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The study protocol was approved by the local ethics committees of all participating study sites (London:Camden and Islington NRES Committee 14\/LO\/0612, Bordeaux: South West and Overseas Protection Committee III (South West and Overseas Protection Committee). 2014-A01501\u201346, Lisbon:Centro Hospitalar Lisboa Norte, DIRCLN-19SET2014\u2013275, Lund: EPN Regionala etikprovningsnamnden: Lund (EPN Regional Ethics Name: Lund). <i>JPND NC 559\u2013002,<\/i> Marburg: Ethik-Kommission bei der Landesarztekammer Hessen (Ethics Commission at the State Medical Association Hesse). MC 309\/2014, Munich: Ethikkommission bei der LMU Munchen (Ethics committee at the LMU Munchen). 193\u201314, Nijmegen: Radboud universitair medisch centrum, Concernstaf Kwaliteit en Veiligheid, Commissie Mensgebonden Onderzoek Regio Arnhem-Nijmegen (Radboud university medical center,Group staff Quality and Safety Human Research Committee, Arnhem-Nijmegen region). DJ\/CMO300).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Participants (patients and their caregivers) are included in the study after giving their written informed consent. In case the patient lacks capacity to give consent to the study due to severe cognitive impairment, the decision on study participation is made by a legal guardian or consultee, depending on the ethical and legal requirements at each site. All participants (patients and caregivers) can withdraw from the study at any point in time without any negative implications.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors have read the final manuscript and consented publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"185"}}