17","author":"FHF Chan","year":"2023","unstructured":"Chan FHF, Goh ZZS, Zhu X, Tudor Car L, Newman S, Khan BA, Griva K. Subjective cognitive complaints in end-stage renal disease: a systematic review and meta-analysis. Health Psychol Rev. 2023;17(4):614\u201340.","journal-title":"Health Psychol Rev"},{"key":"4020_CR16","doi-asserted-by":"crossref","unstructured":"Rotondi S, Tartaglione L, Pasquali M, Ceravolo MJ, Mitterhofer AP, Noce A, Tavilla M, Lai S, Tinti F, Muci ML et al. Association between Cognitive Impairment and Malnutrition in Hemodialysis patients: two sides of the same Coin. Nutrients 2023, 15(4).","DOI":"10.3390\/nu15040813"},{"key":"4020_CR17","doi-asserted-by":"crossref","unstructured":"Ni Lochlainn M, Cox NJ, Wilson T, Hayhoe RPG, Ramsay SE, Granic A, Isanejad M, Roberts HC, Wilson D, Welch C et al. Nutrition and Frailty: opportunities for Prevention and Treatment. Nutrients 2021, 13(7).","DOI":"10.3390\/nu13072349"},{"issue":"4","key":"4020_CR18","first-page":"429","volume":"1","author":"KA Gifford","year":"2015","unstructured":"Gifford KA, Liu D, Romano R 3rd, Jones RN, Jefferson AL. Development of a subjective cognitive decline questionnaire using item response theory: a pilot study. Alzheimer\u2019s Dement (Amsterdam Netherlands). 2015;1(4):429\u201339.","journal-title":"Alzheimer\u2019s Dement (Amsterdam Netherlands)"},{"issue":"5","key":"4020_CR19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.jamda.2009.11.003","volume":"11","author":"RJ Gobbens","year":"2010","unstructured":"Gobbens RJ, van Assen MA, Luijkx KG, Wijnen-Sponselee MT, Schols JM. The Tilburg Frailty Indicator: psychometric properties. J Am Med Dir Assoc. 2010;11(5):344\u201355.","journal-title":"J Am Med Dir Assoc"},{"issue":"16","key":"4020_CR20","first-page":"1","volume":"20","author":"X Xi","year":"2013","unstructured":"Xi X, Guo GF, Sun J. A study on the reliability and validity of the Chinese version of Tilburg Frailty Assessment Scale. J Nurs. 2013;20(16):1\u20135.","journal-title":"J Nurs"},{"issue":"1 Suppl 2","key":"4020_CR21","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1053\/ajkd.2001.20748","volume":"37","author":"JD Kopple","year":"2001","unstructured":"Kopple JD. National kidney foundation K\/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Diseases: Official J Natl Kidney Foundation. 2001;37(1 Suppl 2):S66\u201370.","journal-title":"Am J Kidney Diseases: Official J Natl Kidney Foundation"},{"issue":"08","key":"4020_CR22","first-page":"49","volume":"40","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhou MF, Chen SX, Zhu YP. Study on the status of subjective cognitive decline and its correlation with frailty in peritoneal dialysis patients. Military Nurs. 2023;40(08):49\u201352.","journal-title":"Military Nurs"},{"issue":"2","key":"4020_CR23","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1053\/j.ajkd.2014.07.009","volume":"65","author":"DA Drew","year":"2015","unstructured":"Drew DA, Weiner DE, Tighiouart H, Scott T, Lou K, Kantor A, Fan L, Strom JA, Singh AK, Sarnak MJ. Cognitive function and all-cause mortality in maintenance hemodialysis patients. Am J Kidney Diseases: Official J Natl Kidney Foundation. 2015;65(2):303\u201311.","journal-title":"Am J Kidney Diseases: Official J Natl Kidney Foundation"},{"issue":"1","key":"4020_CR24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1681\/ASN.2018050462","volume":"30","author":"MD Findlay","year":"2019","unstructured":"Findlay MD, Dawson J, Dickie DA, Forbes KP, McGlynn D, Quinn T, Mark PB. Investigating the relationship between cerebral blood Flow and cognitive function in Hemodialysis patients. J Am Soc Nephrology: JASN. 2019;30(1):147\u201358.","journal-title":"J Am Soc Nephrology: JASN"},{"issue":"1","key":"4020_CR25","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/s12882-022-02994-2","volume":"23","author":"FHF Chan","year":"2022","unstructured":"Chan FHF, Newman S, Khan BA, Griva K. The role of subjective cognitive complaints in self-management among haemodialysis patients: a cross-sectional study. BMC Nephrol. 