{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:13:29Z","timestamp":1777392809494,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12883-017-0863-9","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T12:49:17Z","timestamp":1494506957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls"],"prefix":"10.1186","volume":"17","author":[{"given":"Bontle G.","family":"Malatji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helgard","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayne","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo F.H.","family":"Engelke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron A.","family":"Wevers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"van Reenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolus J.","family":"Reinecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,11]]},"reference":[{"issue":"2","key":"863_CR1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","author":"F Wolfe","year":"1990","unstructured":"Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum. 1990;33(2):160\u201372.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"863_CR2","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","volume":"62","author":"F Wolfe","year":"2010","unstructured":"Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600\u201310.","journal-title":"Arthritis Care Res"},{"key":"863_CR3","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.semarthrit.2008.12.003","volume":"39","author":"JC Branco","year":"2010","unstructured":"Branco JC, Bannwarth B, Failde I, Carbonell JA, Blotman F, Spaeth M, Saraiva F, et al. Prevalence of fibromyalgia: a survey in five European countries. Semin Arthritis Rheum. 2010;39:448\u201353.","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"863_CR4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"RC Lawrence","year":"2008","unstructured":"Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: part II. Arthritis Rheum. 2008;58(1):26\u201335.","journal-title":"Arthritis Rheum"},{"key":"863_CR5","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/art.1780371106","volume":"37","author":"IJ Russell","year":"1994","unstructured":"Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum. 1994;37:1593\u2013601.","journal-title":"Arthritis Rheum"},{"key":"863_CR6","first-page":"95","volume":"19","author":"MB Yunus","year":"1992","unstructured":"Yunus MB, Dailey JW, Aldag JC, Masi AT, Jobe PC. Plasma and urinary catecholamines in primary fibromyalgia: a controlled study. J Rheumatol. 1992;19:95\u20137.","journal-title":"J Rheumatol"},{"key":"863_CR7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/rheumatology\/40.3.290","volume":"40","author":"E Legangneux","year":"2001","unstructured":"Legangneux E, Mora JJ, Spreux-Varoquaux O, Thorin I, Herrou M, Alvado G, et al. Cerebrospinal fluid biogenic amine metabolites, plasma-rich platelet serotonin and [3H]imipramine reuptake in the primary fibromyalgia syndrome. Rheumatol. 2001;40:290\u20136.","journal-title":"Rheumatol"},{"issue":"4","key":"863_CR8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s11916-002-0048-z","volume":"6","author":"HP Meyer","year":"2002","unstructured":"Meyer HP. Myofascial pain syndrome and its suggested role in the pathogenesis and treatment of fibromyalgia syndrome. Curr Pain Headache Rep. 2002;6(4):274\u201383.","journal-title":"Curr Pain Headache Rep"},{"issue":"4","key":"863_CR9","first-page":"235","volume":"7","author":"JS Levine","year":"2011","unstructured":"Levine JS, Burakoff R. Extraintestinal manifestations of inflammatory bowel disease. Gastroenterol Hepatol (NY). 2011;7(4):235\u201341.","journal-title":"Gastroenterol Hepatol (NY)"},{"issue":"5","key":"863_CR10","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.mayocp.2015.03.014","volume":"90","author":"DJ Clauw","year":"2015","unstructured":"Clauw DJ. Fibromyalgia and related conditions. Mayo Clin Proc Elsevier. 2015;90(5):680\u201392.","journal-title":"Mayo Clin Proc Elsevier"},{"key":"863_CR11","first-page":"18","volume":"5","author":"M-E Dumas","year":"2013","unstructured":"Dumas M-E, Davidovic L. Metabolic phenotyping and systems biology approaches to understanding neurological disorders. F1000Prime Rep. 2013;5:18.","journal-title":"F1000Prime Rep"},{"key":"863_CR12","volume-title":"Abstract 382: muscle metabolites detected in urine in fibromyalgia and chronic fatigue syndrome may suggest ongoing muscle damage","author":"SCM Richards","year":"2001","unstructured":"Richards SCM, Bell J, Cheung Y-L, Cleare A, Scott DL. Abstract 382: muscle metabolites detected in urine in fibromyalgia and chronic fatigue syndrome may suggest ongoing muscle damage. 2001."