{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:59Z","timestamp":1777984259628,"version":"3.51.4"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"DOI":"10.1186\/s12882-026-04887-0","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:45:18Z","timestamp":1773924318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemoglobinuria-associated acute kidney injury in hemolytic uremic syndrome without renal thrombotic microangiopathy"],"prefix":"10.1186","volume":"27","author":[{"given":"Nicoletta","family":"Mancianti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jingjing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Antonio","family":"Tripodi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Garosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"issue":"7","key":"4887_CR1","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1056\/NEJMra1312353","volume":"371","author":"JN George","year":"2014","unstructured":"George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med. 2014;371(7):654\u201366.","journal-title":"N Engl J Med"},{"issue":"4","key":"4887_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00281-014-0416-x","volume":"36","author":"C Mele","year":"2014","unstructured":"Mele C, Remuzzi G, Noris M. Hemolytic uremic syndrome. Semin Immunopathol. 2014;36(4):399\u2013420.","journal-title":"Semin Immunopathol"},{"key":"4887_CR3","first-page":"76","volume":"9","author":"M Shrivastava","year":"2016","unstructured":"Shrivastava M, Shah N. Pregnancy Associated Thrombotic Microangiopathy. People\u2019s J Sci Res. 2016;9:76\u201386.","journal-title":"People\u2019s J Sci Res"},{"key":"4887_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ki.1995.261","volume":"48","author":"G Remuzzi","year":"1995","unstructured":"Remuzzi G, Ruggenenti P. The hemolytic uremic syndrome. Kidney Int. 1995;48:2\u201319.","journal-title":"Kidney Int"},{"issue":"3","key":"4887_CR5","first-page":"840","volume":"17","author":"J Caprioli","year":"2006","unstructured":"Caprioli J, Noris M, Brioschi S, et al. Genetics of HUS: the impact of complement factor H mutations. J Am Soc Nephrol. 2006;17(3):840\u20137.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"4887_CR6","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2215\/CJN.04760512","volume":"8","author":"V Fremeaux-Bacchi","year":"2013","unstructured":"Fremeaux-Bacchi V, Fakhouri F, Garnier A, et al. Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults. Clin J Am Soc Nephrol. 2013;8(4):554\u201362.","journal-title":"Clin J Am Soc Nephrol"},{"key":"4887_CR7","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1056\/NEJMra0902814","volume":"361","author":"M Noris","year":"2009","unstructured":"Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009;361:1676\u201387.","journal-title":"N Engl J Med"},{"issue":"1","key":"4887_CR8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1681\/ASN.2013050453","volume":"25","author":"F Bu","year":"2014","unstructured":"Bu F, Maga T, Meyer NC, et al. Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2014;25(1):55\u201364.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"4887_CR9","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1681\/ASN.2004050380","volume":"16","author":"MA Dragon-Durey","year":"2005","unstructured":"Dragon-Durey MA, Loirat C, Cloarec S, et al. Anti\u2013factor H autoantibodies associated with atypical hemolytic uremic syndrome. J Am Soc Nephrol. 2005;16(2):555\u201363.","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"4887_CR10","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.2215\/CJN.02210310","volume":"5","author":"M Noris","year":"2010","unstructured":"Noris M, Remuzzi G. Atypical hemolytic uremic syndrome: from bench to bedside. Clin J Am Soc Nephrol. 2010;5(10):1844\u201359.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"4887_CR11","doi-asserted-by":"crossref","first-page":"152575","DOI":"10.1016\/j.prp.2019.152575","volume":"215","author":"Z Dvanajscak","year":"2019","unstructured":"Dvanajscak Z, Walker PD, Cossey LN, Messias NC, Boils CL, Larsen CP. Hemolysis-associated hemoglobin cast nephropathy: clinicopathologic characterization of 27 cases. Pathol Res Pract. 2019;215(10):152575.","journal-title":"Pathol Res Pract"},{"issue":"9","key":"4887_CR12","first-page":"1476","volume":"5","author":"S Mahmud","year":"2020","unstructured":"Mahmud S, Muci\u00f1o-Bermejo J, Hidalgo J, et al. Hemoglobin cast nephropathy: clinical features and outcomes. Kidney Int Rep. 2020;5(9):1476\u201380.","journal-title":"Kidney Int Rep"},{"issue":"4","key":"4887_CR13","first-page":"e58472","volume":"16","author":"PS Patel","year":"2024","unstructured":"Patel PS, Singh S, Goel P, et al. Pigment-induced acute kidney injury: a case series and review. Cureus. 2024;16(4):e58472.","journal-title":"Cureus"},{"issue":"10","key":"4887_CR14","first-page":"1420","volume":"9","author":"O Pourrat","year":"1994","unstructured":"Pourrat O, Deray G, Isnard H, et al. Adult hemolytic uremic syndrome: six cases without renal TMA on biopsy. Nephrol Dial Transpl. 1994;9(10):1420\u20133.","journal-title":"Nephrol Dial Transpl"},{"key":"4887_CR15","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/ijlh.12059","volume":"35","author":"HJ Huh","year":"2013","unstructured":"Huh HJ, Chung JW, Chae SL. Microscopic schistocyte determination according to International Council for Standardization in Hematology recommendations in various diseases. Int J Lab Hematol. 2013;35:542\u20137.","journal-title":"Int J Lab Hematol"},{"issue":"1","key":"4887_CR16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4274\/tjh.2016.0359","volume":"34","author":"E Schapkaitz","year":"2017","unstructured":"Schapkaitz E, Mezgebe MH. The clinical significance of schistocytes: a prospective evaluation of the International Council for Standardization in Hematology schistocyte guidelines. Turk J Haematol. 2017;34(1):59\u201363.","journal-title":"Turk J Haematol"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12882-026-04887-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-026-04887-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12882-026-04887-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:53:29Z","timestamp":1777341209000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12882-026-04887-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,19]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4887"],"URL":"https:\/\/doi.org\/10.1186\/s12882-026-04887-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8155876\/v1","asserted-by":"object"}]},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,19]]},"assertion":[{"value":"19 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent for publication of the clinical details and any accompanying images was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"265"}}