{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:09:10Z","timestamp":1791925750404,"version":"4.3.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Delayed cerebral ischemia is one of the leading causes of death and disability in patients with subarachnoid hemorrhage (SAH). Transluminal balloon angioplasty (TBA) is a therapeutic option for vasospasms affecting proximal intracranial arteries.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Aim of this study was to report our experience using the Scepter C balloon catheter in the treatment of cerebral vasospasms due to SAH and evaluate the postprocedural result with the iFlow tool. We reviewed cases of patients treated at our hospital from 2014 to 2018. Patients were screened with transcranial doppler sonography (TCD) and multimodal computed tomography. In case of significant vasospasms, patients were transferred to the angiography suite and treated. We used the iFlow tool to quantify and evaluate the angiographic results by measuring and comparing peak density values on angiograms before and after the mechanical dilation.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The use of the Scepter C balloon catheter was feasible in all cases. Vasospasms of the anterior cerebral artery were treated in ten cases. We didn\u2019t observe complications or vasospasm recurrences of the treated arteries. The temporal difference between distal vessels and the proximal reference vessel was significantly reduced from a mean of 53%, prior to dilatation, to 26% after the treatment. The difference between pre-dilatation and post-dilatation values was statistically significant for the anterior circulation at the proximal as well as at the distal vessels.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>We successfully treated endovascularly patients suffering from cerebral vasospasms refractory to medical treatment using the Scepter C balloon catheter. We didn\u2019t observe any complications. The therapeutic effect could be easily and reliably assessed with the iFlow tool.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12883-020-01792-3","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T09:03:40Z","timestamp":1593421420000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Angioplasty with the scepter C dual lumen balloon catheter and postprocedural result evaluation in patients with subarachnoid hemorrhage related vasospasms"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2561-9603","authenticated-orcid":false,"given":"Ioannis","family":"Tsogkas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Malinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Schregel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Mielke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Behme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Knauth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios-Nikos","family":"Psychogios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"issue":"1","key":"1792_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1017\/cjn.2015.288","volume":"43","author":"JM Findlay","year":"2016","unstructured":"Findlay JM, Nisar J, Darsaut T. Cerebral vasospasm: a review. Can J Neurol Sci. 2016;43(1):15\u201332.","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"1792_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0967-5868(94)90005-1","volume":"1","author":"NW Dorsch","year":"1994","unstructured":"Dorsch NW, King MT. A review of cerebral vasospasm in aneurysmal subarachnoid haemorrhage part I: incidence and effects. J Clin Neurosci. 1994;1(1):19\u201326.","journal-title":"J Clin Neurosci"},{"issue":"6","key":"1792_CR3","doi-asserted-by":"publisher","first-page":"830","DOI":"10.3171\/jns.1997.87.6.0830","volume":"87","author":"Y Murayama","year":"1997","unstructured":"Murayama Y, Malisch T, Guglielmi G, Mawad ME, Vinuela F, Duckwiler GR, et al. Incidence of cerebral vasospasm after endovascular treatment of acutely ruptured aneurysms: report on 69 cases. J Neurosurg. 1997;87(6):830\u20135.","journal-title":"J Neurosurg"},{"issue":"7","key":"1792_CR4","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1161\/01.STR.30.7.1402","volume":"30","author":"C Charpentier","year":"1999","unstructured":"Charpentier C, Audibert G, Guillemin F, Civit T, Ducrocq X, Bracard S, et al. Multivariate analysis of predictors of cerebral vasospasm occurrence after aneurysmal subarachnoid hemorrhage. Stroke. 1999;30(7):1402\u20138.","journal-title":"Stroke"},{"issue":"11","key":"1792_CR5","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJM198303173081103","volume":"308","author":"GS Allen","year":"1983","unstructured":"Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Chou SN, et al. Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage. N Engl J Med. 1983;308(11):619\u201324.","journal-title":"N Engl J Med"},{"issue":"3","key":"1792_CR6","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3171\/jns.1996.84.3.0405","volume":"84","author":"FG Barker 2nd","year":"1996","unstructured":"Barker FG 2nd, Ogilvy CS. Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a metaanalysis. J Neurosurg. 1996;84(3):405\u201314.","journal-title":"J Neurosurg"},{"issue":"3","key":"1792_CR7","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1227\/00006123-198803000-00006","volume":"22","author":"E Mee","year":"1988","unstructured":"Mee E, Dorrance D, Lowe D, Neil-Dwyer G. Controlled study of nimodipine in aneurysm patients treated early after subarachnoid hemorrhage. Neurosurgery. 