{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:12:03Z","timestamp":1771539123941,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/s12883-014-0232-x","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T19:01:17Z","timestamp":1418151677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["An open-label pilot trial of minocycline in children as a treatment for Angelman syndrome"],"prefix":"10.1186","volume":"14","author":[{"given":"Joseph C","family":"Grieco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Ciarlone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gieron-Korthals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike R","family":"Schoenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda G","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rex M","family":"Philpot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen S","family":"Heussler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L","family":"Banko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin J","family":"Weeber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"issue":"6","key":"232_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/j.1469-8749.1965.tb07844.x","volume":"7","author":"H Angelman","year":"1965","unstructured":"Angelman H: \u2018Puppet\u2019 children a report on three cases. Dev Med Child Neurol. 1965, 7 (6): 681-688. 10.1111\/j.1469-8749.1965.tb07844.x.","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"232_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1002\/ajmg.a.30154","volume":"132A","author":"RJ Barry","year":"2005","unstructured":"Barry RJ, Leitner RP, Clarke AR, Einfeld SL: Behavioral aspects of Angelman syndrome: a case control study. Am J Med Genet A. 2005, 132A (1): 8-12. 10.1002\/ajmg.a.30154.","journal-title":"Am J Med Genet A"},{"issue":"2","key":"232_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.braindev.2003.09.014","volume":"27","author":"CA Williams","year":"2005","unstructured":"Williams CA: Neurological aspects of the Angelman syndrome. Brain Dev. 2005, 27 (2): 88-94. 10.1016\/j.braindev.2003.09.014.","journal-title":"Brain Dev"},{"issue":"Pt 1","key":"232_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1365-2788.2005.00730.x","volume":"50","author":"K Horsler","year":"2006","unstructured":"Horsler K, Oliver C: The behavioural phenotype of Angelman syndrome. J Intellect Disabil Res. 2006, 50 (Pt 1): 33-53. 10.1111\/j.1365-2788.2005.00730.x.","journal-title":"J Intellect Disabil Res"},{"issue":"4","key":"232_CR5","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/ajmg.c.30278","volume":"154C","author":"CA Williams","year":"2010","unstructured":"Williams CA: The behavioral phenotype of the Angelman syndrome. Am J Med Genet C: Semin Med Genet. 2010, 154C (4): 432-437. 10.1002\/ajmg.c.30278.","journal-title":"Am J Med Genet C: Semin Med Genet"},{"issue":"3","key":"232_CR6","first-page":"577","volume":"4","author":"K Pelc","year":"2008","unstructured":"Pelc K, Cheron G, Dan B: Behavior and neuropsychiatric manifestations in Angelman syndrome. Neuropsychiatr Dis Treat. 2008, 4 (3): 577-","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"2","key":"232_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1136\/jmg.40.2.87","volume":"40","author":"J Clayton-Smith","year":"2003","unstructured":"Clayton-Smith J, Laan L: Angelman syndrome: a review of the clinical and genetic aspects. J Med Genet. 2003, 40 (2): 87-95. 10.1136\/jmg.40.2.87.","journal-title":"J Med Genet"},{"issue":"5","key":"232_CR8","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1007\/BF00441976","volume":"147","author":"SG Boyd","year":"1988","unstructured":"Boyd SG, Harden A, Patton MA: The EEG in early diagnosis of the Angelman (happy puppet) syndrome. Eur J Pediatr. 1988, 147 (5): 508-513. 10.1007\/BF00441976.","journal-title":"Eur J Pediatr"},{"issue":"2","key":"232_CR9","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1528-1157.1997.tb01097.x","volume":"38","author":"LA Laan","year":"1997","unstructured":"Laan LA, Renier WO, Arts WF, Buntinx IM, Vd Burgt IJ, Stroink H, Beuten J, Zwinderman KH, van Dijk JG, Brouwer OF: Evolution of epilepsy and EEG findings in Angelman syndrome. Epilepsia. 1997, 38 (2): 195-199. 