2022;23(1):363.","journal-title":"BMC Nephrol"},{"issue":"6","key":"4020_CR26","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1111\/j.1523-1755.2004.66024.x","volume":"66","author":"M Kurella","year":"2004","unstructured":"Kurella M, Luan J, Yaffe K, Chertow GM. Validation of the kidney Disease Quality of Life (KDQOL) cognitive function subscale. Kidney Int. 2004;66(6):2361\u20137.","journal-title":"Kidney Int"},{"issue":"2","key":"4020_CR27","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3233\/JAD-170347","volume":"60","author":"L Hao","year":"2017","unstructured":"Hao L, Wang X, Zhang L, Xing Y, Guo Q, Hu X, Mu B, Chen Y, Chen G, Cao J, et al. Prevalence, risk factors, and complaints Screening Tool Exploration of Subjective Cognitive decline in a large cohort of the Chinese Population. J Alzheimer\u2019s Disease: JAD. 2017;60(2):371\u201388.","journal-title":"J Alzheimer\u2019s Disease: JAD"},{"issue":"2","key":"4020_CR28","doi-asserted-by":"publisher","first-page":"453","DOI":"10.3233\/JAD-132027","volume":"41","author":"L Rami","year":"2014","unstructured":"Rami L, Mollica MA, Garc\u00eda-Sanchez C, Salda\u00f1a J, Sanchez B, Sala I, Valls-Pedret C, Castellv\u00ed M, Olives J, Molinuevo JL. The subjective cognitive decline questionnaire (SCD-Q): a validation study. J Alzheimer\u2019s Disease: JAD. 2014;41(2):453\u201366.","journal-title":"J Alzheimer\u2019s Disease: JAD"},{"issue":"4","key":"4020_CR29","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1080\/13548506.2022.2125165","volume":"28","author":"H Su","year":"2023","unstructured":"Su H, Zhou Y, Sun Y, Cai Y. The relationship between depression and subjective cognitive decline in older adults of China: the mediating role of general self-efficacy. Psychol Health Med. 2023;28(4):1057\u201367.","journal-title":"Psychol Health Med"},{"issue":"1","key":"4020_CR30","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s10194-017-0779-1","volume":"18","author":"SH Lee","year":"2017","unstructured":"Lee SH, Kang Y, Cho SJ. Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality. J Headache Pain. 2017;18(1):77.","journal-title":"J Headache Pain"},{"issue":"6","key":"4020_CR31","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","volume":"10","author":"F Jessen","year":"2014","unstructured":"Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Ch\u00e9telat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer\u2019s disease. Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc. 2014;10(6):844\u201352.","journal-title":"Alzheimer\u2019s Dement J Alzheimer\u2019s Assoc"},{"issue":"1","key":"4020_CR32","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13195-022-01138-w","volume":"14","author":"MD Oliver","year":"2022","unstructured":"Oliver MD, Morrison C, Kamal F, Graham J, Dadar M. Subjective cognitive decline is a better marker for future cognitive decline in females than in males. Alzheimers Res Ther. 2022;14(1):197.","journal-title":"Alzheimers Res Ther"},{"key":"4020_CR33","doi-asserted-by":"publisher","first-page":"101232","DOI":"10.1016\/j.arr.2020.101232","volume":"66","author":"HM Gavelin","year":"2021","unstructured":"Gavelin HM, Dong C, Minkov R, Bahar-Fuchs A, Ellis KA, Lautenschlager NT, Mellow ML, Wade AT, Smith AE, Finke C, et al. Combined physical and cognitive training for older adults with and without cognitive impairment: a systematic review and network meta-analysis of randomized controlled trials. Ageing Res Rev. 2021;66:101232.