{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:57:49Z","timestamp":1783645069755,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Grants-in-aid from the Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-025-04032-3","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:12:01Z","timestamp":1741219921000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polycythemia secondary to bilaterally enlarged kidneys in T-Cell acute lymphoblastic leukemia: a case report and literature review"],"prefix":"10.1186","volume":"26","author":[{"given":"Koji","family":"Yoshimoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiro","family":"Maeoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiori","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Chishaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuji","family":"Mino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Ichinohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,6]]},"reference":[{"key":"4032_CR1","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","volume":"36","author":"R Alaggio","year":"2022","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, et al. The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36:1720\u201348.","journal-title":"Leukemia"},{"key":"4032_CR2","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1309\/AJCPMF03LVSBLHPJ","volume":"144","author":"MJ You","year":"2015","unstructured":"You MJ, Medeiros LJ, Hsi ED. T-lymphoblastic leukemia\/lymphoma. Am J Clin Pathol. 2015;144:411\u201322.","journal-title":"Am J Clin Pathol"},{"key":"4032_CR3","first-page":"163","volume":"42","author":"ML Malbrain","year":"1994","unstructured":"Malbrain ML, Lambrecht GL, Daelemans R, Lins RL, Hermans P, Zach\u00e9e P. Acute renal failure due to bilateral lymphomatous infiltrates. Primary extranodal non-Hodgkin\u2019s lymphoma (p-EN-NHL) of the kidneys: does it really exist? Clin Nephrol. 1994;42:163\u20139.","journal-title":"Clin Nephrol"},{"key":"4032_CR4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S0272-6386(87)80077-X","volume":"9","author":"LD Truong","year":"1987","unstructured":"Truong LD, Soroka S, Sheth AV, Kessler M, Mattioli C, Suki W. Primary renal lymphoma presenting as acute renal failure. Am J Kidney Dis. 1987;9:502\u20136.","journal-title":"Am J Kidney Dis"},{"key":"4032_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1681\/ASN.2004100843","volume":"16","author":"BD Humphreys","year":"2005","unstructured":"Humphreys BD, Soiffer RJ, Magee CC. Renal failure associated with cancer and its treatment: an update. J Am Soc Nephrol. 2005;16:151\u201361.","journal-title":"J Am Soc Nephrol"},{"key":"4032_CR6","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.ajkd.2003.08.004","volume":"42","author":"T T\u00f6rnroth","year":"2003","unstructured":"T\u00f6rnroth T, Heiro M, Marcussen N, Franssila K. Lymphomas diagnosed by percutaneous kidney biopsy. Am J Kidney Dis. 2003;42:960\u201371.","journal-title":"Am J Kidney Dis"},{"key":"4032_CR7","first-page":"109","volume":"21","author":"MMU Bhuiyan","year":"2020","unstructured":"Bhuiyan MMU, Bhowmic R, Siddiki MS, Patwari MKH, Biswas S. T-cell lymphoblastic leukaemia\/lymphoma presenting as bilateral renal enlargement and arthritis: a rare case report. J Med. 2020;21:109\u201312.","journal-title":"J Med"},{"key":"4032_CR8","first-page":"289","volume":"4","author":"AJ Kwakernaak","year":"2011","unstructured":"Kwakernaak AJ, Hazenberg MD, Roelofs JJ, van Noesel CJ, van Oers MH, van Tellingen A. Precursor T-lymphoblastic lymphoma presenting as primary renal lymphoma with acute renal failure. NDT Plus. 2011;4:289\u201391.","journal-title":"NDT Plus"},{"key":"4032_CR9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.5045\/kjh.2008.43.3.170","volume":"43","author":"HS Cho","year":"2008","unstructured":"Cho HS, Choi SO, Seol DC, Yoon HS, Jo Y-I, Lee HG. A case of acute lymphoblastic leukemia accompanied with lactic acidosis and kidney enlargement. Korean J Hematol. 