{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:41:34Z","timestamp":1789591294681,"version":"build-2803163510"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft (DE)","doi-asserted-by":"publisher","award":["DFG Exc 257"],"award-info":[{"award-number":["DFG Exc 257"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12883-015-0517-8","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T08:46:14Z","timestamp":1450860374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Quantitative motor assessment of muscular weakness in myasthenia gravis: a pilot study"],"prefix":"10.1186","volume":"15","author":[{"given":"Sarah","family":"Hoffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Siedler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander U.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie K.","family":"Piper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Reilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Meisel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"issue":"2","key":"517_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/mus.20950","volume":"37","author":"D Grob","year":"2008","unstructured":"Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. Muscle Nerve. 2008;37(2):141\u20139.","journal-title":"Muscle Nerve"},{"key":"517_CR2","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2377-10-46","volume":"10","author":"AS Carr","year":"2010","unstructured":"Carr AS, Cardwell CR, McCarron PO, McConville J. A systematic review of population based epidemiological studies in Myasthenia Gravis. BMC Neurol. 2010;10:46.","journal-title":"BMC Neurol"},{"issue":"1","key":"517_CR3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1212\/WNL.55.1.16","volume":"55","author":"A Jaretzki 3rd","year":"2000","unstructured":"Jaretzki 3rd A, Barohn RJ, Ernstoff RM, Kaminski HJ, Keesey JC, Penn AS, et al. Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America. Neurology. 2000;55(1):16\u201323.","journal-title":"Neurology"},{"issue":"4","key":"517_CR4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s004150050585","volume":"247","author":"T Sharshar","year":"2000","unstructured":"Sharshar T, Chevret S, Mazighi M, Chillet P, Huberfeld G, Berreotta C, et al. Validity and reliability of two muscle strength scores commonly used as endpoints in assessing treatment of myasthenia gravis. J Neurol. 2000;247(4):286\u201390.","journal-title":"J Neurol"},{"issue":"7","key":"517_CR5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.nmd.2006.05.006","volume":"16","author":"M Benatar","year":"2006","unstructured":"Benatar M. A systematic review of diagnostic studies in myasthenia gravis. Neuromuscul Disord. 2006;16(7):459\u201367.","journal-title":"Neuromuscul Disord"},{"issue":"7","key":"517_CR6","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/jnnp.43.7.622","volume":"43","author":"E Stalberg","year":"1980","unstructured":"Stalberg E. Clinical electrophysiology in myasthenia gravis. J Neurol Neurosurg Psychiatry. 1980;43(7):622\u201333.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"517_CR7","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1212\/01.WNL.0000163988.28892.79","volume":"64","author":"RS Bedlack","year":"2005","unstructured":"Bedlack RS, Simel DL, Bosworth H, Samsa G, Tucker-Lipscomb B, Sanders DB. Quantitative myasthenia gravis score: assessment of responsiveness and longitudinal validity. Neurology. 2005;64(11):1968\u201370.","journal-title":"Neurology"},{"issue":"1","key":"517_CR8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1006\/exnr.2000.7348","volume":"163","author":"AM Gordon","year":"2000","unstructured":"Gordon AM, Quinn L, Reilmann R, Marder K. Coordination of prehensile forces during precision grip in Huntington\u2019s disease. Exp Neurol. 2000;163(1):136\u201348.","journal-title":"Exp Neurol"},{"issue":"12","key":"517_CR9","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1002\/mds.23816","volume":"26","author":"R Reilmann","year":"2011","unstructured":"Reilmann R, Bohlen S, Kirsten F, Ringelstein EB, Lange HW. Assessment of involuntary choreatic movements in Huntington\u2019s disease--toward objective and quantitative measures. Mov Disord. 2011;26(12):2267\u201373.","journal-title":"Mov Disord"},{"key":"517_CR10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1749-6632.1998.tb11015.x","volume":"841","author":"RJ Barohn","year":"1998","unstructured":"Barohn RJ, McIntire D, Herbelin L, Wolfe GI, Nations S, Bryan WW. Reliability testing of the quantitative myasthenia gravis score. Ann N Y Acad Sci. 1998;841:769\u201372.","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"517_CR11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.57.5.920","volume":"57","author":"R Reilmann","year":"2001","unstructured":"Reilmann R, Kirsten F, Quinn L, Henningsen H, Marder K, Gordon AM. Objective assessment of progression in Huntington\u2019s disease: a 3-year follow-up study. Neurology. 