1988;22(3):484\u201391.","journal-title":"Neurosurgery"},{"issue":"5","key":"1792_CR8","doi-asserted-by":"publisher","first-page":"683","DOI":"10.3171\/jns.1988.69.5.0683","volume":"69","author":"J Ohman","year":"1988","unstructured":"Ohman J, Heiskanen O. Effect of nimodipine on the outcome of patients after aneurysmal subarachnoid hemorrhage and surgery. J Neurosurg. 1988;69(5):683\u20136.","journal-title":"J Neurosurg"},{"issue":"4","key":"1792_CR9","doi-asserted-by":"publisher","first-page":"505","DOI":"10.3171\/jns.1988.68.4.0505","volume":"68","author":"KC Petruk","year":"1988","unstructured":"Petruk KC, West M, Mohr G, Weir BK, Benoit BG, Gentili F, et al. Nimodipine treatment in poor-grade aneurysm patients. Results of a multicenter double-blind placebo-controlled trial. J Neurosurg. 1988;68(4):505\u201317.","journal-title":"J Neurosurg"},{"issue":"3\u20134","key":"1792_CR10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/BF01456369","volume":"82","author":"J Philippon","year":"1986","unstructured":"Philippon J, Grob R, Dagreou F, Guggiari M, Rivierez M, Viars P. Prevention of vasospasm in subarachnoid haemorrhage. A controlled study with nimodipine. Acta Neurochir. 1986;82(3\u20134):110\u20134.","journal-title":"Acta Neurochir"},{"issue":"6674","key":"1792_CR11","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1136\/bmj.298.6674.636","volume":"298","author":"JD Pickard","year":"1989","unstructured":"Pickard JD, Murray GD, Illingworth R, Shaw MD, Teasdale GM, Foy PM, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ. 1989;298(6674):636\u201342.","journal-title":"BMJ"},{"issue":"6","key":"1792_CR12","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.wneu.2015.01.036","volume":"83","author":"M Hollingworth","year":"2015","unstructured":"Hollingworth M, Chen PR, Goddard AJ, Coulthard A, Soderman M, Bulsara KR. Results of an international survey on the investigation and endovascular Management of Cerebral Vasospasm and Delayed Cerebral Ischemia. World Neurosurg. 2015;83(6):1120\u20136 e1121.","journal-title":"World Neurosurg"},{"issue":"3","key":"1792_CR13","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S1042-3680(18)30511-4","volume":"5","author":"JM Eskridge","year":"1994","unstructured":"Eskridge JM, Newell DW, Winn HR. Endovascular treatment of vasospasm. Neurosurg Clin N Am. 1994;5(3):437\u201347.","journal-title":"Neurosurg Clin N Am"},{"issue":"5","key":"1792_CR14","first-page":"391","volume":"37","author":"TJ Coyne","year":"1994","unstructured":"Coyne TJ, Montanera WJ, Macdonald RL, Wallace MC. Percutaneous transluminal angioplasty for cerebral vasospasm after subarachnoid hemorrhage. Can J Surg. 1994;37(5):391\u20136.","journal-title":"Can J Surg"},{"issue":"5","key":"1792_CR15","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1097\/00006123-199805000-00013","volume":"42","author":"GK Bejjani","year":"1998","unstructured":"Bejjani GK, WOF B, Olan WJ, Sekhar LN. The efficacy and safety of angioplasty for cerebral vasospasm after subarachnoid hemorrhage. Neurosurgery. 1998;42(5):979\u201386 discussion 986-977.","journal-title":"Neurosurgery"},{"issue":"1","key":"1792_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/BF00416470","volume":"18","author":"Y Fujii","year":"1995","unstructured":"Fujii Y, Takahashi A, Yoshimoto T. Effect of balloon angioplasty on high grade symptomatic vasospasm after subarachnoid hemorrhage. Neurosurg Rev. 1995;18(1):7\u201313.","journal-title":"Neurosurg Rev"},{"issue":"2","key":"1792_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1097\/00006123-200002000-00037","volume":"46","author":"GP Teitelbaum","year":"2000","unstructured":"Teitelbaum GP, Larsen DW, Zelman V, Lysachev AG, Likhterman LB. A tribute to Dr. Fedor a. Serbinenko, founder of endovascular neurosurgery. Neurosurgery. 2000;46(2):462\u20139 discussion 469-470.","journal-title":"Neurosurgery"},{"issue":"6","key":"1792_CR18","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3171\/JNS-07\/12\/1101","volume":"107","author":"NR Gonzalez","year":"2007","unstructured":"Gonzalez NR, Boscardin WJ, Glenn T, Vinuela F, Martin NA. Vasospasm probability index: a combination of transcranial doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2007;107(6):1101\u201312.","journal-title":"J Neurosurg"},{"issue":"6","key":"1792_CR19","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s00270-016-1296-3","volume":"39","author":"K Yamamoto","year":"2016","unstructured":"Yamamoto K, Nakai G, Azuma H, Narumi Y. Novel software-assisted hemodynamic evaluation of pelvic flow during Chemoperfusion of pelvic arteries for bladder cancer: double- versus single-balloon technique. Cardiovasc Intervent Radiol. 2016;39(6):824\u201330.","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"1792_CR20","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3171\/jns.1990.73.1.0018","volume":"73","author":"NF Kassell","year":"1990","unstructured":"Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL. The international cooperative study on the timing of aneurysm surgery. Part 1: overall management results. J Neurosurg. 