},{"key":"863_CR13","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1039\/c3an36615d","volume":"138","author":"KV Hackshaw","year":"2013","unstructured":"Hackshaw KV, Rodriguez-Saona L, Plans M, Bell LN, Buffington CAT. A bloodspot-based diagnostic test for fibromyalgia syndrome and related disorders. Analyst. 2013;138:4453\u201362.","journal-title":"Analyst"},{"issue":"9","key":"863_CR14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107626","volume":"9","author":"P Caboni","year":"2014","unstructured":"Caboni P, Liori B, Kumar A, Santoru ML, Asthana S, Pieroni E, et al. Metabolomics analysis and modeling suggest a Lysophosphocholines-PAF receptor interaction in fibromyalgia. PLoS One. 2014;9(9):e107626.","journal-title":"PLoS One"},{"key":"863_CR15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/CBF.S38161","volume":"4","author":"C Giacomelli","year":"2014","unstructured":"Giacomelli C, Sernissi F, Rossi A, Bombardieri S, Bazzichi L. Biomarkers in fibromyalgia: a review. Curr Biomark Find. 2014;4:35\u201341.","journal-title":"Curr Biomark Find"},{"key":"863_CR16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00296-011-1990-z","volume":"32","author":"Y Xiao","year":"2012","unstructured":"Xiao Y, Russell IJ, Liu YG. A brain-derived neurotrophic factor polymorphism Val66Met identifies fibromyalgia syndrome subgroup with higher body mass index and C-reactive protein. Rheumatol Int. 2012;32:2479\u201385.","journal-title":"Rheumatol Int"},{"issue":"5","key":"863_CR17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/ar2830","volume":"11","author":"RM Bennett","year":"2009","unstructured":"Bennett RM, Friend R, Jones KD, Ward R, Han BK, Ross RL. The revised fibromyalgia impact questionnaire (FIQR): validation and psychometric properties. Arthritis Res Ther. 2009;11(5):415.","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"863_CR18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1373\/clinchem.2003.020214","volume":"50","author":"UF Engelke","year":"2004","unstructured":"Engelke UF, Liebrand-van Sambeek ML, De Jong JG, Leroy JG, Morava \u00c9, Smeitink JA, et al. N-acetylated metabolites in urine: proton nuclear magnetic resonance spectroscopic study on patients with inborn errors of metabolism. Clin Chem. 2004;50(1):58\u201366.","journal-title":"Clin Chem"},{"issue":"3","key":"863_CR19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1023\/A:1005313524869","volume":"20","author":"RA Wevers","year":"1997","unstructured":"Wevers RA, Engelke U, Rotteveel JJ, Heerschap A, De Jong JG, Abeling NG, et al. 1H NMR spectroscopy of body fluids in patients with inborn errors of purine and pyrimidine metabolism. J Inherit Metab Dis. 1997;20(3):345\u201350.","journal-title":"J Inherit Metab Dis"},{"key":"863_CR20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/nbm.980","volume":"18","author":"MR Viant","year":"2005","unstructured":"Viant MR, Lyeth BG, Miller MG, Berman RF. An NMR metabolomic investigation of early metabolic disturbances following traumatic brain injury in a mammalian model. NMR Biomed. 2005;18:507\u201316.","journal-title":"NMR Biomed"},{"key":"863_CR21","first-page":"92","volume":"1","author":"B Worley","year":"2013","unstructured":"Worley B, Powers R. Multivariate analysis in metabolomics. Curr Metabolomics. 2013;1:92\u2013107.","journal-title":"Curr Metabolomics"},{"key":"863_CR22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0190-9622(96)80110-1","volume":"34","author":"CM Ditre","year":"1996","unstructured":"Ditre CM, Griffin TD, Murphy GF, Sueki H, Telegan B, Johnson WC, et al. Effects of 2-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. J Am Acad Dermatol. 1996;34:187\u201395.","journal-title":"J Am Acad Dermatol"},{"key":"863_CR23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000017324","volume":"20","author":"L Pellerin","year":"1998","unstructured":"Pellerin L, Pellegri G, Bittar PG, Charnay Y, Bouras C, Martin JL, et al. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev Neurosci. 1998;20:291\u20139.","journal-title":"Dev Neurosci"},{"key":"863_CR24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","volume":"72","author":"RJ Huxtable","year":"1992","unstructured":"Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72:101\u201363.","journal-title":"Physiol Rev"},{"issue":"5","key":"863_CR25","doi-asserted-by":"crossref","first-page":"C1934","DOI":"10.1152\/ajpcell.00593.2006","volume":"292","author":"I Morales","year":"2007","unstructured":"Morales I, Dopico JG, Sabate M, Gonzalez-Hernandez T, Rodriguez M. Substantia nigra osmoregulation: taurine and ATP involvement. Am J Physiol Cell Physiol. 