{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:13:43Z","timestamp":1790914423271,"version":"4.1.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsmedizin Rostock"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemoadsorption has emerged as a promising adjunctive therapy in the management of various inflammatory and toxin-mediated conditions. Its role in context of rhabdomyolysis has generated increasing scientific and clinical interest. In response to the recent consensus statement by an international expert task force\u2014published in BMC Nephrology in July 2024\u2014regarding the use of hemoadsorption in rhabdomyolysis, we aim to contribute further to this evolving discourse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report on a patient with severe rhabdomyolysis secondary to influenza B infection who suffered acute kidney injury (AKI) as a result. Alongside conservative treatment, we successfully implemented a combined regimen of CRRT and hemoadsorption, while using myoglobin levels up- and downstream of the adsorber as a tool for therapy monitoring. The patient subsequently recovered complete renal function and full body mobility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The case illustrates the practical implementation of hemoadsorption within a multimodal treatment strategy. In addition to demonstrating concordance with current consensus guidelines, we seek to critically discuss potential refinements in the therapeutic approach\u2014particularly concerning monitoring strategies and the integration of extracorporeal modalities\u2014to facilitate future clinical practice and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12882-025-04590-6","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T11:39:40Z","timestamp":1763638780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Insights on the practical application of the current treatment consensus in rhabdomyolysis management: a case report"],"prefix":"10.1186","volume":"26","author":[{"given":"Theresa","family":"Gier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Koball","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Marcello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faeq","family":"Husain-Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Ram\u00edrez-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Mitzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens-Christian","family":"Schewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Reuter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Klinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"4590_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1186\/s12882-024-03679-8","volume":"25","author":"L Forni","year":"2024","unstructured":"Forni L, Aucella F, Bottari G, B\u00fcttner S, Cantaluppi V, Fries D, et al. Hemoadsorption therapy for myoglobin removal in rhabdomyolysis: consensus of the hemoadsorption in rhabdomyolysis task force. BMC Nephrol. 2024;25:247. https:\/\/doi.org\/10.1186\/s12882-024-03679-8.","journal-title":"BMC Nephrol"},{"key":"4590_CR2","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1186\/s13054-020-03366-8","volume":"24","author":"L Weidhase","year":"2020","unstructured":"Weidhase L, de Fallois J, Hau\u00dfig E, Kaiser T, Mende M, Petros S. Myoglobin clearance with continuous veno-venous Hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled trial. Crit Care. 2020;24:644. https:\/\/doi.org\/10.1186\/s13054-020-03366-8.","journal-title":"Crit Care"},{"key":"4590_CR3","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1159\/000505899","volume":"49","author":"O Dilken","year":"2020","unstructured":"Dilken O, Ince C, van der Hoven B, Thijsse S, Ormskerk P, de Geus HRH. Successful reduction of creatine kinase and myoglobin levels in severe rhabdomyolysis using extracorporeal blood purification (CytoSorb\u00ae). Blood Purif. 