10.1111\/j.1528-1157.1997.tb01097.x.","journal-title":"Epilepsia"},{"issue":"2","key":"232_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.braindev.2003.09.013","volume":"27","author":"LA Laan","year":"2005","unstructured":"Laan LA, Vein AA: Angelman syndrome: is there a characteristic EEG?. Brain Dev. 2005, 27 (2): 80-87. 10.1016\/j.braindev.2003.09.013.","journal-title":"Brain Dev"},{"issue":"3","key":"232_CR11","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.yebeh.2011.11.027","volume":"23","author":"M Vendrame","year":"2012","unstructured":"Vendrame M, Loddenkemper T, Zarowski M, Gregas M, Shuhaiber H, Sarco DP, Morales A, Nespeca M, Sharpe C, Haas K, Barnes G, Glaze D, Kothare SV: Analysis of EEG patterns and genotypes in patients with Angelman syndrome. Epilepsy Behav. 2012, 23 (3): 261-265. 10.1016\/j.yebeh.2011.11.027.","journal-title":"Epilepsy Behav"},{"issue":"3","key":"232_CR12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.seizure.2007.08.004","volume":"17","author":"K Pelc","year":"2008","unstructured":"Pelc K, Boyd SG, Cheron G, Dan B: Epilepsy in Angelman syndrome. Seizure. 2008, 17 (3): 211-217. 10.1016\/j.seizure.2007.08.004.","journal-title":"Seizure"},{"issue":"7","key":"232_CR13","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1177\/0883073809332767","volume":"24","author":"C Williams","year":"2009","unstructured":"Williams C: Angelman syndrome scientific symposium on the structure and function of UBE3A\/E6AP. J Child Neurol. 2009, 24 (7): 904-908. 10.1177\/0883073809332767.","journal-title":"J Child Neurol"},{"issue":"1","key":"232_CR14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/ng0197-70","volume":"15","author":"T Kishino","year":"1997","unstructured":"Kishino T, Lalande M, Wagstaff J: UBE3A\/E6-AP mutations cause Angelman syndrome. Nat Genet. 1997, 15 (1): 70-73. 10.1038\/ng0197-70.","journal-title":"Nat Genet"},{"issue":"3","key":"232_CR15","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2010.09.038","volume":"143","author":"SS Margolis","year":"2010","unstructured":"Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME: EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. Cell. 2010, 143 (3): 442-455. 10.1016\/j.cell.2010.09.038.","journal-title":"Cell"},{"issue":"1","key":"232_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1093\/hmg\/ddm288","volume":"17","author":"SV Dindot","year":"2008","unstructured":"Dindot SV, Antalffy BA, Bhattacharjee MB, Beaudet AL: The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Hum Mol Genet. 2008, 17 (1): 111-118. 10.1093\/hmg\/ddm288.","journal-title":"Hum Mol Genet"},{"issue":"9","key":"232_CR17","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1101\/lm.2153511","volume":"18","author":"JT Rogers","year":"2011","unstructured":"Rogers JT, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak DT, Babus LW, Peters M, Banko JL, Chavis P: Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 2011, 18 (9): 558-564. 10.1101\/lm.2153511.","journal-title":"Learn Mem"},{"issue":"12","key":"232_CR18","doi-asserted-by":"publisher","first-page":"e27221","DOI":"10.1371\/journal.pone.0027221","volume":"6","author":"JL Daily","year":"2011","unstructured":"Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ: Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PLoS One. 2011, 6 (12): e27221-10.1371\/journal.pone.0027221.","journal-title":"PLoS One"},{"issue":"7380","key":"232_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature10726","volume":"481","author":"H-S Huang","year":"2012","unstructured":"Huang H-S, Allen JA, Mabb AM, King IF, Miriyala J, Taylor-Blake B, Sciaky N, Dutton JW, Lee H-M, Chen X: Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature. 2012, 481 (7380): 185-189. 10.1038\/nature10726.","journal-title":"Nature"},{"issue":"3","key":"232_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/nn1845","volume":"10","author":"GM Van Woerden","year":"2007","unstructured":"Van Woerden GM, Harris KD, Hojjati MR, Gustin RM, Qiu S, de Avila FR, Jiang Y-h, Elgersma Y, Weeber EJ: Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of \u03b1CaMKII inhibitory phosphorylation. Nat Neurosci. 2007, 10 (3): 280-282. 10.1038\/nn1845.","journal-title":"Nat Neurosci"},{"issue":"2","key":"232_CR21","doi-asserted-by":"publisher","first-page":"123","DOI":"10.2174\/157489011795933783","volume":"6","author":"BO Ulgen","year":"2011","unstructured":"Ulgen BO, Field MG, Qureshi W, Knight RA, Stephanou A, Latchman DS, Vasquez D, Barry SP, Saravolatz L, Scarabelli GM, Faggian G, Mazzucco A, Saravolatz L, Chen-Scarabelli C, Scarabelli TM: The role of minocycline in ischemia-reperfusion injury: a comprehensive review of an old drug with new implications. Recent Pat Cardiovasc Drug Discov. 