{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:43:06Z","timestamp":1792186986852,"version":"4.4.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12883-015-0500-4","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T22:28:55Z","timestamp":1449095335000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Correlation of Tc-99\u00a0m ethyl cysteinate dimer single-photon emission computed tomography and clinical presentations in patients with low cobalamin status"],"prefix":"10.1186","volume":"15","author":[{"given":"Min-Chien","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ping","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,3]]},"reference":[{"key":"500_CR1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1176\/appi.neuropsych.11020052","volume":"24","author":"C Lachner","year":"2012","unstructured":"Lachner C, Steinle NI, Regenold WT. The neuropsychiatry of vitamin B12 deficiency in elderly patients. J Neuropsychiatr Clin Neurosci. 2012;24:5\u201315.","journal-title":"J Neuropsychiatr Clin Neurosci"},{"key":"500_CR2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1212\/WNL.56.9.1143","volume":"56","author":"DS Knopman","year":"2001","unstructured":"Knopman DS, DeKosky ST, Cummings JL, Chui H, Corey-Bloom J, Relkin N, et al. Practice parameter: diagnosis of dementia (an evidence-based review): report of the quality standards subcommittee of the american academy of neurology. Neurology. 2001;56:1143\u201353.","journal-title":"Neurology"},{"key":"500_CR3","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","volume":"58","author":"RC Petersen","year":"2001","unstructured":"Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001;58:1985\u201392.","journal-title":"Arch Neurol"},{"key":"500_CR4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0010-440X(97)90925-1","volume":"38","author":"BR Hutto","year":"1997","unstructured":"Hutto BR. Folate and cobalamin in psychiatric illness. Compr Psychiatry. 1997;38:305\u201314.","journal-title":"Compr Psychiatry"},{"key":"500_CR5","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/01.wnl.0000325581.26991.f2","volume":"71","author":"A Vogiatzoglou","year":"2008","unstructured":"Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, et al. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008;71:826\u201332.","journal-title":"Neurology"},{"key":"500_CR6","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1212\/WNL.0b013e3182315a33","volume":"77","author":"CC Tangney","year":"2011","unstructured":"Tangney CC, Aggarwal NT, Li H, Wilson RS, Decarli C, Evans DA, et al. Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination. Neurology. 2011;77:1276\u201382.","journal-title":"Neurology"},{"key":"500_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10072-010-0419-x","volume":"32","author":"C Blundo","year":"2011","unstructured":"Blundo C, Marin D, Ricci M. Vitamin B12 deficiency associated with symptoms of frontotemporal dementia. Neurol Sci. 2011;32:101\u20135.","journal-title":"Neurol Sci"},{"key":"500_CR8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/13554790802032242","volume":"14","author":"G Akdal","year":"2008","unstructured":"Akdal G, Yener GG, Kurt P. Treatment responsive executive and behavioral dysfunction associated with Vitamin B12 deficiency. Neurocase. 2008;14:147\u201350.","journal-title":"Neurocase"},{"key":"500_CR9","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/ajcn\/82.6.1320","volume":"82","author":"DJ Stott","year":"2005","unstructured":"Stott DJ, MacIntosh G, Lowe GD, Rumley A, McMahon AD, Langhorne P, et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr. 2005;82:1320\u20136.","journal-title":"Am J Clin Nutr"},{"key":"500_CR10","first-page":"1456","volume":"41","author":"F Tanaka","year":"2000","unstructured":"Tanaka F, Vines D, Tsuchida T, Freedman M, Ichise M. Normal patterns on 99mTc-ECD brain SPECT scans in adults. J Nucl Med. 2000;41:1456\u201361.","journal-title":"J Nucl Med"},{"key":"500_CR11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR. \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189\u201398.","journal-title":"J Psychiatr Res"},{"key":"500_CR12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S1041610294001602","volume":"6","author":"EL Teng","year":"1994","unstructured":"Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, et al. The Cognitive Abilities Screening Instrument (CASI): A practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr. 1994;6:45\u201356.","journal-title":"Int Psychogeriatr"},{"key":"500_CR13","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","volume":"43","author":"JC Morris","year":"1993","unstructured":"Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412\u20134.","journal-title":"Neurology"},{"key":"500_CR14","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1212\/WNL.44.12.2308","volume":"44","author":"JL Cummings","year":"1994","unstructured":"Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308\u201314.","journal-title":"Neurology"},{"key":"500_CR15","first-page":"180","volume":"21","author":"KN Lin","year":"2012","unstructured":"Lin KN, Wang PN, Liu HC, Teng EL. Cognitive Abilities Screening Instrument, Chinese version 2.0 (CASI C-2.0): Administration and clinical application. Acta Neurol Taiwanica. 2012;21:180\u20139.","journal-title":"Acta Neurol Taiwanica"},{"key":"500_CR16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1037\/a0014723","volume":"123","author":"TL Moore","year":"2009","unstructured":"Moore TL, Schettler SP, Killiany RJ, Rosene DL, Moss MB. Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta). Behav Neurosci. 2009;123:231\u201341.","journal-title":"Behav Neurosci"},{"key":"500_CR17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0166-2236(00)01633-7","volume":"23","author":"J Duncan","year":"2000","unstructured":"Duncan J, Owen AM. Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci. 2000;23:475\u201383.","journal-title":"Trends Neurosci"},{"key":"500_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/1874440001105010040","volume":"5","author":"DG Amen","year":"2011","unstructured":"Amen DG, Trujillo M, Newberg A, Willeumier K, Tarzwell R, Wu JC, et al. Brain SPECT imaging in complex psychiatric cases: an evidence-based, underutilized tool. Open Neuroimag J. 2011;5:40\u20138.","journal-title":"Open Neuroimag J"},{"key":"500_CR19","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1098\/rstb.1996.0124","volume":"351","author":"T Shallice","year":"1996","unstructured":"Shallice T, Burgess P. The domain of supervisory processes and temporal organization of behaviour. Philos Trans R Soc Lond B Biol Sci. 1996;351:1405\u201311.","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"500_CR20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.neuro.24.1.167","volume":"24","author":"EK Miller","year":"2001","unstructured":"Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24:167\u2013202.","journal-title":"Annu Rev Neurosci"},{"key":"500_CR21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1467-8721.2009.01615.x","volume":"18","author":"MT Banich","year":"2009","unstructured":"Banich MT. Executive function: The search for an integrated account. Curr Dir Psychol Sci. 2009;18:89\u201394.","journal-title":"Curr Dir Psychol Sci"},{"key":"500_CR22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/jnnp.72.1.12","volume":"72","author":"HA Ring","year":"2002","unstructured":"Ring HA, Serra-Mestres J. Advance in neuropsychiatry Neuropsychiatry of the basal ganglia. J Neurol Neurosurg Psychiatry. 2002;72:12\u201321.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"500_CR23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0959-4388(95)80023-9","volume":"5","author":"LR Squire","year":"1995","unstructured":"Squire LR, Alvarez P. Retrograde amnesia and memory consolidation: a neurobiological perspective. Curr Opin Neurobiol. 1995;5:169\u201377.","journal-title":"Curr Opin Neurobiol"},{"key":"500_CR24","first-page":"1","volume":"3","author":"MJ Farah","year":"2012","unstructured":"Farah MJ, Gillihan SJ. The puzzle of neuroimaging and psychiatric diagnosis: technology and nosology in an evolving discipline. AJOB Neurosci. 2012;3:1\u201311.","journal-title":"AJOB Neurosci"},{"key":"500_CR25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2004.12.010","volume":"27","author":"B Borroni","year":"2006","unstructured":"Borroni B, Anchisi D, Paghera B, Vicini B, Kerrouche N, Garibotto V, et al. Combined 99mTc-ECD SPECT and neuropsychological studies in MCI for the assessment of conversion to AD. Neurobiol Aging. 2006;27:24\u201331.","journal-title":"Neurobiol Aging"},{"key":"500_CR26","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1212\/WNL.59.2.198","volume":"59","author":"DA Bennett","year":"2002","unstructured":"Bennett DA, Wilson RS, Schneider JA, Evans DA, Beckett LA, Aggarwal NT, et al. Natural history of mild cognitive impairment in older persons. Neurology. 2002;59:198\u2013205.","journal-title":"Neurology"},{"key":"500_CR27","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s00415-008-0897-4","volume":"255","author":"F Nobili","year":"2008","unstructured":"Nobili F, Frisoni GB, Portet F, Verhey F, Rodriguez G, Caroli A, et al. Brain SPECT in subtypes of mild cognitive impairment. Findings from the DESCRIPA multicenter study. J Neurol. 2008;255:1344\u201353.","journal-title":"J Neurol"},{"key":"500_CR28","first-page":"199","volume":"12","author":"K Nilsson","year":"2000","unstructured":"Nilsson K, Warkentin S, Hultberg B, F\u00e4ldt R, Gustafson L. Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements. Aging (Milano). 2000;12:199\u2013207.","journal-title":"Aging (Milano)"},{"key":"500_CR29","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fasebj.4.5.2407589","volume":"4","author":"RV Banerjee","year":"1990","unstructured":"Banerjee RV, Matthews RG. Cobalamin-dependent methionine synthase. FASEB J. 1990;4:1450\u20139.","journal-title":"FASEB J"},{"key":"500_CR30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pneurobio.2009.04.004","volume":"88","author":"G Scalabrino","year":"2009","unstructured":"Scalabrino G. The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency. Prog Neurobiol. 2009;88:203\u201320.","journal-title":"Prog Neurobiol"},{"key":"500_CR31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/nimg.1995.1017","volume":"2","author":"M Jueptner","year":"1995","unstructured":"Jueptner M, Weiller C. Review: does measurement of regional cerebral blood flow reflect synaptic activity? Implications for PET and fMRI. Neuroimage. 1995;2:148\u201356.","journal-title":"Neuroimage"},{"key":"500_CR32","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1471-4159.1983.tb08107.x","volume":"40","author":"AM Hakim","year":"1983","unstructured":"Hakim AM, Cooper BA, Rosenblatt DS, Pappius HM. Local cerebral glucose utilization in two models of B12 deficiency. J Neurochem. 1983;40:1155\u201360.","journal-title":"J Neurochem"},{"key":"500_CR33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/ajh.2830340205","volume":"34","author":"J Lindenbaum","year":"1990","unstructured":"Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol. 1990;34:99\u2013107.","journal-title":"Am J Hematol"},{"key":"500_CR34","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2796.2004.01437.x","volume":"257","author":"AM Hvas","year":"2005","unstructured":"Hvas AM, Nexo E. Holotranscobalamin--a first choice assay for diagnosing early vitamin B deficiency? J Intern Med. 2005;257:289\u201398.","journal-title":"J Intern Med"},{"key":"500_CR35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2796.2011.02484.x","volume":"271","author":"B Hooshmand","year":"2012","unstructured":"Hooshmand B, Solomon A, Kareholt I, Rusanen M, Hanninen T, Leiviska J, et al. Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study. J Intern Med. 2012;271:204\u201312.","journal-title":"J Intern Med"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-015-0500-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:49:51Z","timestamp":1567385391000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2377\/15\/251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["500"],"URL":"https:\/\/doi.org\/10.1186\/s12883-015-0500-4","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"251"}}