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"4020_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11255-018-2000-0","volume":"51","author":"IM Abdulan","year":"2019","unstructured":"Abdulan IM, Onofriescu M, Stefaniu R, Mastaleru A, Mocanu V, Alexa ID, Covic A. The predictive value of malnutrition for functional and cognitive status in elderly hemodialysis patients. Int Urol Nephrol. 2019;51(1):155\u201362.","journal-title":"Int Urol Nephrol"},{"issue":"2","key":"4020_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.dsx.2017.09.003","volume":"12","author":"AAD Allawi","year":"2018","unstructured":"Allawi AAD. Malnutrition, inflamation and atherosclerosis (MIA syndrome) in patients with end stage renal disease on maintenance hemodialysis (a single centre experience). Diabetes Metabolic Syndrome. 2018;12(2):91\u20137.","journal-title":"Diabetes Metabolic Syndrome"},{"issue":"01","key":"4020_CR36","first-page":"90","volume":"21","author":"XC Yang","year":"2022","unstructured":"Yang XC, Zhu Y, Sun Q, Yu XP, Zhang X. New progress in the study of influencing factors, assessment and intervention of subjective cognitive decline. Diagnostics Theory Pract. 2022;21(01):90\u20134.","journal-title":"Diagnostics Theory Pract"},{"key":"4020_CR37","doi-asserted-by":"publisher","first-page":"625551","DOI":"10.3389\/fnagi.2021.625551","volume":"13","author":"M Cui","year":"2021","unstructured":"Cui M, Zhang S, Liu Y, Gang X, Wang G. Grip strength and the risk of Cognitive decline and Dementia: a systematic review and Meta-analysis of Longitudinal Cohort studies. Front Aging Neurosci. 2021;13:625551.","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"4020_CR38","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.mcna.2022.04.006","volume":"107","author":"CI Cohen","year":"2023","unstructured":"Cohen CI, Benyaminov R, Rahman M, Ngu D, Reinhardt M. Frailty: a Multidimensional Biopsychosocial Syndrome. Med Clin N Am. 2023;107(1):183\u201397.","journal-title":"Med Clin N Am"},{"issue":"10206","key":"4020_CR39","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","volume":"394","author":"EO Hoogendijk","year":"2019","unstructured":"Hoogendijk EO, Afilalo J, Ensrud KE, Kowal P, Onder G, Fried LP. Frailty: implications for clinical practice and public health. Lancet (London England). 2019;394(10206):1365\u201375.","journal-title":"Lancet (London England)"},{"issue":"1","key":"4020_CR40","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1080\/0886022X.2019.1628061","volume":"41","author":"C Garcia-Canton","year":"2019","unstructured":"Garcia-Canton C, Rodenas A, Lopez-Aperador C, Rivero Y, Anton G, Monzon T, Diaz N, Vega N, Loro JF, Santana A, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail. 2019;41(1):567\u201375.","journal-title":"Ren Fail"},{"issue":"9","key":"4020_CR41","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.1111\/jan.15676","volume":"79","author":"L Ye","year":"2023","unstructured":"Ye L, Tang X, Zhang H, Ge S, Yin L, Zhou Y, Chang J. Prevalence and risk factors of pre-frailty and frailty in maintenance haemodialysis patients in China: a cross-sectional study. J Adv Nurs. 2023;79(9):3522\u201334.","journal-title":"J Adv Nurs"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04020-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-025-04020-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04020-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:04:37Z","timestamp":1740369877000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-025-04020-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4020"],"URL":"https:\/\/doi.org\/10.1186\/s12882-025-04020-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4401518\/v1","asserted-by":"object"}]},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"10 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Medical Ethics Committee of West China Hospital of Sichuan University (approval number: 2022\u20131093) approved the study, and written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"92"}}