2011, 6 (2): 123-132. 10.2174\/157489011795933783.","journal-title":"Recent Pat Cardiovasc Drug Discov"},{"issue":"5","key":"232_CR22","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1002\/cpt1973145852","volume":"14","author":"H Macdonald","year":"1973","unstructured":"Macdonald H, Kelly RG, Allen ES, Noble JF, Kanegis LA: Pharmacokinetic studies on minocycline in man. Clin Pharmacol Ther. 1973, 14 (5): 852-861.","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"232_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1136\/jmg.2008.061796","volume":"46","author":"TV Bilousova","year":"2009","unstructured":"Bilousova TV, Dansie L, Ngo M, Aye J, Charles JR, Ethell DW, Ethell IM: Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet. 2009, 46 (2): 94-102. 10.1136\/jmg.2008.061796.","journal-title":"J Med Genet"},{"key":"232_CR24","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2147\/OPTH.S11216","volume":"4","author":"M Kernt","year":"2010","unstructured":"Kernt M, Neubauer AS, Eibl KH, Wolf A, Ulbig MW, Kampik A, Hirneiss C: Minocycline is cytoprotective in human trabecular meshwork cells and optic nerve head astrocytes by increasing expression of XIAP, survivin, and Bcl-2. Clin Ophthalmol (Auckland, NZ). 2010, 4: 591-10.2147\/OPTH.S11216.","journal-title":"Clin Ophthalmol (Auckland, NZ)"},{"issue":"1","key":"232_CR25","first-page":"21","volume":"28","author":"S Mehrotra","year":"2014","unstructured":"Mehrotra S, Pecaut MJ, Gridley DS: Minocycline modulates cytokine and gene expression profiles in the brain after whole-body exposure to radiation. In vivo. 2014, 28 (1): 21-32.","journal-title":"In vivo"},{"issue":"3","key":"232_CR26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrn1346","volume":"5","author":"GM Thomas","year":"2004","unstructured":"Thomas GM, Huganir RL: MAPK cascade signalling and synaptic plasticity. Nat Rev Neurosci. 2004, 5 (3): 173-183. 10.1038\/nrn1346.","journal-title":"Nat Rev Neurosci"},{"issue":"3\u20134","key":"232_CR27","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1159\/000336773","volume":"89","author":"LJ Jin","year":"2012","unstructured":"Jin LJ, Schlesinger F, Guan Q, Song YP, Nie ZY: The two different effects of the potential neuroprotective compound minocycline on AMPA-type glutamate receptors. Pharmacology. 2012, 89 (3\u20134): 156-162. 10.1159\/000336773.","journal-title":"Pharmacology"},{"issue":"7\u20138","key":"232_CR28","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.neuropharm.2010.09.006","volume":"60","author":"H Chen","year":"2011","unstructured":"Chen H, Manev H: Effects of minocycline on cocaine sensitization and phosphorylation of GluR1 receptors in 5-lipoxygenase deficient mice. Neuropharmacology. 2011, 60 (7\u20138): 1058-1063. 10.1016\/j.neuropharm.2010.09.006.","journal-title":"Neuropharmacology"},{"issue":"5\u20136","key":"232_CR29","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3109\/17482960802702288","volume":"10","author":"H Manev","year":"2009","unstructured":"Manev H, Manev R: Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS. Amyotroph Lateral Scler. 2009, 10 (5\u20136): 416-417. 10.3109\/17482960802702288.","journal-title":"Amyotroph Lateral Scler"},{"issue":"2","key":"232_CR30","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.expneurol.2004.10.010","volume":"191","author":"B Goni-Allo","year":"2005","unstructured":"Goni-Allo B, Ramos M, Jord\u00e1n J, Aguirre N: In vivo studies on the protective role of minocycline against excitotoxicity caused by malonate or N\u2212methyl-D-aspartate. Exp Neurol. 2005, 191 (2): 326-330. 10.1016\/j.expneurol.2004.10.010.","journal-title":"Exp Neurol"},{"issue":"5","key":"232_CR31","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.cell.2010.01.026","volume":"140","author":"PL Greer","year":"2010","unstructured":"Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim T-K, Griffith EC, Waldon Z, Maehr R: The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 2010, 140 (5): 704-716. 10.1016\/j.cell.2010.01.026.","journal-title":"Cell"},{"issue":"2","key":"232_CR32","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.pnpbp.2007.08.031","volume":"32","author":"Y Fujita","year":"2008","unstructured":"Fujita Y, Ishima T, Kunitachi S, Hagiwara H, Zhang L, Iyo M, Hashimoto K: Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline. Prog Neuro-Psychopharmacol Biol Psychiatry. 