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As the disease progresses, patients often experience a significant decline in quality of life (QoL), driven by disease-related symptoms and the burden of renal replacement therapies (RRT) such as dialysis and transplantation. In addition to physical symptoms, up to 55% of patients report psychological distress, including depression and anxiety. Despite this, mental health needs are frequently under-identified and insufficiently addressed in nephrology care. There is limited understanding of how patients experience and cope with this distress, how staff perceive their role in responding to it, and how healthcare environments support or hinder psychosocial care. This study seeks to address these gaps within a single integrated nephrology care network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This explanatory sequential mixed-methods study will be conducted in two phases. In the first phase, quantitative data will be collected from 200 patients with CKD and 40\u201350 nephrology staff members using validated questionnaires assessing psychological distress, anxiety, depression, and QoL. Group comparisons will assess differences across RRT modalities, and association analyses will explore relationships between psychological outcomes and demographic or clinical factors. In the second phase, semi-structured interviews and focus groups with patients and staff will explore experiences of psychological distress and care delivery in greater depth. Thematic analysis will be used for qualitative data. Integration of findings through triangulation will provide a comprehensive understanding of psychosocial needs and inform intervention development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study uses a mixed-methods design to investigate psychosocial needs in CKD care from both patient and provider perspectives. It aims to identify modifiable clinical and organizational factors\u2014such as staff preparedness, referral practices, and systemic barriers\u2014that shape the delivery of mental health support. Findings will inform the development of person-centered interventions and may guide broader models for integrating psychological care into chronic disease management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Status of trial<\/jats:title>\n                    <jats:p>The study began in June 2024. Participant recruitment and data collection are ongoing and will continue until June 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Number<\/jats:title>\n                    <jats:p>Not applicable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-025-04563-9","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:48:06Z","timestamp":1763462886000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A mixed-methods protocol to explore psychological distress and psychosocial needs along the continuum of CKD care\u2014 a single healthcare network"],"prefix":"10.1186","volume":"26","author":[{"given":"Mathilde","family":"Par\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norah","family":"Zola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00ebtitia","family":"Coudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien-Carl","family":"Phaneuf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne","family":"Lavall\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Caplette-Gingras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Agharazii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"4563_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-981-13-8871-2_1","volume":"1165","author":"JC Lv","year":"2019","unstructured":"Lv JC, Zhang LX. 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