{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:29:12Z","timestamp":1787020152941,"version":"build-2736575974"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease-associated pruritus (CKD-aP) is a common and bothersome symptom among hemodialysis (HD) patients. This study aimed to determine the association of Energy-adjusted dietary inflammatory index (E-DII) index with the risk and severity of CKD-aP in hemodialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study was conducted on 200 HD patients. A valid 168-item semi-quantitative Food Frequency Questionnaire (FFQ) was used to assess the usual food intake and calculated E-DII. Yosipovitch Itch Questionnaire was used to assess CKD-aP. Based on the E- DII score, odds ratios, and 95% confidence intervals were calculated for the risk of CKD-aP. Generalized linear models (GLM) was used to determine the association between E-DII scores and CKD-aP score, and pruritus Visual Analogue Scale (VAS) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The continuous E-DII score was associated with an increased risk of CKD-aP in all three models: model 1, OR\u2009=\u20091.19 (95% CI: 1.02\u20131.40); model 2, OR\u2009=\u20091.29 (1.01\u20131.65); and model 3, OR\u2009=\u20091.41 (1.01\u20131.98). Moreover, linear regression analysis showed statistically significant associations (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) between the E-DII score and both CKD-aP and VAS scores across all three models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides evidence that higher consumption of a pro-inflammatory diet is associated with an increased risk of CKD-aP in HD patients. Future studies with prospective and interventional designs are required to clarify the association between this dietary index and CKD-aP in HD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-025-04211-2","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T08:08:00Z","timestamp":1751357280000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Energy-adjusted dietary inflammatory index is associated with chronic kidney disease-associated pruritus in Hemodialysis patients: a cross-sectional study"],"prefix":"10.1186","volume":"26","author":[{"given":"Hosein","family":"Rostami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Delkhosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"issue":"2","key":"4211_CR1","first-page":"161","volume":"21","author":"I Narita","year":"2008","unstructured":"Narita I, Iguchi S, Omori K, Gejyo F. 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Patients were included in the study after face-to-face oral explanation about the objectives and methodology of the research and obtaining informed consent. The research units were explained about the confidentiality of the collected information and the voluntary participation in the study, the freedom to leave the study whenever they want. All methods were performed in accordance with the relevant guidelines and regulations, which are aligned with the Declaration. Consent for publication Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"324"}}