2020;49:743\u20137. https:\/\/doi.org\/10.1159\/000505899.","journal-title":"Blood Purif"},{"key":"4590_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/1744-9987.12410","volume":"20","author":"S Suefke","year":"2016","unstructured":"Suefke S, Sayk F, Nitschke M. Hemoadsorption in Infection-Associated rhabdomyolysis. Ther Apher Dial. 2016;20:531\u20133. https:\/\/doi.org\/10.1111\/1744-9987.12410.","journal-title":"Ther Apher Dial"},{"key":"4590_CR5","doi-asserted-by":"publisher","first-page":"300060525133790","DOI":"10.1177\/03000605251337905","volume":"53","author":"X Zhou","year":"2025","unstructured":"Zhou X, Li X, Yang Y, Wang F, Zhang L, Fu P. Hemoadsorption combined with continuous venovenous hemodialyfiltration in a patient with Escherichia coli infection and severe diabetic ketoacidosis-associated rhabdomyolysis: A case report. J Int Med Res. 2025;53:3000605251337905. https:\/\/doi.org\/10.1177\/03000605251337905.","journal-title":"J Int Med Res"},{"key":"4590_CR6","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/03913988251339080","volume":"48","author":"M Pieri","year":"2025","unstructured":"Pieri M, Russo G, Francescon C, Fominskiy E, Nardelli P, Calabr\u00f2 MG, et al. Dual concomitant cytosorb hemoadsorption therapy in severe rhabdomyolysis: A novel approach to myoglobin clearance and organ preservation. Int J Artif Organs. 2025;48:429\u201333. https:\/\/doi.org\/10.1177\/03913988251339080.","journal-title":"Int J Artif Organs"},{"key":"4590_CR7","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1159\/000508277","volume":"50","author":"HC Daum","year":"2021","unstructured":"Daum HC, Schmidt BMW, Napp LC. Effects of hemoadsorption with cytosorb during severe rhabdomyolysis. Blood Purif. 2021;50:268\u20139. https:\/\/doi.org\/10.1159\/000508277.","journal-title":"Blood Purif"},{"key":"4590_CR8","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jcrc.2021.04.011","volume":"64","author":"P Schultz","year":"2021","unstructured":"Schultz P, Schwier E, Eickmeyer C, Henzler D, K\u00f6hler T. High-dose cytosorb hemoadsorption is associated with improved survival in patients with septic shock: A retrospective cohort study. J Crit Care. 2021;64:184\u201392. https:\/\/doi.org\/10.1016\/j.jcrc.2021.04.011.","journal-title":"J Crit Care"},{"key":"4590_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1097\/CCM.0000000000002769","volume":"46","author":"MK Luther","year":"2018","unstructured":"Luther MK, Timbrook TT, Caffrey AR, Dosa D, Lodise TP, LaPlante KL. Vancomycin plus Piperacillin-Tazobactam and acute kidney injury in adults: A systematic review and Meta-Analysis. Crit Care Med. 2018;46:12\u201320. https:\/\/doi.org\/10.1097\/CCM.0000000000002769.","journal-title":"Crit Care Med"},{"key":"4590_CR10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3109\/08860229709026290","volume":"19","author":"E Homsi","year":"1997","unstructured":"Homsi E, Barreiro MF, Orlando JM, Higa EM. Prophylaxis of acute renal failure in patients with rhabdomyolysis. Ren Fail. 1997;19:283\u20138. https:\/\/doi.org\/10.3109\/08860229709026290.","journal-title":"Ren Fail"},{"key":"4590_CR11","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1097\/01.ta.0000130761.78627.10","volume":"56","author":"CVR Brown","year":"2004","unstructured":"Brown CVR, Rhee P, Chan L, Evans K, Demetriades D, Velmahos GC. Preventing renal failure in patients with rhabdomyolysis: do bicarbonate and mannitol make a difference? J Trauma. 2004;56:1191\u20136. https:\/\/doi.org\/10.1097\/01.ta.0000130761.78627.10.","journal-title":"J Trauma"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04590-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-025-04590-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-025-04590-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:15:24Z","timestamp":1781615724000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12882-025-04590-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4590"],"URL":"https:\/\/doi.org\/10.1186\/s12882-025-04590-6","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]},"assertion":[{"value":"27 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written consent for publication of clinical details has been obtained from the patient and the parental guardian prior to submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"T.R. has received funding for lectures and has been consultant or advisory board member for Alexion, AstraZeneca, B. Braun, Baxter, bioM\u00e9rieux, Boehringer Ingelheim, Contatti (CytoSorbents), Eurofarma, George Clinical, Jafron, Lifepharma, Medcorp, Nipro, and Nova Biomedical; S. M. is shareholder of Artcline GmbH and received funding for lectures and has been consultant or advisory board member Cytosorbents Europe GmbH; C.R. has been on advisory boards or speaker\u2019s bureau for AstraZeneca, Aferetica, Asahi, B. Braun, Baxter, bioM\u00e9rieux, CytoSorbents, GE, Medica, Medtronic, and Jafron; G.K. has received funding for lectures for Artcline GmbH and Cytosorbents Europe GmbH and has received research grants from the German Society of Anaesthesiology and Intensive Care.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"657"}}