{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T11:39:08Z","timestamp":1794051548081,"version":"4.8.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["81173663"],"award-info":[{"award-number":["81173663"]}]},{"name":"National Key Technology Program","award":["2006BA101A10"],"award-info":[{"award-number":["2006BA101A10"]}]},{"name":"National Key Technology Program","award":["2011BAI08B03"],"award-info":[{"award-number":["2011BAI08B03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12883-016-0714-0","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:08:45Z","timestamp":1475712525000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Kidney function is associated with severity of white matter hyperintensity in patients with acute ischemic stroke\/TIA"],"prefix":"10.1186","volume":"16","author":[{"given":"Lixia","family":"Zong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"714_CR1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/S1474-4422(14)70026-2","volume":"13","author":"K Toyoda","year":"2014","unstructured":"Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014;13:823\u201333.","journal-title":"Lancet Neurol"},{"key":"714_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000346944","volume":"179","author":"K Toyoda","year":"2013","unstructured":"Toyoda K. Cerebrorenal interaction and stroke. Contrib Nephrol. 2013;179:1\u20136.","journal-title":"Contrib Nephrol"},{"key":"714_CR3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/hr.2008.27","volume":"32","author":"S Ito","year":"2009","unstructured":"Ito S, Nagasawa T, Abe M, Mori T. Strain vessel hypothesis: a viewpoint for linkage of albuminuria andcerebro-cardiovascular risk. Hypertens Res. 2009;32:115\u201321.","journal-title":"Hypertens Res"},{"key":"714_CR4","doi-asserted-by":"publisher","first-page":"3121","DOI":"10.1161\/STROKEAHA.107.493593","volume":"38","author":"M Khatri","year":"2007","unstructured":"Khatri M, Wright CB, Nickolas TL, Yoshita M, Paik MC, Kranwinkel G, et al. Chronic kidney disease is associated with white matter hyperintensity volume: the Northern Manhattan study (nomas). Stroke. 2007;38:3121\u20136.","journal-title":"Stroke"},{"key":"714_CR5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1161\/STROKEAHA.107.493494","volume":"39","author":"MA Ikram","year":"2008","unstructured":"Ikram MA, Vernooij MW, Hofman A, Niessen WJ, van der Lugt A, Breteler MM. Kidney function is related to cerebral small vessel disease. Stroke. 2008;39:55\u201361.","journal-title":"Stroke"},{"key":"714_CR6","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jns.2008.04.029","volume":"272","author":"M Wada","year":"2008","unstructured":"Wada M, Nagasawa H, Iseki C, Takahashi Y, Sato H, Arawaka S, et al. Cerebral small vessel disease and chronic kidney disease (ckd): results of a cross-sectional study in community-based Japanese elderly. J Neurol Sci. 2008;272:36\u201342.","journal-title":"J Neurol Sci"},{"key":"714_CR7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.05.007","volume":"19","author":"NS Rost","year":"2010","unstructured":"Rost NS, Rahman R, Sonni S, Kanakis A, Butler C, Massasa E, et al. Determinants of white matter hyperintensity volume in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2010;19:230\u20135.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"714_CR8","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1161\/STROKEAHA.110.587352","volume":"41","author":"NK Oksala","year":"2010","unstructured":"Oksala NK, Salonen T, Strandberg T, Oksala A, Pohjasvaara T, Kaste M, et al. Cerebral small vessel disease and kidney function predict long-term survival in patients with acute stroke. Stroke. 2010;41:1914\u201320.","journal-title":"Stroke"},{"key":"714_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.5853\/jos.2015.17.2.101","volume":"17","author":"BJ Kim","year":"2015","unstructured":"Kim BJ, Lee SH. Prognostic impact of cerebral small vessel disease on stroke outcome. J Stroke. 2015;17:101\u201310.","journal-title":"J Stroke"},{"key":"714_CR10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/ijs.12264","volume":"9","author":"A Rowat","year":"2014","unstructured":"Rowat A, Graham C, Dennis M. Renal dysfunction in stroke patients: a hospital-based cohort study and systematic review. Int J Stroke. 2014;9:633\u20139.","journal-title":"Int J Stroke"},{"key":"714_CR11","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2015.01.038","volume":"239","author":"SJ Yeh","year":"2015","unstructured":"Yeh SJ, Jeng JS, Tang SC, Liu CH, Hsu SP, Chen CH, et al. Low estimated glomerular filtration rate is associated with poor outcomes in patients who suffered a large artery atherosclerosis stroke. Atherosclerosis. 