2008, 32 (2): 336-339. 10.1016\/j.pnpbp.2007.08.031.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"13","key":"232_CR33","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1523\/JNEUROSCI.1846-13.2014","volume":"34","author":"M Pignatelli","year":"2014","unstructured":"Pignatelli M, Piccinin S, Molinaro G, Di Menna L, Riozzi B, Cannella M, Motolese M, Vetere G, Catania MV, Battaglia G: Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome. The Journal of neuroscience. 2014, 34 (13): 4558-4566. 10.1523\/JNEUROSCI.1846-13.2014.","journal-title":"The Journal of neuroscience"},{"issue":"7","key":"232_CR34","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1523\/JNEUROSCI.23-07-02634.2003","volume":"23","author":"EJ Weeber","year":"2003","unstructured":"Weeber EJ, Jiang Y-H, Elgersma Y, Varga AW, Carrasquillo Y, Brown SE, Christian JM, Mirnikjoo B, Silva A, Beaudet AL: Derangements of hippocampal calcium\/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. The Journal of neuroscience. 2003, 23 (7): 2634-2644.","journal-title":"The Journal of neuroscience"},{"issue":"4","key":"232_CR35","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/7263","volume":"2","author":"EM Quinlan","year":"1999","unstructured":"Quinlan EM, Philpot BD, Huganir RL, Bear MF: Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo. Nat Neurosci. 1999, 2 (4): 352-357. 10.1038\/7263.","journal-title":"Nat Neurosci"},{"key":"232_CR36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/1471-2377-10-91","volume":"10","author":"C Paribello","year":"2010","unstructured":"Paribello C, Tao L, Folino A, Berry-Kravis E, Tranfaglia M, Ethell IM, Ethell DW: Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 2010, 10: 91-10.1186\/1471-2377-10-91.","journal-title":"BMC Neurol"},{"issue":"12","key":"232_CR37","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S1474-4422(04)00937-8","volume":"3","author":"VW Yong","year":"2004","unstructured":"Yong VW, Wells J, Giuliani F, Casha S, Power C, Metz LM: The promise of minocycline in neurology. Lancet Neurol. 2004, 3 (12): 744-751. 10.1016\/S1474-4422(04)00937-8.","journal-title":"Lancet Neurol"},{"issue":"2","key":"232_CR38","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/bph.12139","volume":"169","author":"N Garrido-Mesa","year":"2013","unstructured":"Garrido-Mesa N, Zarzuelo A, Galvez J: Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013, 169 (2): 337-352. 10.1111\/bph.12139.","journal-title":"Br J Pharmacol"},{"issue":"163","key":"232_CR39","doi-asserted-by":"publisher","first-page":"163ra157","DOI":"10.1126\/scitranslmed.3004655","volume":"4","author":"K Egawa","year":"2012","unstructured":"Egawa K, Kitagawa K, Inoue K, Takayama M, Takayama C, Saitoh S, Kishino T, Kitagawa M, Fukuda A: Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. Sci Transl Med. 2012, 4 (163): 163ra157-163ra157. 10.1126\/scitranslmed.3004655.","journal-title":"Sci Transl Med"},{"issue":"4","key":"232_CR40","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1365-2133.1996.tb06972.x","volume":"134","author":"V Goulden","year":"1996","unstructured":"Goulden V, Glass D, Cunliffe WJ: Safety of long-term high-dose minocycline in the treatment of acne. Br J Dermatol. 1996, 134 (4): 693-695. 10.1111\/j.1365-2133.1996.tb06972.x.","journal-title":"Br J Dermatol"},{"issue":"4","key":"232_CR41","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1128\/AAC.11.4.712","volume":"11","author":"WL Fanning","year":"1977","unstructured":"Fanning WL, Gump DW, Sofferman RA: Side effects of minocycline: a double-blind study. Antimicrob Agents Chemother. 1977, 11 (4): 712-717. 10.1128\/AAC.11.4.712.","journal-title":"Antimicrob Agents Chemother"},{"key":"232_CR42","doi-asserted-by":"crossref","unstructured":"Cohen J: Statistical Power Analysis for the Behavioral Sciences. \u115f: Routledge; 2013.","DOI":"10.4324\/9780203771587"},{"key":"232_CR43","volume-title":"Essentials of Bayley Scales of Infant Development II Assessment","author":"MM Black","year":"2000","unstructured":"Black MM, Matula K: Essentials of Bayley Scales of Infant Development II Assessment. 