1990;73(1):18\u201336.","journal-title":"J Neurosurg"},{"issue":"7","key":"1792_CR21","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1161\/01.STR.25.7.1342","volume":"25","author":"JP Broderick","year":"1994","unstructured":"Broderick JP, Brott TG, Duldner JE, Tomsick T, Leach A. Initial and recurrent bleeding are the major causes of death following subarachnoid hemorrhage. Stroke. 1994;25(7):1342\u20137.","journal-title":"Stroke"},{"issue":"9","key":"1792_CR22","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1161\/01.STR.26.9.1553","volume":"26","author":"F Proust","year":"1995","unstructured":"Proust F, Hannequin D, Langlois O, Freger P, Creissard P. Causes of morbidity and mortality after ruptured aneurysm surgery in a series of 230 patients. The importance of control angiography. Stroke. 1995;26(9):1553\u20137.","journal-title":"Stroke"},{"issue":"19","key":"1792_CR23","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1212\/WNL.0b013e3181dd42b3","volume":"74","author":"CE Lovelock","year":"2010","unstructured":"Lovelock CE, Rinkel GJ, Rothwell PM. Time trends in outcome of subarachnoid hemorrhage: population-based study and systematic review. Neurology. 2010;74(19):1494\u2013501.","journal-title":"Neurology"},{"issue":"5 Suppl 3","key":"1792_CR24","first-page":"S139","volume":"59","author":"M Zwienenberg-Lee","year":"2006","unstructured":"Zwienenberg-Lee M, Hartman J, Rudisill N, Muizelaar JP. Endovascular management of cerebral vasospasm. Neurosurgery. 2006;59(5 Suppl 3):S139\u201347 discussion S133\u2013113.","journal-title":"Neurosurgery"},{"issue":"3","key":"1792_CR25","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1227\/01.NEU.0000311351.32904.8B","volume":"62","author":"L Jestaedt","year":"2008","unstructured":"Jestaedt L, Pham M, Bartsch AJ, Kunze E, Roosen K, Solymosi L, et al. The impact of balloon angioplasty on the evolution of vasospasm-related infarction after aneurysmal subarachnoid hemorrhage. Neurosurgery. 2008;62(3):610\u20137 discussion 610-617.","journal-title":"Neurosurgery"},{"issue":"3","key":"1792_CR26","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.nec.2005.04.004","volume":"16","author":"BL Hoh","year":"2005","unstructured":"Hoh BL, Ogilvy CS. Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine. Neurosurg Clin N Am. 2005;16(3):501\u201316 vi.","journal-title":"Neurosurg Clin N Am"},{"issue":"1","key":"1792_CR27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1227\/NEU.0b013e31821424f9","volume":"69","author":"A Santillan","year":"2011","unstructured":"Santillan A, Knopman J, Zink W, Patsalides A, Gobin YP. Transluminal balloon angioplasty for symptomatic distal vasospasm refractory to medical therapy in patients with aneurysmal subarachnoid hemorrhage. Neurosurgery. 2011;69(1):95\u2013101 discussion 102.","journal-title":"Neurosurgery"},{"issue":"3","key":"1792_CR28","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s12028-013-9825-2","volume":"20","author":"WG Tekle","year":"2014","unstructured":"Tekle WG, Chaudry SA, Hassan AE, Qaiser H, Grigoryan M, Rodriguez GJ, et al. High risk of new episode of symptomatic vasospasm in unaffected arteries in subarachnoid hemorrhage patients receiving targeted endovascular treatment for symptomatic focal vasospasm. Neurocrit Care. 2014;20(3):399\u2013405.","journal-title":"Neurocrit Care"},{"issue":"2","key":"1792_CR29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1136\/neurintsurg-2012-010572","volume":"6","author":"S John","year":"2014","unstructured":"John S, Spiotta AM, Turner RM, Chaudry MI, Turk AS, Hui F. Initial experience with the coaxial dual-lumen scepter C balloon catheter for endovascular management of cerebral vasospasm from subarachnoid hemorrhage. J Neurointerventional Surg. 2014;6(2):125\u20138.","journal-title":"J Neurointerventional Surg"},{"issue":"6","key":"1792_CR30","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","volume":"43","author":"ES Connolly Jr","year":"2012","unstructured":"Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/american Stroke Association. Stroke. 2012;43(6):1711\u201337.","journal-title":"Stroke"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-020-01792-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12883-020-01792-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12883-020-01792-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T23:36:34Z","timestamp":1624923394000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/s12883-020-01792-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1792"],"URL":"https:\/\/doi.org\/10.1186\/s12883-020-01792-3","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"15 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee from University medical center Goettingen approved that all procedures performed in this study were in accordance with the ethical standards of our institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The data were prospectively collected for a previous research project, which was approved by the local ethics committee (Number 22\/11\/12). Informed consent was waived, given the retrospective nature of the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The Department of Neuroradiology has a research agreement with Siemens Medical Solutions, Forchheim, Germany. DB has received speaker\u2019s honoraria from Stryker, Penumbra and Acandis. VR has received fees from B-Braun, Aesculap. MNP has received fees as consultant or lecturer from Siemens, Penumbra and Stryker.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"260"}}