2008;43:170.","journal-title":"Korean J Hematol"},{"key":"4032_CR10","doi-asserted-by":"publisher","first-page":"e28391","DOI":"10.1097\/MD.0000000000028391","volume":"100","author":"Y Tamura","year":"2021","unstructured":"Tamura Y, Sumiyoshi R, Yamamoto T, Hayama Y, Fujigaki Y, Shibata S, Sasajima Y, Tashiro H. Bilateral nephromegaly due to direct leukemic cell invasion in the initial and relapse phases of T-cell acute lymphoblastic leukaemia. Med (Baltim). 2021;100:e28391. 10.1097.","journal-title":"Med (Baltim)"},{"key":"4032_CR11","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1097\/HJH.0000000000001805","volume":"36","author":"P Krishnamoorthy","year":"2018","unstructured":"Krishnamoorthy P, Gopalakrishnan A, Mittal V, Kalla A, Slipczuk L, Rangaswami J, Figueredo VM, Messerli FH. Gaisb\u00f6ck syndrome (polycythemia and hypertension) revisited: results from the National inpatient sample database. J Hypertens. 2018;36:2420\u20134.","journal-title":"J Hypertens"},{"key":"4032_CR12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1007\/s11899-016-0334-1","volume":"11","author":"MF McMullin","year":"2016","unstructured":"McMullin MF. Investigation and management of erythrocytosis. Curr Hematol Malig Rep. 2016;11:342\u20137.","journal-title":"Curr Hematol Malig Rep"},{"key":"4032_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/0090-4295(83)90148-6","volume":"21","author":"I Hirsch","year":"1983","unstructured":"Hirsch I, Leiter E. Hydronephrosis and polycythemia. Urology. 1983;21:345\u201350.","journal-title":"Urology"},{"key":"4032_CR14","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1007\/s40620-021-01215-7","volume":"35","author":"J Fasolino","year":"2022","unstructured":"Fasolino J, Oklu R, Palmer J, Hommos MS. Polycythemia secondary to renal cysts. J Nephrol. 2022;35:1743\u20136.","journal-title":"J Nephrol"},{"key":"4032_CR15","doi-asserted-by":"publisher","first-page":"E163","DOI":"10.5489\/cuaj.1596","volume":"8","author":"M Blanc","year":"2014","unstructured":"Blanc M, Schmutz G, Belzile F, Sabbagh R. Renal lymphangiectasia presenting with hypertension and polycythemia. Can Urol Assoc J. 2014;8:E163\u20136.","journal-title":"Can Urol Assoc J"},{"key":"4032_CR16","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1200\/JCO.2005.03.3571","volume":"24","author":"AJ Al-Tourah","year":"2006","unstructured":"Al-Tourah AJ, Tsang PW, Skinnider BF, Hoskins PJ. Paraneoplastic erythropoietin-induced polycythemia associated with small lymphocytic lymphoma. J Clin Oncal. 2006;24:2388\u20139.","journal-title":"J Clin Oncal"},{"key":"4032_CR17","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s00431-013-2030-7","volume":"172","author":"T Osumi","year":"2013","unstructured":"Osumi T, Awazu M, Fujimura E, Yamazaki F, Hashiguchi A, Shimada H. Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway. Eur J Pediatr. 2013;172:829\u201332.","journal-title":"Eur J Pediatr"},{"key":"4032_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4103\/2277-9175.135417","volume":"3","author":"RA Bhat","year":"2014","unstructured":"Bhat RA, Khan I, Khan I, Mir MA. Polycythemia, increased erythropoietin levels in a patient with renal lymphoma. Adv Biomed Res. 2014;3:147.","journal-title":"Adv Biomed Res"},{"key":"4032_CR19","first-page":"100246","volume":"15","author":"K Vijayasekharan","year":"2021","unstructured":"Vijayasekharan K, Bhat KV, Venkatagiri AM, Godkhindi VM, Laxminarayana SLK, Belurkar S. Bilateral massive nephromegaly-A rare presentation of t-cell acute lymphoblastic leukemia. Leuk Res Rep. 2021;15:100246.","journal-title":"Leuk Res Rep"},{"key":"4032_CR20","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1053\/j.ackd.2013.07.004","volume":"21","author":"RL Luciano","year":"2014","unstructured":"Luciano RL, Brewster UC. Kidney involvement in leukemia and lymphoma. Adv Chronic Kidney Dis. 2014;21:27\u201335.","journal-title":"Adv Chronic Kidney Dis"},{"key":"4032_CR21","doi-asserted-by":"publisher","first-page":"342","DOI":"10.4103\/ijn.ijn_345_21","volume":"32","author":"S Nuguri","year":"2022","unstructured":"Nuguri S, Swain M, Padua M, Gowrishankar S. Renal lymphoma diagnosed on kidney biopsy presenting as acute kidney injury. Indian J Nephrol. 