2015;239:328\u201334.","journal-title":"Atherosclerosis"},{"key":"714_CR12","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","volume":"43","author":"F Fazekas","year":"1993","unstructured":"Fazekas F, Kleinert R, Offenbacher H, Schmidt R, Kleinert G, Payer F, et al. Pathologic correlates of incidental mri white matter signal hyperintensities. Neurology. 1993;43:1683\u20139.","journal-title":"Neurology"},{"key":"714_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1747-4949.2011.00648.x","volume":"6","author":"B Peng","year":"2011","unstructured":"Peng B, Zhu Y, Cui L, Ni J, Xu W, Zhou L, et al. Standard medical management in secondary prevention of ischemic stroke in china (smart). Int J Stroke. 2011;6:461\u20135.","journal-title":"Int J Stroke"},{"key":"714_CR14","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1681\/ASN.2006040368","volume":"17","author":"YC Ma","year":"2006","unstructured":"Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, Li Y, et al. Modified glomerular filtration rate estimating equation for chinese patients with chronic kidney disease. J Am Soc Nephrol. 2006;17:2937\u201344.","journal-title":"J Am Soc Nephrol"},{"key":"714_CR15","first-page":"S1","volume":"39","author":"National Kidney F","year":"2002","unstructured":"National Kidney F. K\/doqi clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39:S1\u2013266.","journal-title":"Am J Kidney Dis"},{"key":"714_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. Mr signal abnormalities at 1.5\u00a0t in alzheimer\u2019s dementia and normal aging. AJR. Am J Roentgenol. 1987;149:351\u20136.","journal-title":"Am J Roentgenol"},{"key":"714_CR17","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1161\/01.STR.0000135226.53499.85","volume":"35","author":"T Jeerakathil","year":"2004","unstructured":"Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D\u2019Agostino RB, et al. Stroke risk profile predicts white matter hyperintensity volume: the Framingham study. Stroke. 2004;35:1857\u201361.","journal-title":"Stroke"},{"key":"714_CR18","first-page":"38","volume":"30","author":"U Ghaffar","year":"2016","unstructured":"Ghaffar U, Maharjan N, Moore PC. Predictors of ckd and rate of decline in egfr in the elderly: a case-cohort study. Nephrol News Issues. 2016;30:38\u201345.","journal-title":"Nephrol News Issues"},{"key":"714_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-011-0851-x","volume":"122","author":"R Schmidt","year":"2011","unstructured":"Schmidt R, Schmidt H, Haybaeck J, Loitfelder M, Weis S, Cavalieri M, et al. Heterogeneity in age-related white matter changes. Acta Neuropathol. 2011;122:171\u201385.","journal-title":"Acta Neuropathol"},{"key":"714_CR20","doi-asserted-by":"publisher","first-page":"e005598","DOI":"10.1136\/bmjopen-2014-005598","volume":"4","author":"A Abe","year":"2014","unstructured":"Abe A, Nishiyama Y, Harada-Abe M, Okubo S, Ueda M, Mishina M, et al. Relative risk values of age, acrolein, il-6 and crp as markers of periventricular hyperintensities: a cross-sectional study. BMJ Open. 2014;4:e005598.","journal-title":"BMJ Open"},{"key":"714_CR21","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.03.015","volume":"21","author":"W Takahashi","year":"2012","unstructured":"Takahashi W, Tsukamoto Y, Takizawa S, Kawada S, Takagi S. Relationship between chronic kidney disease and white matter hyperintensities on magnetic resonance imaging. J Stroke Cerebrovasc Dis. 2012;21:18\u201323.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"714_CR22","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1161\/STROKEAHA.108.520882","volume":"40","author":"G Yahalom","year":"2009","unstructured":"Yahalom G, Schwartz R, Schwammenthal Y, Merzeliak O, Toashi M, Orion D, et al. Chronic kidney disease and clinical outcome in patients with acute stroke. Stroke. 2009;40:1296\u2013303.","journal-title":"Stroke"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-016-0714-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12883-016-0714-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-016-0714-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T20:44:48Z","timestamp":1487709888000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-016-0714-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1186\/s12883-016-0714-0","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]},"article-number":"193"}}