2001;57(5):920\u20134.","journal-title":"Neurology"},{"issue":"1","key":"517_CR12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","volume":"11","author":"SJ Tabrizi","year":"2012","unstructured":"Tabrizi SJ, Reilmann R, Roos RA, Durr A, Leavitt B, Owen G, et al. Potential endpoints for clinical trials in premanifest and early Huntington\u2019s disease in the TRACK-HD study: analysis of 24\u00a0month observational data. Lancet Neurol. 2012;11(1):42\u201353.","journal-title":"Lancet Neurol."},{"issue":"7","key":"517_CR13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","volume":"12","author":"SJ Tabrizi","year":"2013","unstructured":"Tabrizi SJ, Scahill RI, Owen G, Durr A, Leavitt BR, Roos RA, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol. 2013;12(7):637\u201349.","journal-title":"Lancet Neurol."},{"issue":"3","key":"517_CR14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/mds.26174","volume":"30","author":"R Reilmann","year":"2015","unstructured":"Reilmann R, Rouzade-Dominguez ML, Saft C, Sussmuth SD, Priller J, Rosser A, et al. A randomized, placebo-controlled trial of AFQ056 for the treatment of chorea in Huntington\u2019s disease. Mov Disord. 2015;30(3):427\u201331.","journal-title":"Mov Disord"},{"issue":"24","key":"517_CR15","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1212\/01.wnl.0000263481.14289.90","volume":"68","author":"M Benatar","year":"2007","unstructured":"Benatar M, Kaminski HJ, Quality Standards Subcommittee of the American Academy of N. Evidence report: the medical treatment of ocular myasthenia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2007;68(24):2144\u20139.","journal-title":"Neurology"},{"key":"517_CR16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2377-14-142","volume":"14","author":"S Suzuki","year":"2014","unstructured":"Suzuki S, Murai H, Imai T, Nagane Y, Masuda M, Tsuda E, et al. Quality of life in purely ocular myasthenia in Japan. BMC Neurol. 2014;14:142.","journal-title":"BMC Neurol"},{"issue":"9","key":"517_CR17","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/(SICI)1097-4598(199909)22:9<1222::AID-MUS8>3.0.CO;2-R","volume":"22","author":"DH Weinberg","year":"1999","unstructured":"Weinberg DH, Rizzo 3rd JF, Hayes MT, Kneeland MD, Kelly Jr JJ. Ocular myasthenia gravis: predictive value of single-fiber electromyography. Muscle Nerve. 1999;22(9):1222\u20137.","journal-title":"Muscle Nerve"},{"issue":"4","key":"517_CR18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/ane.12261","volume":"130","author":"S Hoffmann","year":"2014","unstructured":"Hoffmann S, Kohler S, Ziegler A, Meisel A. Glucocorticoids in myasthenia gravis - if, when, how, and how much? Acta Neurol Scand. 2014;130(4):211\u201321.","journal-title":"Acta Neurol Scand"},{"issue":"16","key":"517_CR19","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1002\/mds.23300","volume":"25","author":"R Reilmann","year":"2010","unstructured":"Reilmann R, Bohlen S, Klopstock T, Bender A, Weindl A, Saemann P, et al. Grasping premanifest Huntington\u2019s disease - shaping new endpoints for new trials. Mov Disord. 2010;25(16):2858\u201362.","journal-title":"Mov Disord"},{"issue":"5","key":"517_CR20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/ana.410140504","volume":"14","author":"CT Bever Jr","year":"1983","unstructured":"Bever Jr CT, Aquino AV, Penn AS, Lovelace RE, Rowland LP. Prognosis of ocular myasthenia. Ann Neurol. 1983;14(5):516\u20139.","journal-title":"Ann Neurol"},{"issue":"2","key":"517_CR21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0960-8966(00)00173-5","volume":"11","author":"A Evoli","year":"2001","unstructured":"Evoli A, Batocchi AP, Minisci C, Di Schino C, Tonali P. Therapeutic options in ocular myasthenia gravis. Neuromuscul Disord. 2001;11(2):208\u201316.","journal-title":"Neuromuscul Disord"},{"key":"517_CR22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2377-13-132","volume":"13","author":"A Elsais","year":"2013","unstructured":"Elsais A, Wyller VB, Loge JH, Kerty E. Fatigue in myasthenia gravis: is it more than muscular weakness? BMC Neurol. 2013;13:132.","journal-title":"BMC Neurol"},{"issue":"4","key":"517_CR23","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1212\/WNL.0b013e31827f07be","volume":"80","author":"BM Kluger","year":"2013","unstructured":"Kluger BM, Krupp LB, Enoka RM. Fatigue and fatigability in neurologic illnesses: proposal for a unified taxonomy. Neurology. 2013;80(4):409\u201316.","journal-title":"Neurology"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-015-0517-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T22:24:19Z","timestamp":1498256659000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.biomedcentral.com\/1471-2377\/15\/265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["517"],"URL":"https:\/\/doi.org\/10.1186\/s12883-015-0517-8","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"265"}}