2022;32:342\u20137.","journal-title":"Indian J Nephrol"},{"key":"4032_CR22","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1038\/ki.1980.97","volume":"17","author":"CH Coggins","year":"1980","unstructured":"Coggins CH. Renal failure in lymphoma. Kidney Int. 1980;17:847\u201355. 10.1038.","journal-title":"Kidney Int"},{"key":"4032_CR23","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s13730-017-0261-6","volume":"6","author":"T Okubo","year":"2017","unstructured":"Okubo T, Hirashio S, Shimizu M, Kuroda Y, Doi S, Masaki T. Diffuse large B-cell lymphoma presenting as bilateral renal infiltration leading to acute kidney injury. CEN Case Rep. 2017;6:140\u20137.","journal-title":"CEN Case Rep"},{"key":"4032_CR24","doi-asserted-by":"publisher","first-page":"417","DOI":"10.12659\/AJCR.897904","volume":"17","author":"H Kitayama","year":"2016","unstructured":"Kitayama H, Kondo T, Sugiyama J, Hirayama M, Oyamada Y, Tsuji Y. Paraneoplastic erythrocytosis of Colon cancer, with serum erythropoietin within the normal reference range. Am J Case Rep. 2016;17:417\u201320.","journal-title":"Am J Case Rep"},{"key":"4032_CR25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1749-6632.1974.tb14452.x","volume":"230","author":"D Hammond","year":"1974","unstructured":"Hammond D, Winnick S. Paraneoplastic erythrocytosis and ectopic erythropoietins. Ann NY Acad Sci. 1974;230:219\u201327.","journal-title":"Ann NY Acad Sci"},{"key":"4032_CR26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/HJH.0000000000000029","volume":"32","author":"SY Jae","year":"2014","unstructured":"Jae SY, Kurl S, Laukkanen JA, Heffernan KS, Choo J, Choi YH, Park JB. Higher blood hematocrit predicts hypertension in men. J Hypertens. 2014;32:245\u201350.","journal-title":"J Hypertens"},{"key":"4032_CR27","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1161\/01.HYP.20.3.319","volume":"20","author":"M Cirillo","year":"1992","unstructured":"Cirillo M, Laurenzi M, Trevisan M, Stamler J. Hematocrit, blood pressure, and hypertension. The Gubbio population study. Hypertension. 1992;20:319\u201326.","journal-title":"Hypertension"},{"key":"4032_CR28","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3324\/haematol.2010.031070","volume":"96","author":"T Barbui","year":"2011","unstructured":"Barbui T, Carobbio A, Finazzi G, Vannucchi AM, Barosi G, Antonioli E, Guglielmelli P, Pancrazzi A, Salmoiraghi S, Zilio P, Ottomano C, Marchioli R, Cuccovillo I, Bottazzi B, Mantovani A, Rambaldi A. AGIMM and IIC investigators. Inflammation and thrombosis in essential thrombocythemia and polycythemia Vera: different role of C-reactive protein and pentraxin 3. Haematologica. 2011;96:315\u20138.","journal-title":"Haematologica"},{"key":"4032_CR29","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1161\/01.HYP.31.3.848","volume":"31","author":"G Bertinieri","year":"1998","unstructured":"Bertinieri G, Parati G, Ulian L, Santucciu C, Massaro P, Cosentini R, Torgano G, Morganti A, Mancia G. Hemodilution reduces clinic and ambulatory blood pressure in polycythemic patients. Hypertension. 1998;31:848\u201353.","journal-title":"Hypertension"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04032-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-025-04032-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04032-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T11:55:30Z","timestamp":1741262130000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/s12882-025-04032-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4032"],"URL":"https:\/\/doi.org\/10.1186\/s12882-025-04032-3","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,6]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted according to the guidelines in the Declaration of Helsinki. Informed consent was obtained from the patient; the consent allowed their data to be stored, as required by Hiroshima University Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"121"}}