2000, John Wiley & Sons, Inc, New York"},{"key":"232_CR44","unstructured":"NINDS Common Data Elements. National Institutes of Health 2014, \u115f:\u115f [http:\/\/www.commondataelements.ninds.nih.gov\/epilepsy.aspx#tab=Data_Standards]. Web.,"},{"issue":"2","key":"232_CR45","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/ajmg.a.30065","volume":"128","author":"SU Peters","year":"2004","unstructured":"Peters SU, Goddard\u2010Finegold J, Beaudet AL, Madduri N, Turcich M, Bacino CA: Cognitive and adaptive behavior profiles of children with Angelman syndrome. Am J Med Genet A. 2004, 128 (2): 110-113. 10.1002\/ajmg.a.30065.","journal-title":"Am J Med Genet A"},{"issue":"3","key":"232_CR46","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1023\/A:1022824225502","volume":"10","author":"M DeWitt","year":"1998","unstructured":"DeWitt M, Schreck K, Mulick J: Use of bayley scales in individuals with profound mental retardation: comparison of the first and second editions. J Dev Phys Disabil. 1998, 10 (3): 307-313. 10.1023\/A:1022824225502.","journal-title":"J Dev Phys Disabil"},{"issue":"8","key":"232_CR47","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1002\/ajmg.a.33509","volume":"152","author":"SU Peters","year":"2010","unstructured":"Peters SU, Bird LM, Kimonis V, Glaze DG, Shinawi LM, Bichell TJ, Barbieri\u2010Welge R, Nespeca M, Anselm I, Waisbren S: Double\u2212blind therapeutic trial in Angelman syndrome using betaine and folic acid. Am J Med Genet A. 2010, 152 (8): 1994-2001. 10.1002\/ajmg.a.33509.","journal-title":"Am J Med Genet A"},{"key":"232_CR48","unstructured":"Loring DW, Bowden SC: The STROBE statement and neuropsychology: lighting the way toward evidence-based practice. Clin Neuropsychol 2013, \u115f:1\u201319. ahead-of-print.,"},{"key":"232_CR49","unstructured":"Pearson Education: Using the Bayley Scales of Infant and Toddler Development, 3rd Edition, to Assess Individuals with Severe Delays, 2008. [http:\/\/images.pearsonassessments.com\/images\/tmrs\/tmrs_rg\/TechReport1.pdf?WT.mc_id=TMRS_Bayley_III_Technical_Report_1]. Web."},{"issue":"6","key":"232_CR50","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/j.1528-1167.2011.03018.x","volume":"52","author":"DW Loring","year":"2011","unstructured":"Loring DW, Lowenstein DH, Barbaro NM, Fureman BE, Odenkirchen J, Jacobs MP, Austin JK, Dlugos DJ, French JA, Gaillard WD: Common data elements in epilepsy research: development and implementation of the NINDS epilepsy CDE project. Epilepsia. 2011, 52 (6): 1186-1191. 10.1111\/j.1528-1167.2011.03018.x.","journal-title":"Epilepsia"},{"issue":"9","key":"232_CR51","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/j.1528-1167.2012.03537.x","volume":"53","author":"RL Thibert","year":"2012","unstructured":"Thibert RL, Pfeifer HH, Larson AM, Raby AR, Reynolds AA, Morgan AK, Thiele EA: Low glycemic index treatment for seizures in Angelman syndrome. Epilepsia. 2012, 53 (9): 1498-1502. 10.1111\/j.1528-1167.2012.03537.x.","journal-title":"Epilepsia"},{"issue":"12","key":"232_CR52","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.1002\/ajmg.a.34297","volume":"155A","author":"LM Bird","year":"2011","unstructured":"Bird LM, Tan WH, Bacino CA, Peters SU, Skinner SA, Anselm I, Barbieri-Welge R, Bauer-Carlin A, Gentile JK, Glaze DG, Horowitz LT, Mohan KN, Nespeca MP, Sahoo T, Sarco D, Waisbren SE, Beaudet AL: A therapeutic trial of pro-methylation dietary supplements in Angelman syndrome. Am J Med Genet A. 2011, 155A (12): 2956-2963. 10.1002\/ajmg.a.34297.","journal-title":"Am J Med Genet A"},{"issue":"7","key":"232_CR53","first-page":"28","volume":"4","author":"J Busner","year":"2007","unstructured":"Busner J, Targum SD: The clinical global impressions scale: applying a research tool in clinical practice. Psychiatry. 2007, 4 (7): 28-37.","journal-title":"Psychiatry"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12883-014-0232-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-014-0232-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-014-0232-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-014-0232-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T06:59:13Z","timestamp":1630565953000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-014-0232-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["232"],"URL":"https:\/\/doi.org\/10.1186\/s12883-014-0232-x","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"6 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"232"}}