2007;292(5):C1934\u201341.","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"863_CR26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jnutbio.2004.12.005","volume":"16","author":"KS Solanky","year":"2005","unstructured":"Solanky KS, Bailey NJ, Beckwith-Hall BM, Bingham S, Davis A, et al. Biofluid 1H NMR-based metabonomic techniques in nutrition research - metabolic effects of dietary isoflavones in humans. J Nutr Biochem. 2005;16(4):236\u201344.","journal-title":"J Nutr Biochem"},{"issue":"1","key":"863_CR27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/pr800548z","volume":"8","author":"I Bertini","year":"2008","unstructured":"Bertini I, Calabro A, De Carli V, Luchinat C, Nepi S, Porfirio B, Tenori L. The metabonomic signature of celiac disease. J Proteome Res. 2008;8(1):170\u20137.","journal-title":"J Proteome Res"},{"key":"863_CR28","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1073\/pnas.0712038105","volume":"105","author":"M Li","year":"2008","unstructured":"Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, et al. Symbiotc gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A. 2008;105:2117\u201322.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"863_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-1597-9","volume":"16","author":"S Mason","year":"2016","unstructured":"Mason S, Reinecke CJ, Kulik W, van Cruchten A, Solomons R, van Furth MT. Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid. BMC Infect Dis. 2016;16(1):1.","journal-title":"BMC Infect Dis"},{"key":"863_CR30","volume-title":"Discovering statistics using IBM SPSS statistics: and sex and drugs and rock 'n' roll","author":"AP Field","year":"2009","unstructured":"Field AP. Discovering statistics using IBM SPSS statistics: and sex and drugs and rock 'n' roll. 3rd ed. London: Sage Publications; 2009.","edition":"3"},{"key":"863_CR31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/00220970109599499","volume":"70","author":"B Thompson","year":"2001","unstructured":"Thompson B. Significance, effect sizes, stepwise methods, and other issues: strong arguments move the field. J Exp Educ. 2001;70:80\u201393.","journal-title":"J Exp Educ"},{"key":"863_CR32","first-page":"79","volume-title":"Statistical power analysis of the behavioural sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J. Statistical power analysis of the behavioural sciences. Revised ed. New York: Academic Press, Inc.; 1988. p. 79\u201381.","edition":"Revised"},{"issue":"2","key":"863_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.nbd.2009.02.019","volume":"35","author":"MP Quinones","year":"2009","unstructured":"Quinones MP, Kaddurah-Daouk R. Metabolomics tools for identifying biomarkers for neuropsychiatric diseases. Neurobiol Dis. 2009;35(2):165\u201376.","journal-title":"Neurobiol Dis"},{"issue":"2","key":"863_CR34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/nbm.1428","volume":"23","author":"AJ Sinclair","year":"2010","unstructured":"Sinclair AJ, Viant MR, Ball AK, Burdon MA, Walker EA, Stewart PM, et al. NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases- a diagnostic tool? NMR Biomed. 2010;23(2):123\u201332.","journal-title":"NMR Biomed"},{"issue":"8","key":"863_CR35","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/rheumatology\/ken220","volume":"47","author":"P M\u00e4ntyselk\u00e4","year":"2008","unstructured":"M\u00e4ntyselk\u00e4 P, Miettola J, Niskanen L, Kumpusalo E. Glucose regulation and chronic pain at multiple sites. Rheumatology. 2008;47(8):1235\u20138.","journal-title":"Rheumatology"},{"issue":"1","key":"863_CR36","doi-asserted-by":"crossref","first-page":"a000588","DOI":"10.1101\/mcs.a000588","volume":"1","author":"CB Clish","year":"2015","unstructured":"Clish CB. Metabolomics: an emerging but powerful tool for precision medicine. Mol Case Stud. 2015;1(1):a000588.","journal-title":"Mol Case Stud"},{"key":"863_CR37","doi-asserted-by":"crossref","unstructured":"Mayer EA, Tillisch K. The brain-gut axis in abdominal pain syndromes. Ann Rev Med. 2011;62","DOI":"10.1146\/annurev-med-012309-103958"},{"issue":"3","key":"863_CR38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1365-2982.2010.01664.x","volume":"23","author":"JF Cryan","year":"2011","unstructured":"Cryan JF, O\u2019Mahony SM. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil. 2011;23(3):187\u201392.","journal-title":"Neurogastroenterol Motil"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-017-0863-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T01:50:53Z","timestamp":1719193853000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-017-0863-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["863"],"URL":"https:\/\/doi.org\/10.1186\/s12883-017-0863-9","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,11]]},"article-number":"88"}}