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Here we describe the epidemiology, clinical features, treatment and outcomes in patients, over the age of 16 years, with kidney biopsy proven cases seen in two regions of Aotearoa, New Zealand over an 18-year period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Potential cases were identified, in patients over the age of 16 years, who underwent kidney biopsy between 2003 and 2020. A retrospective review of all potential cases was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Thirty-four patients were identified, 10 females and 24 males, of whom 15 were European, 5 M\u0101ori, 7 Pacific Peoples, and 7 Asians. The incidence was 1.16 per 1,000,000 patient-years (95% CI: 0.82\u20131.61), there was an excess in males (RR\u2009=\u20092.42 95% CI 1.16\u20135.06, <jats:italic>p\u2009=<\/jats:italic>\u20090.016) with no excess by ethnicity. Mean age at presentation was 42.8 years (range 16.4\u201370.5). Mean creatinine at presentation was 118\u00b5mol\/L (range 51\u2013410). Twenty-six patents received corticosteroids, with two patients also receiving cyclophosphamide and five patients receiving azathioprine. Six patients (17.6%) needed long-term kidney replacement therapy, 12 were left with significant chronic kidney disease (35.3%) and 4 died (11.8%) at the end of study follow up. Elevated serum creatinine at presentation was predictive of need for kidney replacement therapy. Age was predictive of mortality.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Immunoglobulin A vasculitis is not overrepresented among indigenous people in Aotearoa New Zealand. The majority of patients receive immunosuppression, however, were left with significant kidney disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s12882-025-04362-2","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T20:55:48Z","timestamp":1753995348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, clinical features and outcomes of patients with kidney biopsy proven IgA vasculitis in Auckland and Northland, Aotearoa, New Zealand presenting between 2003\u20132020."],"prefix":"10.1186","volume":"26","author":[{"given":"Janak Rashme","family":"de Zoysa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"4362_CR1","doi-asserted-by":"publisher","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. 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As this was a retrospective study a waiver for the need for patient consent was granted by the Auckland Health Research Ethics Committee and the Waitemat\u0101 M\u0101ori Health Research committee as there is no identifiable information. Administrative authorisation for data collection was granted by appropriate authorities and conducted following the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"A consent for publication is not required by either the Auckland Health Research Ethics Committee nor the Waitemat\u0101 M\u0101ori Health Research committee. There are no identifying images, other personal nor clinical details of participants presented that compromise anonymity.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"426"}}